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Comparison of herbarium label data and published medicinal use: herbaria as an underutilized source of ethnobotanical information
The use of herbarium specimens as vouchers to support ethnobotanical surveys is well established. However,
herbaria may be underutilized resources for ethnobotanical research that depends on the analysis of large datasets compiled across multiple sites. Here, we compare two medicinal use datasets, one sourced from
published papers and the other from online herbaria to determine whether herbarium and published data
are comparable and to what extent herbarium specimens add new data and fill gaps in our knowledge of
geographical extent of plant use. Using Brazilian legumes as a case study, we compiled 1400 use reports from
105 publications and 15 Brazilian herbaria. Of the 319 species in 107 genera with cited medicinal uses, 165
(51%) were recorded only in the literature and 55 (17%) only on herbarium labels. Mode of application,
plant part used, or therapeutic use was less often documented by herbarium specimen labels (17% with
information) than publications (70%). However, medicinal use of 21 of the 128 species known from only
one report in the literature was substantiated from independently collected herbarium specimens, and 58
new therapeutic applications, 25 new plant parts, and 16 new modes of application were added for species
known from the literature. Thus, when literature reports are few or information-poor, herbarium data can
both validate and augment these reports. Herbarium data can also provide insights into the history and
geographical extent of use that are not captured in publications
Neuronal circuitry for pain processing in the dorsal horn
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region
Mortalidade, anos potenciais de vida perdidos e incidência de acidentes de trabalho na Bahia, Brasil
Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats
Abstract The purpose of this study was to perform a microcomputed tomographic evaluation of the radioprotective effect of resveratrol on the volume of mandibular incisors of irradiated rats. A second aim was to make a quantitative assessment of the effect of x-ray exposure on these dental tissues. Twenty adult male rats were divided into four groups: control, irradiated control, resveratrol, and irradiated resveratrol. The resveratrol groups received 100 mg/kg of resveratrol, whereas the irradiated groups were exposed to 15 Gy of irradiation. The animals were sacrificed 30 days after the irradiation procedure, and their mandibles were removed and scanned in a microcomputed tomography unit. The images were loaded into Mimics software to allow segmentation of the mandibular incisor and assessment of its volume. The results were compared by One-way ANOVA and Tukey’s post hoc test, considering a 5% significance level. The irradiated groups showed significantly diminished volumes of the evaluated teeth, as compared with the control group (p < 0.05). The resveratrol group presented higher values than those of the irradiated groups, and volumes similar to those of the control group. High radiation doses significantly affected tooth formation, resulting in alterations in the dental structure, and thus lower volumes. Moreover, resveratrol showed no effective radioprotective impact on dental tissues. Future studies are needed to evaluate different concentrations of this substance, in an endeavor to verify its potential as a radioprotector for these dental tissues
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