The RNA editing enzyme ADAR2 restricts L1 mobility

Adenosine deaminases acting on RNA (ADARs) are enzymes that convert adenosines to inosines in double-stranded RNAs (RNA editing A-to-I). ADAR1 and ADAR2 were previously reported as HIV-1 proviral factors. The aim of this study was to investigate the composition of the ADAR2 ribonucleoprotein complex during HIV-1 expression. By using a dual-tag affinity purification procedure in cells expressing HIV-1 followed by mass spectrometry analysis, we identified 10 non-ribosomal ADAR2-interacting factors. A significant fraction of these proteins was previously found associated to the Long INterspersed Element 1 (LINE1 or L1) ribonucleoparticles and to regulate the life cycle of L1 retrotransposons. Considering that we previously demonstrated that ADAR1 is an inhibitor of LINE-1 retrotransposon activity, we investigated whether also ADAR2 played a similar function. To reach this goal, we performed specific cell culture retrotransposition assays in cells overexpressing or ablated for ADAR2. These experiments unveil a novel function of ADAR2 as suppressor of L1 retrotransposition. Furthermore, we showed that ADAR2 binds the basal L1 RNP complex. Overall, these data support the role of ADAR2 as regulator of L1 life cycle

Physical and geometrical parameters of the binary system gliese 150.2

The speckle interferometric binary system Gl 150.2 (HIP17491) is analyzed using atmosphere modeling and dynamical analysis simultaneously. A synthetic spectral energy distribution (SED) for each of the two components of the system is built using Kurucz blanketed models. These SEDs are combined together to form the total flux, which is compared with the observed one in an iterative method to get the best fit. The parameters of the individual components which lead to the best fit are: T eff A = 5350 ± 50 K, T eff B = 4400 ± 50 K, log g A = 4.40 ± 0.05, log g B = 4.68 ± 0.05, R A = 0.95 ± 0.06R ⊙, R B = 0.58 ± 0.06R ⊙, and π = 38.63 ± 0.79 mas, as given by the modified Hipparcos measurement. A modified orbit of the system is introduced and compared with earlier orbits. Hence, the masses of the two components are derived from the coincidence between the atmosphere modeling and dynamical analysis. Based on the estimated physical and geometrical parameters of the system, which are confirmed by synthetic photometry, the spectral types and luminosity classes of the two components are found to be G9.5V and K7V for the primary and secondary stars respectively, with an age of about 8 Gyr. Finally, the positions of both components on the H-R diagram are plotted, and the formation and evolution of the system are discussed. © 2014 Pleiades Publishing, Ltd

Investigation of Some Physical Properties of Accretion Induced Collapse in Producing Millisecond Pulsars

We investigate some physical characteristics of Millisecond Pulsar (MSP) such as magnetic fields, spin periods and masses, that are produced by Accretion Induced Collapse (AIC) of an accreting white dwarf (WD) in stellar binary systems. We also investigate the changes of these characteristics during the mass-transfer phase of the system in its way to become a MSP. Our approach allows us to follow the changes in magnetic fields and spin periods during the conversion of WDs to MSPs via AIC process. We focus our attention mainly on the massive binary WDs (M > 1.0Msun) forming cataclysmic variables, that could potentially evolve to reach Chandrasekhar limit, thereafter they collapse and become MSPs. Knowledge about these parameters might be useful for further modeling of the observed features of AIC.Comment: 9 Pages, 4 figure

