Comparison of the oxidative potential of primary (POA) and secondary (SOA) organic aerosols derived from α-pinene and gasoline engine exhaust precursors [version 1; referees: 2 approved]

Background: Primary (POA) and secondary (SOA) organic aerosols, deriving from both anthropogenic and biogenic sources, represent a major fraction of ambient particulate matter (PM) and play an important role in the etiology of respiratory and cardiovascular diseases, largely through systemic inflammation and cellular oxidative stress. The relative contributions of these species to the inhalation burden, however, are rather poorly characterized. In this study, we measured the in vitro oxidative stress response of alveolar macrophages exposed to primary and secondary PM derived from both anthropogenic and biogenic sources. Methods: POA and SOA were generated within an oxidation flow reactor (OFR) fed by pure, aerosolized α-pinene or gasoline engine exhaust, as representative emissions of biogenic and anthropogenic sources, respectively. The OFR utilized an ultraviolet (UV) lamp to achieve an equivalent atmospheric aging process of several days. Results: Anthropogenic SOA produced the greatest oxidative response (1900 ± 255 µg-Zymosan/mg-PM), followed by biogenic (α-pinene) SOA (1321 ± 542 µg-Zymosan/mg-PM), while anthropogenic POA produced the smallest response (51.4 ± 64.3 µg-Zymosan/mg-PM). Conclusions: These findings emphasize the importance of monitoring and controlling anthropogenic emissions in the urban atmosphere, while also taking into consideration spatial and seasonal differences in SOA composition. Local concentrations of biogenic and anthropogenic species contributing to the oxidative potential of ambient PM may vary widely, depending on the given region and time of year, due to factors such as surrounding vegetation, proximity to urban areas, and hours of daylight

Comparison of the oxidative potential of primary (POA) and secondary (SOA) organic aerosols derived from α-pinene and gasoline engine exhaust precursors [version 2; referees: 2 approved]

Background: Primary (POA) and secondary (SOA) organic aerosols, deriving from both anthropogenic and biogenic sources, represent a major fraction of ambient particulate matter (PM) and play an important role in the etiology of respiratory and cardiovascular diseases, largely through systemic inflammation and cellular oxidative stress. The relative contributions of these species to the inhalation burden, however, are rather poorly characterized. In this study, we measured the in vitro oxidative stress response of alveolar macrophages exposed to primary and secondary PM derived from both anthropogenic and biogenic sources. Methods: POA and SOA were generated within an oxidation flow reactor (OFR) fed by pure, aerosolized α-pinene or gasoline engine exhaust, as representative emissions of biogenic and anthropogenic sources, respectively. The OFR utilized an ultraviolet (UV) lamp to achieve an equivalent atmospheric aging process of several days. Results: Anthropogenic SOA produced the greatest oxidative response (1900 ± 255 µg-Zymosan/mg-PM), followed by biogenic (α-pinene) SOA (1321 ± 542 µg-Zymosan/mg-PM), while anthropogenic POA produced the smallest response (51.4 ± 64.3 µg-Zymosan/mg-PM). Conclusions: These findings emphasize the importance of monitoring and controlling anthropogenic emissions in the urban atmosphere, while also taking into consideration spatial and seasonal differences in SOA composition. Local concentrations of biogenic and anthropogenic species contributing to the oxidative potential of ambient PM may vary widely, depending on the given region and time of year, due to factors such as surrounding vegetation, proximity to urban areas, and hours of daylight

Waterpipe tobacco smoking: An emerging health crisis in the United States

Objective: To examine the prevalence and potential health risks of waterpipe tobacco smoking. Methods: A literature review was performed to compile information relating to waterpipe tobacco smoking. Results: Waterpipe tobacco smoking is increasing in prevalence worldwide; in the United States, 10-20% of some young adult populations are current waterpipe users. Depending on the toxicant measured, a single waterpipe session produces the equivalent of at least 1 and as many as 50 cigarettes. Misconceptions about waterpipe smoke content may lead users to underestimate health risks. Conclusion: Inclusion of waterpipe tobacco smoking in tobacco control activities may help reduce its spread. Copyright © PNG Publications 2011 All Rights Reserved

A geostatistical approach for assessing population exposure to NO2 in a complex urban area (Beirut, Lebanon).

International audienceFew studies in the Middle East region estimated the spatial distribution of air pollutants for exposure studies. This paper presents a geostatistical approach to assess background NO2 spatial distribution and the associated exposed population in a Mediterranean city with a complex topography, Beirut. Such modeling gave an accurate mapping of the 2010 yearly background average value of NO2: it varies between 35 and 67 μg m−3 with a mean of 53 μg m−3. The mean SD of the estimated error was about 3 μg m−3. The results showed that the spatial distribution of NO2 follows a nested structuring, with a major structure related to topoclimatic characteristics (interaction topography/atmospheric flow at large scale) and a minor one linked to micro-environment and micro-climatic characteristics (interactions urban morphology/atmospheric flows at fine scale). The probability for the city's inhabitants to be exposed to NO2 levels exceeding 40 μg m−3 threshold limit set by the World Health Organization (WHO) showed that Beirut city has a real sanitary risk to the NO2 pollution. 93 % of the population (around 358,459 people) is 100 % sure to be exposed to a yearly average exceeding 40 μg m−3. This knowledge will be certainly useful for developing a tool for decision support in order to implement policies of reducing air pollution in Beirut, which is, given the results, very urgent

