Frequency of Technical Problems Encountered in the Measurement of Pulmonary Artery Wedge Pressure

journal articleBiomedical Informatic

Dynamic Response and the Essentials of Invasive Blood Pressure Monitoring

pamphletBiomedical Informatic

Speech Communication

Contains research objectives, summary of research and reports on one research project.U.S. Air Force Cambridge Research Laboratories, Office of Aerospace Research, under Contract F19628-69-C-0044National Institutes of Health (Grant 2 RO1 NB-04332-07

Dynamical description of vesicle growth and shape change

We systematize and extend the description of vesicle growth and shape change using linear nonequilibrium thermodynamics. By restricting the study to shape changes from spheres to axisymmetric ellipsoids, we are able to give a consistent formulation which includes the lateral tension of the vesicle membrane. This allows us to generalize and correct a previous calculation. Our present calculations suggest that, for small growing vesicles, a prolate ellipsoidal shape should be favored over oblate ellipsoids, whereas for large growing vesicles oblates should be favored over prolates. The validity of this prediction is examined in the light of the various assumptions made in its derivation.Comment: 6 page

Development of mucoadhesive sprayable gellan gum fluid gels

The nasal mucosa provides a potentially good route for local and systemic drug delivery. However, the protective feature of the nasal cavity make intranasal delivery challenging. The application of mucoadhesive polymers in nasal drug delivery systems enhances the retention of the dosage form in the nasal cavity. Several groups have investigated using low acyl gellan as a drug delivery vehicle but only limited research however, has been performed on high acyl gellan for this purpose, despite its properties being more conducive to mucoadhesion. High acyl gellan produces highly elastic gels below 60 °C which make it difficult to spray using a mechanical spray device. Therefore, in this study we have tried to address this problem by making fluid gels by introducing a shear force during gelation of the gellan polymer. These fluid gel systems contain gelled micro-particles suspended in a solution of un-gelled polymer. These systems can therefore behave as pourable viscoelastic fluids. In this study we have investigated the rheological behavior and mucoadhesion of fluid gels of two different types of gellan (high and low acyl) and fluid gels prepared from blends of high and low acyl gellan at a 50:50 ratio. The results demonstrated that by preparing fluid gels of high acyl gellan, the rheological properties were sufficient to spray through a standard nasal spray device. Moreover fluid gels also significantly enhance both high acyl and low acyl gellan mucoadhesion properties

Speech Communication

Contains research objectives, summary of research and reports on one research project.U. S. Air Force Cambridge Research Laboratories under Contract F19628-69-C-0044National Institutes of Health (Grant 2 ROl NB-04332-08)Joint Services Electronics Programs (U. S. Army, U. S. Navy, and U. S. Air Force) under Contract DA 28-043-AMC-02536(E

Speech Communication

Contains research objectives, summary of research and reports on three research projects.U. S. Navy - Office of Naval Research (Contract N00014-67-A-0204-0064)U. S. Navy - Office of Naval Research (Contract N00014-67-A-0204-0069)National Science Foundation (Grant GK-31353)National Institutes of Health (Grant 5 RO1 NS04332-10)Joint Services Electronics Programs (U. S. Army, U. S. Navy, and U. S. Air Force) under Contract DAAB07-71-C-0300Bell Telephone Laboratories Fellowshi