Middle Darriwilian conodont zones in the uppermost San Juan limestone and the lower member of the Las Aguaditas formation, central Precordillera of San Juan, Argentina

The geological province of Precordillera is located in western Argentina. It extends 450 km meridionally and 110 km from east to west (Fig. 1) (Furque and Cuerda, 1979). The Lower Paleozoic stratigraphy is characterized by a thick succession of Cambro-Ordovician limestones, which were deposited in platform environments and interdigitate with clastic slope deposits toward the west (Keller et al., 1993; Astini, 1995).Fil: Feltes, Nicolás Alexis. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Museo de Paleontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Albanesi, Guillermo Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Museo de Paleontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Bergström, S. M.. Ohio State University; Estados Unido

Pacto Territorial San Genaro, hacia la búsqueda de un desarrollo local sustentable

Pacto Territorial San Genaro, hacia la búsqueda de un desarrollo local sustentableFil: Albanesi, Roxana. Universidad Nacional de Rosario. Facultad de Ciencias Agrarias; Argentin

Bioestratigrafía de conodontes y correlación global del Darriwiliano medio-Sandbiano inferior (Ordovícico) Formación Las Aguaditas, precordillera de San Juan, Argentina

En la Formación Las Aguaditas, en su sección tipo en la precordillera Argentina, se registraron conodontes del Darriwiliano medio al Sandbiano bajo. Se recuperaron un total de 9.974 especímenes de 46 muestras carbonáticas; estos representan 68 especies pertenecientes a 38 géneros. Se llevó a cabo un estudio bioestratigráfico para verificar la edad del intervalo que incluye el contacto entra las formaciones San Juan y Las Aguaditas. La presencia de taxones guía indican una edad darriwiliana media para este intervalo. Las siguientes biozonas fueron determinadas en el área de estudio: Zona de Lenodusvariabilis, con las subzonas de Periodongladysae y Paroistodushorridus, correspondientes al esquema establecido para la precordillera; las zonas de L.v ariabilis, Yangtzeplacognathuscrassusy la deE oplacognathuspseudoplanuscon la subzonas de Microzarkodinahagetiana y M.ozarkodella, y la Zona de Pygodusanserinus, según el esquema Báltico; la Zona de Periodonmacrodentatus, con las subzonas de Histiodellasinuosa,H.holodentatayH. cf. holodentata, y la Zona de P.zgierzensis con la subzona de H.kristinae que se correlaciona con el esquema norteamericano. Se reconoció una discontinuidad estratigráfica entre los miembros inferior y medio de la Formación Las Aguaditas. Esta comprende las zonas de Eoplacognathussuecicus y Pygodus serra, y la subzona inferior de la Zona de Pygodusanserinus. La variación en la diversidad de conodontes en la sección de estudio se corresponde con patrones de somerización y profundización, que a su vez son congruentes con los cambios en la litología. Luego de analizar la composición taxonómica de las muestras se reconocieron, de manera cuantitativa, tres asociaciones de conodontes: a) Asociación diversa de conodontes, b) Asociación de baja diversidad de conodontes, y c) Asociación de conodontes en fase de recuperación. Se propone aplicar para la precordillera central el esquema de biozonación de América del Norte debido a la afinidad de los taxones guía documentada, brindando una correlación intercontinental más precisa para el Ordovícico Medio a nivel global.Middle Darriwilian to lower Sandbian conodonts were recorded from the Las Aguaditas Formation at its type section in the Argentine Precordillera. A total of 9,974 conodont specimens were recovered from 46 carbonate samples, which represent 68 species of 38 genera. A biostratigraphic study verified a middle Darriwilian age for the interval spanning the contact between the San Juan and the Las Aguaditas formations. The following zones are determined in the study section: the Lenodusvariabilis Zone, with the Periodongladysae and Paroistodushorridus subzones following the Precordilleran scheme; the L.variabilis, Yangtzeplacognathuscrassus, and the Eoplacognathuspseudoplanuszones with the Microzarkodinahagetiana and M.ozarkodella subzones, and the Pygodusanserinus Zone, according to the Scandinavian scheme; the Periodonmacrodentatus Zone, with the Histiodellasinuosa,H.holodentata and H.cf. holodentatasubzones, and the P.zgierzensis Zone with the H.kristinae Subzone that correlates the North American scheme. A stratigraphic gap was recognized between the lower and middle members of the Las Aguaditas Formation. It comprises the Eoplacognathussuecicus and Pygodus serra zones, and the lower subzone of the PygodusanserinusZone. The variation of conodont diversity through the study section conforms to shallowing and deepening patterns, which accompanies the changes of the provenance lithology. Three conodont assemblages were quantitatively recognized: a) Diverse conodont association, b) Low diversity conodont association and c) Recovery phase association. We propose to use the North American biozonal scheme of conodonts for the Central Precordillera because of the affinity of documented index taxa, which provides a more accurate intercontinental correlation for the global Middle Ordovician Series.Fil: Feltes, Nicolás Alexis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Albanesi, Guillermo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Bergström, S. M.. Ohio State University; Estados Unido

Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.

Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. This protein initially was identified as an interacting partner for the G protein-coupled receptor kinases, and its overexpression was found to affect signaling and internalization of the prototypical beta(2)-adrenergic receptor. Here, we report that GIT1 overexpression regulates internalization of numerous, but not all, G protein-coupled receptors. The specificity of the GIT1 effect is not related to the type of G protein to which a receptor couples, but rather to the endocytic route it uses. GIT1 only affects the function of G protein-coupled receptors that are internalized through the clathrin-coated pit pathway in a beta-arrestin- and dynamin-sensitive manner. Furthermore, the GIT1 effect is not limited to G protein-coupled receptors because overexpression of this protein also affects internalization of the epidermal growth factor receptor. However, constitutive agonist-independent internalization is not regulated by GIT1, because transferrin uptake is not affected by GIT1 overexpression. Thus, GIT1 is a protein involved in regulating the function of signaling receptors internalized through the clathrin pathway and can be used as a diagnostic tool for defining the endocytic pathway of a receptor

Allelic Variants of HLA-C Upstream Region, PSORS1C3, MICA, TNFA and Genes Involved in Epidermal Homeostasis and Barrier Function Influence the Clinical Response to Anti-IL-12/IL-23 Treatment of Patients with Psoriasis

Several biologic therapies have been developed to treat moderate-to-severe psoriasis, with patients exhibiting different clinical benefits, possibly due to the heterogeneity of pathogenic processes underlying their conditions. Ustekinumab targets the IL-12/IL-23-p40 subunit and inhibits type-1 and type-17 T-cell responses. Although ustekinumab is effective as both short- and long-term treatment, therapeutic response varies considerably among patients. Ustekinumab biosimilars will be commercialized in the very next future, likely broadening the use of this drug in the treatment of psoriasis patients. Our pharmacogenomic study evaluated the influence of 417 single-nucleotide polymorphisms (SNPs) in psoriasis-risk alleles on the clinical response to ustekinumab in a cohort of 152 patients affected by moderate-to-severe plaque-type psoriasis. Differences in SNP pattern characterizing HLA-Cw6(+) or HLA-Cw6(-) patients, showing high or low responses to ustekinumab, were also analysed. We identified twelve SNPs in HLA-C upstream region (rs12189871, rs4406273, rs9348862 and rs9368670), PSORS1C3 (rs1265181), MICA (rs2523497), LCE3A-B intergenic region (rs12030223, rs6701730), CDSN (rs1042127, rs4713436), CCHCR1 (rs2073719) and in TNFA (rs1800610) genes associated with excellent response to ustekinumab. We also found that HLA-Cw6(+) and HLA-Cw6(-) patients carried out distinct patterns of SNPs associated with different clinical responses. The assessment of HLA-C alleles, together with other genetic variants, could be helpful for defining patients who better benefit from anti-IL-12/IL-23 therapy