The Inconsistent Assessment of Quality of Life in Patients Treated for Head and Neck Cancer with Anti-EGFR Inhibitors: A Systematic Scoping Review

In patients receiving treatment for head and neck cancer (HNC), there is a correlation between quality of life (QoL) scores and treatment outcomes. Higher QoL scores have been associated with improved survival. Despite this, the assessment of QoL in clinical trials varies considerably. Three databases (Scopus, PubMed, and Cinahl) were queried for articles published in English between 2006 and 2022. Two reviewers (SRS and ANT) performed study screening, data extraction, and risk of bias assessment. The authors identified 21 articles that met the inclusion criteria. A total of 5961 patients were evaluated. QoL was reported as average scores for specific variables across five different surveys in 12 included articles. Supplemental QoL data were available in 10 included studies. Critical appraisal of studies indicated a high risk of bias due to the inclusion of trials. There is no standard method for reporting QoL data in clinical trials for HNC patients undergoing treatment with anti-EGFR inhibitors. Future clinical trials should standardize their method for assessing and reporting quality-of-life data to increase patient-centered care and refine treatment choices to optimize survival

Transoral Robotic Surgery and the Unknown Primary

Row of buildings, outside, park side facade; The Lyon Convention Centre (part of the district known as the Cité Internationale) was built on the bank of the Rhône river to enable Lyon to host major international conferences. The river lies on one side of the 15 hectare site, the Parc de la Tête d’Or on the other. It includes underground public parking of 1,200 spaces (total area parking is 3,350 spaces), an exhibition area of 8,400 m2, 26 meeting rooms, a residential hotel (104 units), a 4-star hotel, three auditoriums and a 4000-m2 public square. It can accommodate up to 19,000 people. The facades of the complex cover almost a kilometer. It is also a performance venue. The rest of the Cité Internationale includes offices, restaurants, a casino, cinema, and a museum of contemporary art. The scheme is composed of pairs of buildings, built in phases, on either side of a central pedestrian street, and creates new visual and physical links between the park and the river. Clad in terracotta, this was the first RPBW project to introduce an extra outer layer of glass facade, enclosing an air gap that acts as a heat exchanger. Source: Renzo Piano Building Workshop [firm website]; http://www.rpbw.com/ (accessed 7/8/2014