Errors and omissions in learning. Classical worlds and modern society

En esta comunicación presentaremos someramente los resultados obtenidos en la primera fase del proyecto «Los mundos clásicos en la sociedad actual. Errores y omisiones que dificultan el aprendizaje». El ámbito de aplicación consiste en el alumnado de varias asignaturas del grado en Estudios clásicos y de otros grados en los que impartimos docencia, como el grado en Estudios ingleses o un grupo específico para el aprendizaje del latín: Latín nivel 0. El objetivo era detectar y valorar las carencias que dificultan el aprendizaje y la adquisición de competencias relacionadas con la influencia de los mundos clásicos (greco-latino y árabe) en la sociedad actual, así como trazar con claridad el perfil del alumnado que cursaba estas asignaturas. Para ello necesitábamos saber la concepción y conocimientos que poseían sobre los mundos clásicos. El método que utilizamos fue una encuesta doble con una parte centrada en el mundo clásico grecolatino y otra, paralela, dedicada al mundo árabe clásico. El análisis de los resultados permitió concluir que asocian mundo clásico a historia, mitología, cultura o cocina, pero no a la lengua; que la mayoría conoce la mitología porque es un tema de gran interés para los medios de entretenimiento (cine, televisión, videojuegos) que son la fuente de su conocimiento. En el caso del árabe, su interés se centra en temas culturales en los que se integra la religión considerada un aspecto cultural más, pues su conocimiento procede de los medios de entretenimiento entre los que mencionan libros de lectura como las novelasIn this paper we will briefly present the results obtained in the first phase of the project «The Classical Worlds in Today’s Society. Errors and omissions that make learning difficult». The scope of application consists of the students of several subjects of the degree in Classical Studies and of other degrees in which we participate, as the degree in English Studies or a specific group for the learning of Latin, Latin level 0. The objective was to detect the deficiencies that make learning difficult and to acquire competences related to the influence of the classical worlds (Greco-Latin and Arabic) in modern society, as well as to outline the profile of the students who studied these subjects. We needed to know the conception and knowledge they had on the classical world. The method we used was a double survey with one part centered on the classic Greco-Roman world and another dedicated to the classical Arab world. The analysis of the results allowed to conclude they associate classic world with history, mythology, culture or cuisine, but not with language; the majority knows mythology because it is a subject of great interest for the entertainment media (cinema, television, video games), main source of its knowledge. In the case of Arabic world, their interest is focused on cultural issues in which religion is considered a cultural aspect, since their knowledge comes from the entertainment media as cinema, video games and novels

Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score

We  examined the predictive ability of the new thrombophilia-based genetic risk score that has been developed (TiC-RPL)  to acutely determine the risk of recurrent pregnancy loss (RPL) closely related to thrombophilia and to compare it with the ability of the classical genetic thrombophilia variants F5 rs6025 and F2 rs1799963. This is a case-control observational study, with retrospective data analysis. We included 180 healthy women with at least one uncomplicated pregnancy to term and no previous miscarriage and 184 cases of idiopathic recurrent pregnancy loss (RPL). The predictive ability was assessed in terms of discrimination (AUC), sensitivity, specificity, positive and negative predictive values (PPV, NPV), and positive and negative likelihood ratios (PLR and NLR). TiC-RPL has a better AUC (95 CI) than F5 rs6025+F2 rs1799963 [0.763 (0.715-0.811) vs 0.540 (0.514-0.567); p<0.0001], with a sensitivity of 70.65%, a specificity of 67.78%, a PPV of 69.15%, an NPV of 69.32%, a PLR of 2.19, and an NLR of 0.43. Our results show that the new score TiC-RPL is significantly better than F5 rs6025+F2 rs1799963 in identifying RPL women in whom RPL appears to be associated with thrombophilia. This identification can guide a personalized approach in the prevention of RPL

