Dibenzo[a,g]quinolizin-8-ones: synthesis, estrogen receptor affinities, and cytostatic activity

A number of acetoxy-substituted dibenzo[a,g]quinolizin-8-ones were synthesized by the reaction of 1-oxoisoquinolines with substituted homophthalic acid anhydride. All of the derivatives with acetoxy groups in positions 3 and 10 bind to the estrogen receptor. Relative binding affinities (RBA) ranged from 1.8 to 5.6 (estradiol: RBA = 100) when the substituent at C-6 was a short alkyl group. Introduction of additional oxygen functions in the 2- and/or 11-position decreased binding affinities. Analyses of the enantiomers of 6-methyl (6b) and 6-ethyl (6c) derivatives revealed that the receptor binding is mainly due to one optical isomer (e.g. (-)-6b, 9.9; (+)-6b, 0.6). In hormone-sensitive human MCF-7 breast cancer cells, compounds with one acetoxy group in each aromatic ring strongly inhibited cellular growth. Despite marked differences in receptor affinity, the enantiomers displayed similar activities in this cell culture. In hormone-independent MDA-MB 231 mammary tumor cells, only a weak cytostatic effect was recorded at 10-5 M. In the immature mouse uterine weight test, minimal estrogenic activity was observed. At higher doses, a significant anti-estrogenic effect became evident. It is assumed that the estrogen antagonism is responsible for the specific cytostatic effect in MCF-7 breast cancer cells

Quantum Evolution of Inhomogeneities in Curved Space

We obtain the renormalized equations of motion for matter and semi-classical gravity in an inhomogeneous space-time. We use the functional Schrodinger picture and a simple Gaussian approximation to analyze the time evolution of the $\lambda\phi^4$ model, and we establish the renormalizability of this non-perturbative approximation. We also show that the energy-momentum tensor in this approximation is finite once we consider the usual mass and coupling constant renormalizations, without the need of further geometrical counter-terms.Comment: 22 page

Black Holes and Large Order Quantum Geometry

We study five-dimensional black holes obtained by compactifying M theory on Calabi-Yau threefolds. Recent progress in solving topological string theory on compact, one-parameter models allows us to test numerically various conjectures about these black holes. We give convincing evidence that a microscopic description based on Gopakumar-Vafa invariants accounts correctly for their macroscopic entropy, and we check that highly nontrivial cancellations -which seem necessary to resolve the so-called entropy enigma in the OSV conjecture- do in fact occur. We also study analytically small 5d black holes obtained by wrapping M2 branes in the fiber of K3 fibrations. By using heterotic/type II duality we obtain exact formulae for the microscopic degeneracies in various geometries, and we compute their asymptotic expansion for large charges.Comment: 42 pages, 20 eps figures, small correction

Stationary Points of Scalar Fields Coupled to Gravity

We investigate the dynamics of gravity coupled to a scalar field using a non-canonical form of the kinetic term. It is shown that its singular point represents an attractor for classical solutions and the stationary value of the field may occur distant from the minimum of the potential. In this paper properties of universes with such stationary states are considered. We reveal that such state can be responsible for modern dark energy density.Comment: H. Kroger, invited talk, FFP6, Udine (2004), revised version with corrected author lis

Characterization of nanometer-sized, mechanically exfoliated graphene on the H-passivated Si(100) surface using scanning tunnelling microscopy

We have developed a method for depositing graphene monolayers and bilayers with minimum lateral dimensions of 2-10 nm by the mechanical exfoliation of graphite onto the Si(100)-2x1:H surface. Room temperature, ultra-high vacuum (UHV) tunnelling spectroscopy measurements of nanometer-sized single-layer graphene reveal a size dependent energy gap ranging from 0.1-1 eV. Furthermore, the number of graphene layers can be directly determined from scanning tunnelling microscopy (STM) topographic contours. This atomistic study provides an experimental basis for probing the electronic structure of nanometer-sized graphene which can assist the development of graphene-based nanoelectronics.Comment: Accepted for publication in Nanotechnolog

Antireflective nanotextures for monolithic perovskite silicon tandem solar cells

Recently, we studied the effect of hexagonal sinusoidal textures on the reflective properties of perovskite silicon tandem solar cells using the finite element method FEM . We saw that such nanotextures, applied to the perovskite top cell, can strongly increase the current density utilization from 91 for the optimized planar reference to 98 for the best nanotextured device period 500 nm and peak to valley height 500 nm , where 100 refers to the Tiedje Yablonovitch limit. [D. Chen et al., J. Photonics Energy 8, 022601, 2018 , doi 10.1117 1.JPE.8.022601] In this manuscript we elaborate on some numerical details of that work we validate an assumption based on the Tiedje Yablonovitch limit, we present a convergence study for simulations with the finite element method, and we compare different configurations for sinusoidal nanotexture

Symmetries and Triplet Dispersion in a Modified Shastry-Sutherland Model for SrCu_2(BO_3)_2

We investigate the one-triplet dispersion in a modified Shastry-Sutherland Model for SrCu_2(BO_3)_2 by means of a series expansion about the limit of strong dimerization. Our perturbative method is based on a continuous unitary transformation that maps the original Hamiltonian to an effective, energy quanta conserving block diagonal Hamiltonian H_{eff}. The dispersion splits into two branches which are nearly degenerated. We analyse the symmetries of the model and show that space group operations are necessary to explain the degeneracy of the dispersion at k=0 and at the border of the magnetic Brillouin zone. Moreover, we investigate the behaviour of the dispersion for small |k| and compare our results to INS data.Comment: 9 pages, 8 figures accepted by J. Phys.: Condens. Matte

Decay Constants and Semileptonic Decays of Heavy Mesons in Relativistic Quark Model

We investigate the $B$ and $D$ mesons in the relativistic quark model by applying the variational method with the Gaussian wave function. We calculate the Fermi momentum parameter $p_{_F}$, and obtain $p_{_F} = 0.50 \sim 0.54$ GeV, which is almost independent of the input parameters, $\alpha_s$, $m_b$, $m_c$ and $m_{sp}$. We then calculate the ratio $f_B$/$f_D$, and obtain the result which is larger, by the factor of about 1.3, than $\sqrt{M_D / M_B}$ given by the naive nonrelativistic analogy. This result is in a good agreement with the recent Lattice calculations. We also calculate the ratio $(M_{B^*}-M_{B})$/$(M_{D^*}-M_{D})$. In these calculations the wave function at origin $\psi (0)$ is essential. We also determine $p_{_F}$ by comparing the theoretical prediction of the ACCMM model with the lepton energy spectrum of $B \rightarrow e \nu X$ from the recent ARGUS analysis, and find that $p_{_F}=0.27~\pm~^{0.22}_{0.27}$ GeV, when we use $m_c=1.5$ GeV. However, this experimentally determined value of $p_{_F}$ is strongly dependent on the value of input parameter $m_c$.Comment: 15 pages (Latex) (uses epsfig.sty, 1 figure appended as a uuencoded compressed ps-file