The Utility of Cancer-Related Cultural Constructs to Understand Colorectal Cancer Screening Among African Americans

Data suggest that colorectal cancer could be cut by approximately 60% if all people aged 50 years or older received regular screening. Studies have identified socio-cultural attitudes that might inform cancer education and screening promotion campaigns. This article applies item response theory (IRT) to a set of survey items selected to assess sociocultural attitudes in order to determine how current measures may affect what we know about how these attitudes affect colorectal cancer screening (CRCS). Design and Methods. A survey of colorectal cancer screening, screening attitudes and cultural beliefs was administered to 1021 African Americans - 683 women and 338 men, ages 50 to 75. Eligibility criteria for participation included being born in the United States, selfidentified African American male or female, age 50 to 75 years. The IRT analysis was performed on 655 individuals with complete data for the 43 observed variables. Results. Twenty-nine items comprise the Multi-construct African American Cultural Survey (MAACS) that addresses seven cultural constructs: mistrust/distrust, privacy, ethnic identity, collectivism, empowerment, and male gender roles. The items provide adequate information about the attitudes of the population across most levels of the constructs assessed. Among the sociocultural variables considered, empowerment (OR=1.078; 95% CI: 1.008, 1.151) had the strongest association with CRCS adherence and privacy showed promise. Conclusions. The MAACS provides a fixed length questionnaire to assess African American CRCS attitudes, two new constructs that might assist in CRCS promotion, and a suggested focus for identification of additional constructs of interest

Species Richness, Distribution, and Relative Abundance of Freshwater Mussels (Bivalvia: Unionidae) of the Buffalo National River, Arkansas

The Buffalo River in north-central Arkansas is approximately 246 km long and flows through the Boston Mountains and Springfield and Salem Plateaus to the White River near Buffalo City. The Buffalo River is America’s first National River with the National Park Service owning 11% of land in the watershed. The objectives of this project were to survey the entire perennially wet length of river, search for mussels of conservation concern, and document the freshwater mussel assemblages. During 2004 and 2005, 235 km of the river were qualitatively and quantitatively surveyed. We documented 64 mussel assemblages. Time constrained qualitatively sampled assemblages (n=41) resulted in a mean richness of 7.8 with a range of 2 to 12 species. Quantitatively sampled mussel assemblages (n=23) had a mean richness of 9.5, ranging from 4 to 16 species and a mean density of 6.9 individuals/m2 , ranging from 1.3 to 25.6 individuals/m2 . Detrended correspondence analysis revealed 4 distinct community types dominated by: 1) Ptychobranchus occidentalis (Conrad 1836), 2) Villosa iris (Lea 1829), 3) Cyclonaias tuberculata (Rafinesque 1820), and 4) Actinonaias ligamentina (Lamarck 1819) that represented approximate species gradients along the river’s length. Previous surveys collectively recorded a total of 26 species for the river, however; only 23 species were identified in this survey with no federally listed threatened or endangered species found. The Buffalo National River has a moderately diverse and abundant native freshwater mussel fauna. Seventy-eight percent of the current species are considered to be of conservation concern (S1-S3). Consequently, the Buffalo National River may prove to be an important refuge for a declining mussel resource

Prospects for photon blockade in four level systems in the N configuration with more than one atom

We show that for appropriate choices of parameters it is possible to achieve photon blockade in idealised one, two and three atom systems. We also include realistic parameter ranges for rubidium as the atomic species. Our results circumvent the doubts cast by recent discussion in the literature (Grangier et al Phys. Rev Lett. 81, 2833 (1998), Imamoglu et al Phys. Rev. Lett. 81, 2836 (1998)) on the possibility of photon blockade in multi-atom systems.Comment: 8 page, revtex, 7 figures, gif. Submitted to Journal of Optics B: Quantum and Semiclassical Optic

NEOTωIST: A relatively Inexpensive Kinetic Impactor Demonstration Mission Concept

Mission concept: NEOTωIST stands for Near-Earth Object Transfer of angular momentum (ω∙I) Spin Test, and is a concept for a kinetic impactor demonstration mission, which aims to change the spin rate of an asteroid by impacting it off-center (Drube et al. 2016, Engel et al. 2016). The change would be measured by means of lightcurve measurements with Earth-based telescopes. In contrast to most other kinetic impactor demonstration mission concepts, NEOTωIST does not require a reconnaissance spacecraft to rendezvous with the target asteroid for orbit change and impact-effect measurements, and is therefore a relatively inexpensive alternative. The NEOTωIST mission would determine the efficiency of momentum transfer (the β-factor) during an impact, and help mature the technology required for a kinetic impactor mission, both of which are important precursor measures for a future space mission to deflect an asteroid by collisional means in an emergency impact hazard situation

Digital Signal Processing

Contains research objectives and summary of research on seven research projects.Joint Services Electronics Program (Contract DAAB07-76-C-1400)U. S. Navy - Office of Naval Research (Contract N00014-75-C-0951-NR 049-308)National Science Foundation (Grant ENG71-02319-AO2

Kapitalstrukturen börsennotierter Aktiengesellschaften - Deutschland und USA im Vergleich

