Growth and Development of Entrepreneurship in Nigeria: An Investigation of Microfinance from the Rural Settings

This study focused on the significance of microfinance to growth and development of entrepreneurship in rural settings of Nigeria. The study determined the role of microfinance on the economic development of the rural areas of Nigeria. For these purposes, survey research was explored, using well structured questionnaires. The universe of the study (80 respondents) consisted of 55 selected SMEs and 25 will-be entrepreneurs in some rural areas of Nigeria, particularly, Kogi State; and the sample size (67) was determined using Taro Yamane sampling method. Bowler’s proportional allocation method was further employed to ensure objective questionnaires distribution process. This study analyzed the data collected in tables with percentage method, and used Chi-Square for hypotheses testing. Findings revealed that microfinance is significant to the growth and development of entrepreneurship, and equally, economic development in the rural settlements of Nigeria. It was concluded that small scale agricultural practice and micro-small scale enterprises are developing in the rural settlements. This makes microfinance significant to the growth and development of entrepreneurship, and equally the economic development in the rural settings of Nigeria. The study therefore recommends that the government should design and implement policies and programmes that are capable of serving as road map for effective and efficient microfinance services in the rural settlements of Nigeria, and that entrepreneurs should carefully manage microfinance facilities to combat peculiar challenges facing their entrepreneurial activities and economic development. Keywords: Rural Entrepreneurs, Microfinance, Economic Development, Financial Products, Small Scale Enterprise

Small Scale Enterprisesand the Economic Siamese of Nigeria: Growth-Barrier Chain Analysis

This study investigated the SME growth-barrier chain in Nigeria. A target population of 39,600 was sampled using Taro Yamane method to achieve the surveyed 396 respondents. A well structured questionnaire was administered to collect the data. Percentage, descriptive, Likert analysis and regression analysis were used to explain the nature of the SME growth-barrier chain in Nigeria. Results of the study reveal that barrier factors have been influencing SMEs growth in Nigeria, and that the most significant among the barrier factors are entrepreneurial skill, irregular power supply and lack of business strategy. This study is limited by sample size and selection of SMEs at their clustered areas, and therefore may not be generalized to other sectors and countries. The study concludes that these factors cause epileptic growth or sudden death of SMEs in Nigeria. The study recommends that the government should engage in intervention programmes, and also ensure regular power supply in Nigeria. In addition, SME owner-managers should adopt and implement business strategies in their business environment. Keywords: SMEs growth. Barrier factors, employment, Business Strategy, Entrepreneurial Skil

Structure: Activity and Emerging Applications of Spices and Herbs

Herbs and spices are plant parts (herbs from leaves and spices from other parts) that are conventionally used in their fresh or dried state for flavouring, natural condiments, preservatives and for medicinal purposes. Worldwide, most spices are classified on the basis of taste, season of growth, economic importance, growth habit and plant part used. Black pepper, chilies, small cardamom, ginger and turmeric are some of the widely used spices while common herbs include thyme, basil and bay leaves. These herbs are basically classified according to usage, active constituents and period of life. Secondary metabolites such as Eugenol, thymol, limonene, cuminaldehyde, curcumin, piperine, quercetin, luteolin in these plant parts have been found to be responsible for anticancer, antimicrobial, antiviral, antidiabetic, antioxidant, anti-inflammatory and hypocholesterolemic effects. Their application in water fortification, milk and cheese processing, production of beauty products and pesticides among others could not be underestimated. Finally, adulteration, toxicity and allergic reactions are some of the identified limitations and challenges often encountered in the use of herbs and spices

Global Retinoblastoma Presentation and Analysis by National Income Level.

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs

The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries

DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt

Predictors and consequences of early sexual debut among students in tertiary institutions in Lagos metropolis, Nigeria

