Patterns of sensory nerve conduction abnormalities in demyelinating and axonal peripheral nerve disorders

The pattern of an abnormal median-normal sural (AMNS) sensory response is associated with acute and chronic inflammatory demyelinating polyradiculoneuropathy (AIDP and CIDP) and considered unusual in other types of neuropathy, although specificity and sensitivity of this pattern have not been evaluated. We compared sensory responses (patterns and absolute values) in patients with AIDP, CIDP, diabetic polyneuropathy (DP), and motor neuron disease (MND). Using strict criteria, the AMNS pattern occurred more frequently in recent onset AIDP (39%) compared with CIDP (28%), DP (14%–23%), or MND (22%) patients. This pattern was found in 3% of control subjects. The extreme pattern of an absent median-present sural response occurred only in AIDP and CIDP patients and in no other groups. Abnormalities of both nerves were more common in long-standing polyneuropathies such as CIDP and DP compared with AIDP or MND. Median nerve amplitudes were reduced significantly in AIDP, CIDP, and DP patients compared with MND patients, whereas sural nerve amplitudes were significantly reduced only in DP and CIDP patients. These findings may reflect early distal nerve involvement particularly in AIDP patients which is highlighted by differences in median and sural nerve recording electrode placement. We conclude that, in the appropriate clinical setting, the AMNS pattern, an absent median-present sural response pattern, or a reduced median amplitude compared with the sural amplitude supports a diagnosis of a primary demyelinating polyneuropathy. © 1993 John Wiley & Sons, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50157/1/880160304_ftp.pd

Answer to letter of S. Bajada and W. Knezevic

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26284/1/0000369.pd

In memorium: Jasper Daube MD

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156241/2/mus26916_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156241/1/mus26916.pd

Cotton seedling diseases : answers to frequently asked questions (1994)

New March 25, 1994

The relationship between body mass index and the diagnosis of carpal tunnel syndrome

Increased weignt and, more recently, body mass index (BMI), have been suggested as risk factors for carpal tunnel syndrome (CTS). In an effort to determine the relative risk (RR) of obesity in the development of CTS, 949 patients who had an evaluation of the right upper extremity that included motor and sensory conduction studies of the median and ulnar nerves were reviewed. Of these patients, 261 were diagnosed with a median mononeuropathy at the wrist. Those individuals who were classified as obese (BMI > 29) were 2.5 times more likely than slender individuals (BMI < 20) to be diagnosed with CTS. Forty-three percent of obese women and 32% of obese men had the diagnosis of CTS compared to 21% of slender women and 0% of slender men. © 1994 John Wiley & Sons, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50161/1/880170610_ftp.pd

Electrodiagnostic tests are unlikely to change management in those with a known cause of typical distal symmetric polyneuropathy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138297/1/mus25713_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138297/2/mus25713.pd

Spectrum of patients with EMG features of polyradiculopathy without neuropathy

We reviewed the medical records of 233 patients having electrodiagnostic evidence of polyradiculopathy. Patients with polyneuropathy or incomplete diagnostic evaluation were excluded. A clinical diagnosis was secured in 92 of the 118 remaining patients. Patients were separated into three groups based upon the anatomic location of root involvement: extradural (55), intradural-extraaxial (23), and intraaxial (14). Collectively, patients with intradural-extraaxial disorders had earlier disease onset, shorter symptom duration, and a higher disability score compared with the intraaxial or extradural groups. Pain was an initial complaint in 50 of 55 patients with extradural lesions, 20 of 23 with intradural-extraaxial disease, but only in 4 of 14 with intraaxial involvement. CSF abnormalities and reduced compound muscle action potential amplitudes were more common in the intradural-extraaxial group. We conclude that the anatomic localization of root involvement in patients with polyradiculopathy can be suggested by a combination of clinical, laboratory, and electrodiagnostic features.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50147/1/880130112_ftp.pd

Effects of age, sex, and anthropometric factors on nerve conduction measures

Associations among measures of median, ulnar, and sural nerve conduction and age, skin temperature, sex, and anthropometric factors were evaluated in a population of 105 healthy, asymptomatic adults without occupational exposure to highly repetitive or forceful hand exertions. Height was negatively associated with sensory amplitude in all nerves tested ( P < 0.001), and positively associated with median and ulnar sensory distal latencies ( P < 0.01) and sural latency ( P < 0.001). Index finger circumference was negatively associated with median and ulnar sensory amplitudes ( P < 0.05). Sex, in isolation from highly correlated anthropometric factors such as height, was not found to be a significant predictor of median or ulnar nerve conduction measures. Equations using age, height, and finger circumference for prediction of normal values are presented. Failure to adjust normal nerve conduction values for these factors decreases the diagnostic specificity and sensitivity of the described measures, and may result in misclassification of individuals. © 1992 John Wiley & Sons, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50152/1/880151007_ftp.pd

Effects of d‐amphetamine on quantitative measures of motor performance

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117170/1/cpt1972132251.pd

Innovative Development of a Cross-Center Timeline Planning Tool

The Payload Operations Integration Center (POIC) at Marshall Space Flight Center (MSFC) is the United States focal point to support operations controllers and payload developers conducting payload science operations for the National Aeronautics and Space Administration (NASA) aboard the International Space Station (ISS). Some of the key functions are planning, coordination and scheduling of science activities. This effort occurs in coordination with other NASA centers, international partners, and payload developers. The ability to efficiently plan and re-plan in response to change is critical to the flight planning teams. Additionally, in Fall 2017, NASA will increase its ability to perform payload science operations aboard the ISS with a fourth crew member. In order to support this, there will be an increasing need to quickly plan and schedule more activities. In the past, it was cumbersome and time-consuming to consolidate copious amounts of planning and change request data from various sources. Planners would summarize information from the Johnson Space Center (JSC) Operations Planning Timeline Integration System (OPTIMIS) and manually integrate it with other data in order to produce a Timeline Planning Summary (TPS). This lengthy process of updating static documents while planning and re-planning was cumbersome, introduced human error, and was inflexible to last minute changes. There was a need for a dynamic, more efficient, less erroneous, and more concise way of building a report that could be readily updated as fast as payload science plans change