GENFIT

Many research topics in the fields of condensed matter and the life sciences are based on small-angle X-ray and neutron scattering techniques. With the current rapid progress in source brilliance and detector technology, high data fluxes of ever-increasing quality are produced. In order to exploit such a huge quantity of data and richness of information, wider and more sophisticated approaches to data analysis are needed. Presented here is GENFIT, a new software tool able to fit small-angle scattering data of randomly oriented macromolecular or nanosized systems according to a wide list of models, including form and structure factors. Batches of curves can be analysed simultaneously in terms of common fitting parameters or by expressing the model parameters via physical or phenomenological link functions. The models can also be combined, enabling the user to describe complex heterogeneous systems

GENFIT: software for the analysis of small-angle X-ray and neutron scattering data of macro­molecules in solution

Many research topics in the fields of condensed matter and the life sciences are based on small-angle X-ray and neutron scattering techniques. With the current rapid progress in source brilliance and detector technology, high data fluxes of ever-increasing quality are produced. In order to exploit such a huge quantity of data and richness of information, wider and more sophisticated approaches to data analysis are needed. Presented here is GENFIT, a new software tool able to fit small-angle scattering data of randomly oriented macromolecular or nanosized systems according to a wide list of models, including form and structure factors. Batches of curves can be analysed simultaneously in terms of common fitting parameters or by expressing the model parameters via physical or phenomenological link functions. The models can also be combined, enabling the user to describe complex heterogeneous systems

Online data analysis at the ESRF bioSAXS beamline, BM29

International audienc

CM01: a facility for cryo-electron microscopy at the European Synchrotron

International audienceRecent improvements in direct electron detectors, microscope technology and software provided the stimulus for a `quantum leap' in the application of cryo-electron microscopy in structural biology, and many national and international centres have since been created in order to exploit this. Here, a new facility for cryo-electron microscopy focused on single-particle reconstruction of biological macromolecules that has been commissioned at the European Synchrotron Radiation Facility (ESRF) is presented. The facility is operated by a consortium of institutes co-located on the European Photon and Neutron Campus and is managed in a similar fashion to a synchrotron X-ray beamline. It has been open to the ESRF structural biology user community since November 2017 and will remain open during the 2019 ESRF-EBS shutdown

Enabling Open Science for Photon and Neutron Sources

International audiencePhoton and Neutron sources are producing more and more petabytes of scientific data each year. At the same time scientific publishing is evolving to make scientific data part of publications. The Photon and Neutron Open Science Cloud (PaNOSC*) project is a EU financed project to provide scientific data management for enabling Open Science. Data will be managed according to the FAIR principles. This means data will be curated and made available under an Open Data policy, findable, interoperable and reusable. This paper will describe how the European photon and neutron sources on the ESFRI** roadmap envision PaNOSC as part of the European Open Science Cloud***. The paper will address the issues of data policy, metadata, data curation, long term archiving and data sharing in the context of the latest developments in these areas