Bisherige Evidenz über Kapitalstrukturunterschiede zwischen Deutschland und den USA deutet auf eine durchschnittlich höhere Verschuldung deutscher Unternehmen hin. Die vergangenen Jahre waren in Deutschland jedoch durch eine Förderung der Eigenkapitalfinanzierung seitens des deutschen Gesetzgebers und der Regulierungsbehörden geprägt. Die vorliegende Arbeit untersucht, inwieweit sich diese Änderungen tatsächlich auf den Verschuldungsgrad deutscher Unternehmen auswirken und ob es zu einer Annäherung an amerikanische Unternehmen kommt. Zu diesem Zweck werden durchschnittliche Verschuldungsgrade von US-amerikanischen und deutschen börsennotierten Gesellschaften über einen Zeitraum von 10 Jahren verglichen. Die Untersuchung zeigt, dass diese Änderungen vor allem den Verschuldungsgrad von Unternehmen beeinflusst haben, die erst in den letzten Jahren an einer deutschen Börse notiert wurden. Bei am deutschen Kapitalmarkt etablierten Unternehmen hingegen lässt sich keine aufgrund der neuen Rahmenbedingungen vorgenommene Anpassung der Verschuldungspolitik erkennen. Abstract Existing comparative evidence on corporate capital structure decisions in the U.S. and Germany traditionally reveals that German firms chose substantially higher levels of debt financing. Within the past years, however, Germany has experienced repeated initiatives by both legislative and regulatory bodies to promote equity finance. This paper tries to shed first light on how these initiatives affect the debt-equity-decision of German corporations and whether a convergence of German leverage levels to Anglo-American financing patterns can be observed. For this purpose we compare capital structures for a panel of U.S. and German public corporations over the past 10 years. The obtained evidence suggests that aggregate leverage ratios do indeed converge. Yet this development is primarily driven by recent German IPOs which seem to respond to the revamped institutional setting by choosing higher levels of equity. Established German corporations, by contrast, do not seem to have systematically adapted their financing patterns over the past decade

Group cognitive rehabilitation to reduce the psychological impact of multiple sclerosis on quality of life: the CRAMMS RCT

AbstractBackgroundPeople with multiple sclerosis have problems with memory and attention. The effectiveness of cognitive rehabilitation has not been established.ObjectivesThe objectives were to assess the clinical effectiveness and cost-effectiveness of a cognitive rehabilitation programme for people with multiple sclerosis.DesignThis was a multicentre, randomised controlled trial in which participants were randomised in a ratio of 6 : 5 to receive cognitive rehabilitation plus usual care or usual care alone. Participants were assessed at 6 and 12 months after randomisation.SettingThe trial was set in hospital neurology clinics and community services.ParticipantsParticipants were people with multiple sclerosis who had cognitive problems, were aged 18–69 years, could travel to attend group sessions and gave informed consent.InterventionThe intervention was a group cognitive rehabilitation programme delivered weekly by an assistant psychologist to between four and six participants for 10 weeks.Main outcome measuresThe primary outcome was the Multiple Sclerosis Impact Scale – Psychological subscale at 12 months. Secondary outcomes included results from the Everyday Memory Questionnaire, the 30-Item General Health Questionnaire, the EuroQol-5 Dimensions, five-level version and a service use questionnaire from participants, and the Everyday Memory Questionnaire – relative version and the Modified Carer Strain Index from a relative or friend of the participant.ResultsOf the 449 participants randomised, 245 were allocated to cognitive rehabilitation (intervention group) and 204 were allocated to usual care (control group). Of these, 214 in the intervention group and 173 in the control group were included in the primary analysis. There was no clinically important difference in the Multiple Sclerosis Impact Scale – Psychological subscale score between the two groups at the 12-month follow-up (adjusted difference in means –0.6, 95% confidence interval –1.5 to 0.3; p = 0.20). There were no important differences between the groups in relation to cognitive abilities, fatigue, employment, or carer strain at follow-up. However, there were differences, although small, between the groups in the Multiple Sclerosis Impact Scale – Psychological subscale score at 6 months (adjusted difference in means –0.9, 95% confidence interval –1.7 to –0.1; p = 0.03) and in everyday memory on the Everyday Memory Questionnaire as reported by participants at 6 (adjusted difference in means –5.3, 95% confidence interval –8.7 to –1.9) and 12 months (adjusted difference in means –4.4, 95% confidence interval –7.8 to –0.9) and by relatives at 6 (adjusted difference in means –5.4, 95% confidence interval –9.1 to –1.7) and 12 months (adjusted difference in means –5.5, 95% confidence interval –9.6 to –1.5) in favour of the cognitive rehabilitation group. There were also differences in mood on the 30-Item General Health Questionnaire at 6 (adjusted difference in means –3.4, 95% confidence interval –5.9 to –0.8) and 12 months (adjusted difference in means –3.4, 95% confidence interval –6.2 to –0.6) in favour of the cognitive rehabilitation group. A qualitative analysis indicated perceived benefits of the intervention. There was no evidence of a difference in costs (adjusted difference in means –£574.93, 95% confidence interval –£1878.93 to £729.07) or quality-adjusted life-year gain (adjusted difference in means 0.00, 95% confidence interval –0.02 to 0.02). No safety concerns were raised and no deaths were reported

Digital Signal Processing

Contains reports on twelve research projects.U. S. Navy - Office of Naval Research (Contract N00014-75-C-0951)National Science Foundation (Grant ENG76-24117)National Aeronautics and Space Administration (Grant NSG-5157)Joint Services Electronics Program (Contract DAABO7-76-C-1400)U.S. Navy-Office of Naval Research (Contract N00014-77-C-0196)Woods Hole Oceanographic InstitutionU. S. Navy - Office of Naval Research (Contract N00014-75-C-0852)Department of Ocean Engineering, M.I.T.National Science Foundation subcontract to Grant GX 41962 to Woods Hole Oceanographic Institutio

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

notes: PMCID: PMC3446315© 2012 Davies et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Dynamic changes to the epigenome play a critical role in establishing and maintaining cellular phenotype during differentiation, but little is known about the normal methylomic differences that occur between functionally distinct areas of the brain. We characterized intra- and inter-individual methylomic variation across whole blood and multiple regions of the brain from multiple donors