Pape satan aleppe

Ġabra ta’ poeżiji u proża li tinkludi: Qniepen idoqqu ta’ W. Gulia – Wara l-laqgħa ta’ Dun Abbondju mal-bravi ta’ Dun Pawl – Il-poeżija tiegħi ta’ Ġużè Chetcuti – Tfajjel sajjied ta’ Vincent Caruana – Huma kollox! ta’ Ġer. Azzopardi – Dun Mikiel Xerri ta’ Ġino Muscat-Azzopardi – Quddiem għalqa tal-bittieħ ta’ A. Buttigieg – Montecatini ta’ A. Cremona – Bluha ta’ mument ta’ Jos. Cassar Pullicino – Pape satan aleppe ta’ Albert M. Cassola.N/

Lil Rużar Briffa

Ġabra ta’ poeżiji u proża li tinkludi: Fil-mewt tat-tabib Rużar Briffa ta’ Ġużè Chetcuti – Fil-mewt ta’ Rużar Briffa ta’ P. Valentin Barbara – Lil Rużar ta’ qalbi ta’ Ġorġ Pisani – Poeżiji ta’ Rużar Briffa mhux ippubblikati – Vjolin Marid – Il-każin Malti – Frammenti – Il-ħmar – Lil Rużar Briffa, il-ġenna ta’ Albert M. Cassola – Kellimni fuq Rużar ta’ Ġużè Cardona – Lil F.S. Caruana ta’ R. Briffa – Lil Rużar Briffa ta’ F.S. Caruana.peer-reviewe

Can Archival Tissue Reveal Answers to Modern Research Questions?: Computer-Aided Histological Assessment of Neuroblastoma Tumours Collected over 60 Years

Despite neuroblastoma being the most common extracranial solid cancer in childhood, it is still a rare disease. Consequently, the unavailability of tissue for research limits the statistical power of studies. Pathology archives are possible sources of rare tissue, which, if proven to remain consistent over time, could prove useful to research of rare disease types. We applied immunohistochemistry to investigate whether long term storage caused any changes to antigens used diagnostically for neuroblastoma. We constructed and quantitatively assessed a tissue microarray containing neuroblastoma archival material dating between 1950 and 2007. A total of 119 neuroblastoma tissue cores were included spanning 6 decades. Fourteen antibodies were screened across the tissue microarray (TMA). These included seven positive neuroblastoma diagnosis markers (NB84, Chromogranin A, NSE, Ki-67, INI1, Neurofilament Protein, Synaptophysin), two anticipated to be negative (S100A, CD99), and five research antibodies (IL-7, IL-7R, JAK1, JAK3, STAT5). The staining of these antibodies was evaluated using Aperio ImageScope software along with novel pattern recognition and quantification algorithms. This analysis demonstrated that marker signal intensity did not decrease over time and that storage for 60 years had little effect on antigenicity. The construction and assessment of this neuroblastoma TMA has demonstrated the feasibility of using archival samples for research

Expression Profiling Reveals MSX1 and EphB2 Expression Correlates With the Invasion Capacity of Wilms Tumors

Background. Wilms tumor is the most common pediatric renal malignancy, but the parameters that are important to its invasion capacity are poorly understood. The aim of this study was to identify new proteins associated with the invasion capacity of Wilms tumor. Procedure. Gene expression profiles for 15 primary Wilms tumor samples were determined by Affymetrix Genechip (R) Human Genome Ul33A microarray analysis. The gene expression profiles for selected genes was further confirmed by quantitative RTPCR analysis. Immunohistochemical analysis was performed on 25 Wilms tumor cases to confirm expression for Bcl2A1, EphB2, MSX1, and RIN1. Results. Using microarray analysis 14 genes showed differential expression (P < 0.05) comparing stage 1 non-invasive Wilms tumor to stages 2-4 invasive Wilms tumor. The differential expression for Bcl2A1, EphB2, MSX1, and RIN1 was confirmed by quantitative RT-PCR. MSX1 protein was statistically significantly lower in stages 2-4 invasive Wilms tumor cases compared to stage 1 non-invasive cases (P = 0.013). EphB2 protein was higher in stages 2-4 Wilms tumor cases compared to stage 1 cases (P = 0.006). There was no statistically significant difference between stages 1 and 2-4 Wilms tumor for Bcl2A1 (P = 0.230) or RIN1 (P = 0.969) at the protein level. Conclusion. Our results indicate that MSX1 may be associated with the invasion capacity of Wilms tumors. RIN1 is a downstream effector of RAS and Bcl2A1 functions as an anti-apoptotic protein. EphB2 is an ephrin receptor and is up-regulated in invasive tumors but its role needs to be confirmed in further cases of Wilms tumors. Pediatr Blood Cancer 2011; 57: 950-957. (C) 2011 Wiley-Liss, Inc

Jekk lejn is-sema tħares

Ġabra ta’ poeżiji u proża li tinkludi: It-tberik tal-mejda ta’ l-ikel fil-pranzu f’ġieħ il-president tal-Għaqda fl-“Hotel Phoenicia” ta’ Ġ. M. Farrugia – Omm ħelwa tal-bnedmin ta’ Dun Frans Camilleri – Ġesù u l-Madliena ta’ Erin Serracino Inglott – Pape Satan Aleppe ta’ Albert M. Cassola – U hekk għal dejjem ta’ Ġużè Chetcuti – Jekk lejn is-sema tħares ta’ Nemo.N/

Ġirja

Ġabra ta’ poeżiji u proża li tinkludi: Għaddi malajr, Ġesù! ta’ Dun Frans Camilleri – Ilkoll għal hemm ta’ Lino Bonnici Farrugia – Ħolm ta’ John Sciberras – Ave Maria ta’ Ġużè Chetcuti – Rwiefen ta’ Ivo Muscat-Azzopardi – Fuq il-mewt ta’ Dr. F. W. Maempel, M. D., M. L. A. ta’ Vincent Ungaro – Pape satan aleppe... ta’ Albert M. Cassola – Ġirja ta’ Ġużi Abela.N/

miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

A drawback of electrical stimulation for muscle control is that large, fatigable motor units are preferentially recruited before smaller motor units by the lowest-intensity electrical cuff stimulation. This phenomenon limits therapeutic applications because it is precisely the opposite of the normal physiological (orderly) recruitment pattern; therefore, a mechanism to achieve orderly recruitment has been a long-sought goal in physiology, medicine and engineering. Here we demonstrate a technology for reliable orderly recruitment in vivo. We find that under optical control with microbial opsins, recruitment of motor units proceeds in the physiological recruitment sequence, as indicated by multiple independent measures of motor unit recruitment including conduction latency, contraction and relaxation times, stimulation threshold and fatigue. As a result, we observed enhanced performance and reduced fatigue in vivo. These findings point to an unanticipated new modality of neural control with broad implications for nervous system and neuromuscular physiology, disease research and therapeutic innovation