An unfolding signifier: London's Baltic Exchange in Tallinn

In the summer of 2007 an unusual cargo arrived at Muuga and Paldiski harbors outside Tallinn. It consisted of nearly 50 containers holding over 1,000 tons of building material ranging from marble columns, staircases and fireplaces, to sculpted allegorical figures, wooden paneling and old-fashioned telephone booths. They were once part of the Baltic Exchange in the City of London. Soon they will become facets of the landscape of Tallinn. The following article charts this remarkable story and deploys this fragmented monument to analyze three issues relating to the Estonian capital: the relocation of the ‘Bronze Soldier’, the demolition of the Sakala Culture Center, and Tallinn’s future role as European Cultural Capital in 2011

Connectedness and local connectedness of topological groups and extensions

summary:It is shown that both the free topological group $F(X)$ and the free Abelian topological group $A(X)$ on a connected locally connected space $X$ are locally connected. For the Graev's modification of the groups $F(X)$ and $A(X)$, the corresponding result is more symmetric: the groups $F\Gamma(X)$ and $A\Gamma(X)$ are connected and locally connected if $X$ is. However, the free (Abelian) totally bounded group $FTB(X)$ (resp., $ATB(X)$) is not locally connected no matter how ``good'' a space $X$ is. The above results imply that every non-trivial continuous homomorphism of $A(X)$ to the additive group of reals, with $X$ connected and locally connected, is open. We also prove that any dense in itself subspace of the Sorgenfrey line has a Urysohn connectification. If $D$ is a dense subset of $\{0,1\}^{\frak c}$ of power less than $\frak c$, then $D$ has a Urysohn connectification of the same cardinality as $D$. We also strengthen a result of [1] for second countable Tychonoff spaces without open compact subspaces proving that it is possible to find a compact metrizable connectification of such a space preserving its dimension if it is positive

When is |C(X x Y)| = |C(X)||C(Y)|?

Sufficient conditions on the Tychonoff spaces X and Y are found that imply that the equation in the title holds. Sufficient conditions on the Tychonoff space X are found that ensure that the equation holds for every Tychonoff space Y . A series of examples (some using rather sophisticated cardinal arithmetic) are given that witness that these results cannot be generalized much

“STUDY ELECTRONIC COMMERCE DALAM PERSPEKTIF KOMUNIKASI MENURUT FORMULA LASSWELL GUNA MEMPEROLEH INFORMASI KOMUNIKASI TOKO ON-LINE (WEBSTORE)”

Kehadiran internet sebagai akibat dari perkembangan teknologi dapat memecahkan kesulitan yang ada sehingga internet diharapkan dapat memberi peluang-peluang yang baru dalam berinovasi, efektif dan efisien. Banyak perusahaan korporat dan ukm di Indonesia berusaha menggunakan berbagai strategi pemasaran untuk mencapai quota penjualan mereka. Salah satunya menggunakan webstore (toko on-line), namun mereka kurang menyadari apa yang diinginkan oleh konsumen. Biasanya mereka terlalu idealis didalam menentukan strategi pemasaran mereka. Berdasarkan alasan tersebut dapat ditelusuri keinginan pengguna toko on-line sebagai problem solving dalam menemukan proses bisnis tersebut salah satunya dengan menggunakan perspektif komunikasi menurut formula Lasswell sehingga dapat diketahui kebutuhan atau tantangan kedepan. Hasil penelitian menghasilkan beberapa informasi komunikasi berupa beberapa faktor rekomendasi yang dapat ditetapkan proses bisnisnya. Melalui proses bisnis tersebut yang kemudian dapat juga ditetapkan solusi bisnis untuk strategi penjualan yang dapat dikontribusikan kepada calon perancang toko on-line. Kata Kunci: E-Commerce, Formula Lasswell, Proses Bisnis, Solusi Bisnis

The effect of sodium bicarbonate administration on the vasopressor effect of high-dose epinephrine during cardiopulmonary resuscitation in swine,

Sodium bicarbonate is administered during cardiopulmonary resuscitation (CPR) for the treatment of systemic acidemia. However, the effect of administering standard-dose sodium bicarbonate on the vasopressor effect of epinephrine is unknown. This study compared the effects of sodium bicarbonate or normal saline on the vasopressor effect of epinephrine in 18 pigs. After 10 minutes of unassisted ventricular fibrillation, CPR was started using a pneumatic chest compression device. Two minutes after the start of CPR, sodium bicarbonate (1 mEq/kg) or normal saline (1 mL/kg) was administered into the right ventricle followed 1 minute later by epinephrine (0.2 mg/kg). Defibrillation was attempted at 8 minutes of CPR (18 minutes of ventricular fibrillation). Results demonstrated no significant differences in aortic systolic, aortic diastolic, or coronary perfusion pressure (CPP) between the two groups (1 minute after epinephrine, CPP was 22.6 +/- 13.3 mm Hg versus 21.1 +/- 20.7 mm Hg for the sodium bicarbonate and normal saline groups, respectively). However, when the data were stratified according to pH 7.4, the peak change in CPP was 12.7 +/- 21 mm Hg when pH 7.4 (P = .33). Resuscitation was also similar between the two groups (two of nine for sodium bicarbonate and one of nine for normal saline). In conclusion, the standard recommended dose of sodium bicarbonate did not alter the vasopressor effect of epinephrine or resuscitation compared with normal saline in this closed chest model of ventricular fibrillation and CPR.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30609/1/0000246.pd

Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-β1 and IL-6

BACKGROUND: AIDS-related non-Hodgkin's lymphoma (AIDS-NHL) is the second most frequent cancer associated with AIDS, and is a frequent cause of death in HIV-infected individuals. Experimental analysis of AIDS-NHL has been facilitated by the availability of an excellent animal model, i.e., simian Acquired Immunodeficiency Syndrome (SAIDS) in the rhesus macaque consequent to infection with simian immunodeficiency virus. A recent study of SAIDS-NHL demonstrated a lymphoma-derived cell line to be sensitive to the growth inhibitory effects of the ubiquitous cytokine, transforming growth factor-beta (TGF-beta). The authors concluded that TGF-beta acts as a negative growth regulator of the lymphoma-derived cell line and, potentially, as an inhibitory factor in the regulatory network of AIDS-related lymphomagenesis. The present study was conducted to assess whether other SAIDS-NHL and AIDS-NHL cell lines are similarly sensitive to the growth inhibitory effects of TGF-beta, and to test the hypothesis that interleukin-6 (IL-6) may represent a counteracting positive influence in their growth regulation. METHODS: Growth stimulation or inhibition in response to cytokine treatment was quantified using trypan blue exclusion or colorimetric MTT assay. Intracellular flow cytometry was used to analyze the activation of signaling pathways and to examine the expression of anti-apoptotic proteins and distinguishing hallmarks of AIDS-NHL subclass. Apoptosis was quantified by flow cytometric analysis of cell populations with sub-G1 DNA content and by measuring activated caspase-3. RESULTS: Results confirmed the sensitivity of LCL8664, an immunoblastic SAIDS-NHL cell line, to TGF-beta1-mediated growth inhibition, and further demonstrated the partial rescue by simultaneous treatment with IL-6. IL-6 was shown to activate STAT3, even in the presence of TGF-beta1, and thereby to activate proliferative and anti-apoptotic pathways. By comparison, human AIDS-NHL cell lines differed in their responsiveness to TGF-beta1 and IL-6. Analysis of a recently derived AIDS-NHL cell line, UMCL01-101, indicated that it represents immunoblastic AIDS-DLCBL. Like LCL-8664, UMCL01-101 was sensitive to TGF-beta1-mediated inhibition, rescued partially by IL-6, and demonstrated rapid STAT3 activation following IL-6 treatment even in the presence of TGF-beta1. CONCLUSION: These studies indicate that the sensitivity of immunoblastic AIDS- or SAIDS-DLBCL to TGF-beta1-mediated growth inhibition may be overcome through the stimulation of proliferative and anti-apoptotic signals by IL-6, particularly through the rapid activation of STAT3

Impact of relative dose intensity (RDI) in CHOP combined with rituximab (R-CHOP) on survival in diffuse large B-cell lymphoma

<p>Abstract</p> <p>Background</p> <p>Recently, maintaining higher relative dose intensity (RDI) of chemotherapeutic drugs has become a widespread practice in an attempt to achieve better outcomes in the treatment of aggressive lymphoma. The addition of rituximab to chemotherapy regimens has significantly improved outcome in diffuse large B-cell lymphoma (DLBL). However, it is unknown if higher RDI in chemotherapy when combined with rituximab leads to a better outcome in aggressive B-cell lymphoma.</p> <p>Methods</p> <p>We retrospectively evaluated the impact of the RDI of initial chemotherapy (consisting of cyclophosphamide, doxorubicin, vincristine and prednisolone with rituximab (R-CHOP) on outcome in 100 newly diagnosed DLBL patients.</p> <p>Results</p> <p>A multivariate Cox regression model showed that RDI trended towards a significant association with mortality [hazard ratio per 0.1 of RDI = 0.8; 95% confidence interval 0.6–1.0; <it>P </it>= 0.08]. Additionally, on multivariate logistic analysis, advanced age was a significant factor for reduced RDI.</p> <p>Conclusion</p> <p>Our data suggest that in DLBL patients, mortality was affected by RDI of R-CHOP as the initial treatment, and the retention of a high RDI could therefore be crucial.</p