A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos

This study has analysed the relationship between ovarian response and the number of euploid embryos. This is a post hoc analysis of a subset of data generated during a prospective cohort study previously published. Forty-six oocyte donors were subjected to ovarian stimulation with 150 IU of rFSH and 75 IU of hp-hMG in a GnRH agonist long protocol. Preimplantation genetic screening was performed in all viable embryos. We observed a positive relationship between ovarian response and the number of euploid embryos. When ovarian response was above the median (≥17 oocytes), the mean number of euploid embryos per donor was 5.0 ± 2.4, while when <17 oocytes were obtained the mean number of euploid embryos was 2.7 ± 1.4 ( = 0.000). Aneuploidy rate did not increase with ovarian response or gonadotropin doses. Also, the number of euploid embryos was inversely related to the amount of gonadotropins needed per oocyte obtained (ovarian sensitivity index). These results suggest that the number of euploid embryos available for embryo transfer increases as the number of oocytes obtained does. Considering the total number of euploid embryos seems more relevant than the aneuploidy rate

A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos

This study has analysed the relationship between ovarian response and the number of euploid embryos. This is a post hoc analysis of a subset of data generated during a prospective cohort study previously published. Forty-six oocyte donors were subjected to ovarian stimulation with 150 IU of rFSH and 75 IU of hp-hMG in a GnRH agonist long protocol. Preimplantation genetic screening was performed in all viable embryos. We observed a positive relationship between ovarian response and the number of euploid embryos. When ovarian response was above the median (≥17 oocytes), the mean number of euploid embryos per donor was 5.0 ± 2.4, while when <17 oocytes were obtained the mean number of euploid embryos was 2.7 ± 1.4 (p=0.000). Aneuploidy rate did not increase with ovarian response or gonadotropin doses. Also, the number of euploid embryos was inversely related to the amount of gonadotropins needed per oocyte obtained (ovarian sensitivity index). These results suggest that the number of euploid embryos available for embryo transfer increases as the number of oocytes obtained does. Considering the total number of euploid embryos seems more relevant than the aneuploidy rate

Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility

Adenomyosis is related to infertility and miscarriages, but so far there are no robust in vitro models that reproduce its pathological features to study the molecular mechanisms involved in this disease. Endometrial organoids are in vitro 3D models that recapitulate the native microenvironment and reproduce tissue characteristics that would allow the study of adenomyosis pathogenesis and related infertility disorders. In our study, human endometrial biopsies from adenomyosis (n = 6) and healthy women (n = 6) were recruited. Organoids were established and hormonally differentiated to recapitulate midsecretory and gestational endometrial phases. Physiological and pathological characteristics were evaluated by immunohistochemistry, immunofluorescence, qRT-PCR, and ELISA. Secretory and gestational organoids recapitulated in vivo glandular epithelial phenotype (pan-cytokeratin, Muc-1, PAS, Laminin, and Ki67) and secretory and gestational features (α-tubulin, SOX9, SPP1, PAEP, LIF, and 17βHSD2 expression and SPP1 secretion). Adenomyosis organoids showed higher expression of TGF-β2 and SMAD3 and increased gene expression of SPP1, PAEP, LIF, and 17βHSD2 compared with control organoids. Our results demonstrate that organoids derived from endometria of adenomyosis patients and differentiated to secretory and gestational phases recapitulate native endometrial-tissue-specific features and disease-specific traits. Adenomyosis-derived organoids are a promising in vitro preclinical model to study impaired implantation and pregnancy disorders in adenomyosis and enable personalized drug screening

VII Jornadas de Innovación Educativa de la Universidad de La Laguna: imaginar y comprender la innovación en la Universidad

The change of structure and process of the organizations of the current society has generated a great impact in the new way of working. Work teams coordination ensures that a team functions as a unitary whole; is identified as a key process to understand work team effectiveness. This paper presents a brief introduction of the recent research on Work teams in organizations and raises relevant issues about their implications for Pedagogy studies. This paper aims, first, to analyze the potential of team based organizations. And secondly, to examine the effects in pedagogy studies. Coordination is a process that involves the use of strategies and patterns of behavior aimed to integrate actions, knowledge and goals of interdependent members. The tasks have increased its difficulty, doing that individual resolution is very difficult or impossibleUniversidad de La Lagun