This study investigated the factors associated with early sexual debut, consensual sexual debut and multiple sexual partners in tertiary institutions in Lagos Metropolis, Nigeria. The study adopted a cross-sectional survey design with a proportional sampling method. Structured questionnaire was used to elicit information from respondents. Four hundred and thirty-three questionnaires were deemed eligible for data analysis. Chi-square, t-test and binary logistic regression were utilised to analyse the data. It was found that respondents who attended private secondary schools were more likely to have early sexual debut (X2= 3.076; p<0.05). There was no significant difference in the age at sexual debut for respondents from nuclear and extended families (M.D = -0.377). Females were less likely to experience consensual sexual debut than their male counterparts (OR=0.469; p<0.01). Also, early sexual debut influenced exposure to multiple sexual partners- those who delayed sex till age 22 were the least likely to be exposed (OR= 0.056; p<0.001). Adequate sex education of young people-beginning at early years- before their sexual debut is important for improved sexual health. Keywords: Sexual debut, multiple sexual partners, consensual sex, undergraduates; family type; Nigeria   Cette étude a examiné les facteurs associés aux débuts sexuels précoces, aux débuts sexuels consensuels et aux partenaires sexuels multiples dans des établissements tertiaires de Lagos Metropolis, au Nigéria. L'étude a adopté un plan d'enquête transversal avec une méthode d'échantillonnage proportionnel. Un questionnaire structuré a été utilisé pour obtenir des informations auprès des répondants. Quatre cent trente-trois questionnaires ont été jugés éligibles pour l'analyse des données. Le chi carré, le test t et la régression logistique binaire ont été utilisés pour analyser les données. Il a été constaté que les répondants qui fréquentaient des écoles secondaires privées étaient plus susceptibles d'avoir des débuts sexuels précoces (X2 = 3,076; p <0,05). Il n'y avait pas de différence significative d'âge au début des rapports sexuels pour les répondants issus de familles nucléaires et élargies (M.D = -0,377). Les femmes étaient moins susceptibles d'avoir des débuts sexuels consensuels que leurs homologues masculins (OR = 0,469; p <0,01). En outre, les débuts sexuels précoces ont influencé l'exposition à plusieurs partenaires sexuels - ceux qui ont retardé les rapports sexuels jusqu'à l'âge de 22 ans étaient les moins susceptibles d'être exposés (OR = 0,056; p <0,001). Une éducation sexuelle adéquate des jeunes - dès les premières années - avant leurs débuts sexuels est importante pour une meilleure santé sexuelle. Mots-clés: Débuts sexuels, partenaires sexuels multiples, rapports sexuels consensuels, étudiants de premier cycle; type de famille; Nigeri

ROASTED AFRICAN STAR APPLE (Chrysophyllum albidum) KERNEL MEAL IMPROVES GROWTH PERFORMANCE OF GROWING RABBITS

Nutritionally, Chrysophyllum albidum seeds have been reported to contain high amount of energy. However, the presence of anti-nutritional substances such as phytate, oxalate, saponin, and tannin in the seeds hinder animals from benefitting from it nutritionally. A 12-week study was carried out to examine the effect of substituting dietary maize with roasted African star apple kernel meal (RASAKM) on growth performance and blood indices of growing rabbits. A total of forty eight weaner rabbits (mixed breed, average weight, 590 g) were randomly allocated to four experimental diets containing 0, 5, 10 and 15 % RASAKM as substitute for dietary maize in a Completely Randomized Design. Roasted ASAKM influenced (P0.05) weight gain (17.47 g and 16.69 g) with those fed the control diet (18.62 g). Rabbits fed 5 and 10 % RASAKM diets produced higher (P0.05) by the dietary treatments except for white blood cell and monocytes. It was concluded that RASAKM could be used up to 10 % to replace dietary maize in the diet of growing rabbits without compromising performance and carcass quality

Plant active products and emerging interventions in water potabilisation: disinfection and multi-drug resistant pathogen treatment

Abstract Background This review aims at establishing the emerging applications of phytobiotics in water treatment and disinfection. Results Statistical analysis of data obtained revealed that the use of plant product in water treatment needs more research attention. A major observation is that plants possess multifaceted components and can be sustainably developed into products for water treatment. The seed (24.53%), flower (20.75), leaf (16.98%) and fruit (11.32%) biomasses are preferred against bulb (3.77%), resin (1.89%), bark (1.89%) and tuber (1.89%). The observation suggests that novel applications of plant in water treatment need further exploration since vast and broader antimicrobial activities (63.63%) is reported than water treatment application (36.37%). Conclusions This review has revealed the existing knowledge gaps in exploration of plant resources for water treatment and product development. Chemical complexity of some plant extracts, lack of standardisation, slow working rate, poor water solubility, extraction and purification complexities are limitations that need to be overcome for industrial adoption of phytochemicals in water treatment. The field of phytobiotics should engage modern methodologies such as proteomics, genomics, and metabolomics to minimise challenges confronting phytobiotic standardisation. The knowledge disseminated awaits novel application for plant product development in water treatment