Detection and classification characteristics of arrays of carbon black/organic polymer composite chemiresistive vapor detectors for the nerve agent simulants Dimethylmethylphosphonate and Diisopropylmethylphosponate

Arrays of conducting polymer composite vapor detectors have been evaluated for performance in the presence of the nerve agent simulants dimethylmethylphosphonate (DMMP) and diisopropylmethylphosponate (DIMP). Limits of detection for DMMP on unoptimized carbon black-organic polymer composite vapor detectors in laboratory air were estimated to be 0.047-0.24 mg m^(-3). These values are lower than the EC50 value for the nerve agents sarin (methylphosphonofluoridic acid, (1-methylethyl) ester) and soman, which have been established as equals 0.8 mg m^(-3). Arrays of these vapor detectors were easily able to resolve signatures due to exposures to DMMP from those due to DIMP or due to a variety of other test analytes in a laboratory air background. In addition, DMMP at 27 mg m^(-3) could be detected and differentiated from the signatures of the other test analytes in the presence of backgrounds of potential interferents in the background ambient, including water, methanol, benzene, toluene, diesel fuel, lighter fluid, vinegar and tetrahydrofuran, even when these interferents were present in much higher concentrations than that of the DMMP or DIMP being detected

TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus

Funding: This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001220), the UK Medical Research Council (FC001220), and the Wellcome Trust (FC001200). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We are indebted to The Francis Crick Institute Flow Cytometry facility, and in particular Bhavik Patel, Graham Preece, Wayne Turnbull and Phil Hobson. We would also like to thank The Francis Crick Institute Procedural Service Section for production of GA lines and Biological Services, especially Trisha Norton, Keith Williams and Adebambo Adekoya for animal husbandry and technical support; to Riccardo Guidi for constructive discussions and technical assistance. We would like to thank Gitta Stockinger and AhR Immunity Laboratory for providing technical support and reagents throughout this study. We also thank Richard Rance and the Wellcome Trust Sanger Institute’s 454 pyrosequencing team for generating 16S rRNA gene data.Peer reviewedPublisher PD

Use of Carp Eggs as a Feed for Fingerling Largemouth Bass

Fingerling largemouth bass (Micropterus salmoides), 20 mm total length, readily accepted carp eggs and reached a length of 43 mm in 25 days at a water temperature of 27°C. Survival was 52%. Carp eggs were more acceptable than moist feed to largemouth bass fingerlings 43 to 50 mm long. An average of 49% of the fish that refused to accept moist feed during the first training period accepted carp eggs and later accepted moist feed. Training success was greatest at the highest water temperature considered

Detection and classification characteristics of arrays of carbon black/organic polymer composite chemiresistive vapor detectors for the nerve agent simulants Dimethylmethylphosphonate and Diisopropylmethylphosponate

Arrays of conducting polymer composite vapor detectors have been evaluated for performance in the presence of the nerve agent simulants dimethylmethylphosphonate (DMMP) and diisopropylmethylphosponate (DIMP). Limits of detection for DMMP on unoptimized carbon black-organic polymer composite vapor detectors in laboratory air were estimated to be 0.047-0.24 mg m^(-3). These values are lower than the EC50 value for the nerve agents sarin (methylphosphonofluoridic acid, (1-methylethyl) ester) and soman, which have been established as equals 0.8 mg m^(-3). Arrays of these vapor detectors were easily able to resolve signatures due to exposures to DMMP from those due to DIMP or due to a variety of other test analytes in a laboratory air background. In addition, DMMP at 27 mg m^(-3) could be detected and differentiated from the signatures of the other test analytes in the presence of backgrounds of potential interferents in the background ambient, including water, methanol, benzene, toluene, diesel fuel, lighter fluid, vinegar and tetrahydrofuran, even when these interferents were present in much higher concentrations than that of the DMMP or DIMP being detected

Sign reversal of the spin-orbit constant for the C³Πᵤ state of N₂

Ab initio calculations are performed at the multireference configuration-interaction level of theory on the diagonal spin-orbit functions for the lowest non-Rydberg states of ³Πᵤ symmetry in molecular nitrogen. Spin-orbit constants deduced from the ab initio results confirm the recent suggestion, based on new experimental results, that the C³Πᵤ state of N₂, long known to be regular in the region of its potential-energy curve minimum, becomes inverted at higher energies. By removing the effects of the crossing C′ ³Πᵤ state, it is shown that Av for the C state changes sign from positive to negative near v=8, corresponding to a change in principal molecular-orbital configuration from (1σg)²(1σu)²(2σg)²(2σu)(3σg)²(1πu)⁴(1πg) to (1σg)²(1σu)²(2σg)²(2σu)²(3σg)(1πu)³(1πg)² at an internuclear distance near 1.4 Å.This work was supported by the Australian Research Council Discovery Program under Grant Nos. DP0558962 and DP0773050