Nicotine exposure in daily waterpipe smokers and its relation to puff topography

Waterpipe tobacco smoking is increasing in popularity worldwide and available evidence point to its addictive and harmful potential. This study is conducted to assess nicotine exposure in daily waterpipe smokers, and its correlation with puff topography parameters. Sixty-one waterpipe tobacco smokers (56 males; mean age ± SD, 30.9 ± 9.5. years; mean number of weekly waterpipe smoking episodes 7.8 ± 5.7) abstained from smoking for at least 24. h, and then smoked tobacco from a waterpipe ad libitum in a laboratory setting. During the session puff topography parameters were monitored continuously, and pre- and post-smoking expired-air CO was measured. Before and after smoking, venous blood was sampled for the assessment of plasma nicotine using Gas Chromatography-Mass Spectrometry. The average pre- and post-smoking expired-air CO was 4 ± 1.7 and 35.5 ± 32.7. ppm, respectively (i.e., a CO boost of 31.5. ppm, p\u3c .001). Mean plasma nicotine concentration increased from 3.07 ± 3.05. ng/ml pre-smoking to 15.7 ± 8.7. ng/ml post-smoking (p\u3c .001). Plasma nicotine boost was correlated with total session time (Pearson correlation coefficient r = .31, p=.04), cumulative puff duration (r = .37, p = .01), mean puff duration (r = .34, p = .02), and total smoke inhaled in the session (r = .34, p = .02. These data show considerable nicotine exposure in daily waterpipe smokers, and that nicotine exposure is a function of waterpipe smoking patterns. © 2010 Elsevier Ltd

Intraurban Variability of PM10 and PM2.5 in an eastern Mediterranean city

International audienceThe results of the first large scale chemical characterization of PM10 and PM2.5 at three different sites in the urban city of Beirut, Lebanon, are presented. Between May 2009 and April 2010 a total of 304 PM10 and PM2.5 samples were collected by sampling every sixth day at three different sites in Beirut. Observed mass concentrations varied between 19.7 and 521.2 μg m− 3 for PM10 and between 8.4 and 72.2 μg m− 3 for PM2.5, respectively. Inorganic concentrations accounted for 29.7-35.6 μg m− 3 and 46.0-53.5 μg m− 3 of the total mass of PM10 and PM2.5, respectively. Intra-city temporal and spatial variations were assessed based on the study of three factors: correlation coefficients (R) for PM and chemical components, coefficient of divergence (CODs), and source apportionment using positive matrix factorization (PMF). Based on R and COD of PM concentrations, the three sites appear homogeneous. However, when individual elements were compared, heterogeneity among sites was found. This latter was attributed to the variability in the percent contribution of biogenic and local anthropogenic source factors such as traffic related sources and dust resuspension. Other factors included the proximity to the Mediterranean sea, the population density and the topographical structure of the city. Hence, despite its small size (20.8 km2), one PM monitoring site does not reflect an accurate PM level in Beirut

Exposure to atmospheric pms, pahs, pcdd/fs and metals near an open air waste burning site in Beirut

Baalbaki, R., El Hage, R., Nassar, J., Gerard, J., Saliba, N.B., Zaarour, R., Abboud, M., Wehbeh, F., Khalaf, L.K., Shihadeh, A.L., Saliba, N.A. 2016. Exposure to atmospheric PMS, PAHS, PCDD/FS and metals near an open air waste burning site in Beirut. Lebanese Science Journal, 17(2): 91-103. Since July 2015, Lebanon has experienced the worst solid waste management crisis in its history. Consequently, open-air waste burning in the vicinity of highly populated areas in Beirut has become a common practice. This study evaluates the effects of open-air dumping and burning on local air quality and public health. The levels of particulate matter (PM10, PM2.5), gaseous and particle-bound polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-dioxins and furans (PCDD/Fs), and particle-bound metals at a residence close to waste burning are reported. Concentrations, determined between October 2 and December 2, 2015, were compared either to previous measurements or to measurements taken away from a nearby burning incident, and after it had rained. Subsequently, the cancer risk due to exposure to these chemicals was assessed. Results showed alarming increases in pollutant concentrations which was translated into an increase in short-term cancer risk from about 1 to 20 people per million on the days when waste was being burned. Findings were shared with the public to warn the community against the dangers of waste mismanagement, and underline the obvious need for solid waste management at the governmental and municipal levels

NIH Workshop Report: E-cigarette or Vaping Product Use Associated Lung Injury (EVALI): Developing a Research Agenda

The NHLBI convened a working group on October 23, 2019, to identify the most relevant and urgent research priorities and prevailing challenges in e-cigarette or vaping product use-associated lung injury (EVALI). Experts across multiple disciplines discussed the complexities of the EVALI outbreak, identified research priorities, and recommended strategies to address most effectively its causal factors and improve diagnosis, treatment, and prevention of this disease. Many research priorities were identified, including the need to create national and international registries of patients with EVALI, to track accurately those affected and assess outcomes. The group concluded that biospecimens from subjects with EVALI are urgently needed to help define EVALI pathogenesis and that vaping has disease risks that are disparate from smoking, with the occurrence of EVALI highlighting the importance of broadening e-cigarette research beyond comparators to smoking-related diseases