Percent body fat distributions for the 36 RNAi knock down Drosophila gene crosses, testing significantly different from corresponding Wild Type control, by Dunnett’s multiple comparisons test.

<p>Percent body fat distributions for the 36 RNAi knock down Drosophila gene crosses, testing significantly different from corresponding Wild Type control, by Dunnett’s multiple comparisons test.</p

Percent body fat distributions for the 36 RNAi knock down Drosophila gene crosses, testing significantly different from corresponding Wild Type control, by Dunnett’s multiple comparisons test.

<p>Percent body fat distributions for the 36 RNAi knock down Drosophila gene crosses, testing significantly different from corresponding Wild Type control, by Dunnett’s multiple comparisons test.</p

Results of the functional drosophila screen for all genes nearby (± 250 kb) the 78 BMI-associated GWAS loci from speliotes et al. 2010[30] and locke et al. 2015[31].

<p>Results of the functional drosophila screen for all genes nearby (± 250 kb) the 78 BMI-associated GWAS loci from speliotes et al. 2010[<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007222#pgen.1007222.ref030" target="_blank">30</a>] and locke et al. 2015[<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007222#pgen.1007222.ref031" target="_blank">31</a>].</p

Summary of Drosophila functional scan for the 61 BMI GWAS loci that could be tested in the fly.

<p>Number of GWAS BMI loci for which nearby genes were validated in RNAi KDs in Drosophila. <b>(a)</b> Distribution of Number of Significant Fly KD Genes per BMI Locus Region. Significance determined by Dunnett’s Multiple Comparisons Test. <b>(b)</b> Number of Significant Fly KD Genes per BMI Locus by Proximity to SNP. Significance determined by Dunnett’s Multiple Comparisons Test. CNBT = Could Not Be Tested in Fly (either No Fly Ortholog or KD lethal).</p

Experimental design of the Drosophila BMI loci functional screen.

<p>WT = Corresponding RNAi Wild Type (as detailed in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007222#pgen.1007222.g003" target="_blank">Fig 3</a>).</p

Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).

<p>Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).</p

Novel SNVs/Genes associated with BP traits in Multi-ancestry meta-analysis in combined Stage 1 and Stage 2.

<p>Novel SNVs/Genes associated with BP traits in Multi-ancestry meta-analysis in combined Stage 1 and Stage 2.</p

Novel SNVs/Genes associated with BP traits in European ancestry.

<p>Novel SNVs/Genes associated with BP traits in European ancestry.</p

Novel SNVs/Genes associated with BP traits from correlated meta-analysis in European ancestry in Stage 1.

<p>Novel SNVs/Genes associated with BP traits from correlated meta-analysis in European ancestry in Stage 1.</p

Potential novel SNVs/Genes associated with BP traits in African ancestry.

<p>Potential novel SNVs/Genes associated with BP traits in African ancestry.</p