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health targets, such as the Sustainable Development Goals. For three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has filled that need. A global network of collaborators contributed to the production of GBD 2021 by providing, reviewing, and analysing all available data. GBD estimates are updated routinely with additional data and refined analytical methods. GBD 2021 presents, for the first time, estimates of health loss due to the COVID-19 pandemic. Methods The GBD 2021 disease and injury burden analysis estimated years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries using 100 983 data sources. Data were extracted from vital registration systems, verbal autopsies, censuses, household surveys, disease-specific registries, health service contact data, and other sources. YLDs were calculated by multiplying cause-age-sex-location-year-specific prevalence of sequelae by their respective disability weights, for each disease and injury. YLLs were calculated by multiplying cause-age-sex-location-year-specific deaths by the standard life expectancy at the age that death occurred. DALYs were calculated by summing YLDs and YLLs. HALE estimates were produced using YLDs per capita and age-specific mortality rates by location, age, sex, year, and cause. 95% uncertainty intervals (UIs) were generated for all final estimates as the 2·5th and 97·5th percentiles values of 500 draws. Uncertainty was propagated at each step of the estimation process. Counts and age-standardised rates were calculated globally, for seven super-regions, 21 regions, 204 countries and territories (including 21 countries with subnational locations), and 811 subnational locations, from 1990 to 2021. Here we report data for 2010 to 2021 to highlight trends in disease burden over the past decade and through the first 2 years of the COVID-19 pandemic. Findings Global DALYs increased from 2·63 billion (95% UI 2·44–2·85) in 2010 to 2·88 billion (2·64–3·15) in 2021 for all causes combined. Much of this increase in the number of DALYs was due to population growth and ageing, as indicated by a decrease in global age-standardised all-cause DALY rates of 14·2% (95% UI 10·7–17·3) between 2010 and 2019. Notably, however, this decrease in rates reversed during the first 2 years of the COVID-19 pandemic, with increases in global age-standardised all-cause DALY rates since 2019 of 4·1% (1·8–6·3) in 2020 and 7·2% (4·7–10·0) in 2021. In 2021, COVID-19 was the leading cause of DALYs globally (212·0 million [198·0–234·5] DALYs), followed by ischaemic heart disease (188·3 million [176·7–198·3]), neonatal disorders (186·3 million [162·3–214·9]), and stroke (160·4 million [148·0–171·7]). However, notable health gains were seen among other leading communicable, maternal, neonatal, and nutritional (CMNN) diseases. Globally between 2010 and 2021, the age-standardised DALY rates for HIV/AIDS decreased by 47·8% (43·3–51·7) and for diarrhoeal diseases decreased by 47·0% (39·9–52·9). Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). Between 2010 and 2021, among the 25 leading Level 3 causes, age-standardised DALY rates increased most substantially for anxiety disorders (16·7% [14·0–19·8]), depressive disorders (16·4% [11·9–21·3]), and diabetes (14·0% [10·0–17·4]). Age-standardised DALY rates due to injuries decreased globally by 24·0% (20·7–27·2) between 2010 and 2021, although improvements were not uniform across locations, ages, and sexes. Globally, HALE at birth improved slightly, from 61·3 years (58·6–63·6) in 2010 to 62·2 years (59·4–64·7) in 2021. However, despite this overall increase, HALE decreased by 2·2% (1·6–2·9) between 2019 and 2021. Interpretation Putting the COVID-19 pandemic in the context of a mutually exclusive and collectively exhaustive list of causes of health loss is crucial to understanding its impact and ensuring that health funding and policy address needs at both local and global levels through cost-effective and evidence-based interventions. A global epidemiological transition remains underway. Our findings suggest that prioritising non-communicable disease prevention and treatment policies, as well as strengthening health systems, continues to be crucially important. The progress on reducing the burden of CMNN diseases must not stall; although global trends are improving, the burden of CMNN diseases remains unacceptably high. Evidence-based interventions will help save the lives of young children and mothers and improve the overall health and economic conditions of societies across the world. Governments and multilateral organisations should prioritise pandemic preparedness planning alongside efforts to reduce the burden of diseases and injuries that will strain resources in the coming decades

Physical and geometrical parameters of the binary system gliese 150.2

The speckle interferometric binary system Gl 150.2 (HIP17491) is analyzed using atmosphere modeling and dynamical analysis simultaneously. A synthetic spectral energy distribution (SED) for each of the two components of the system is built using Kurucz blanketed models. These SEDs are combined together to form the total flux, which is compared with the observed one in an iterative method to get the best fit. The parameters of the individual components which lead to the best fit are: T eff A = 5350 ± 50 K, T eff B = 4400 ± 50 K, log g A = 4.40 ± 0.05, log g B = 4.68 ± 0.05, R A = 0.95 ± 0.06R ⊙, R B = 0.58 ± 0.06R ⊙, and π = 38.63 ± 0.79 mas, as given by the modified Hipparcos measurement. A modified orbit of the system is introduced and compared with earlier orbits. Hence, the masses of the two components are derived from the coincidence between the atmosphere modeling and dynamical analysis. Based on the estimated physical and geometrical parameters of the system, which are confirmed by synthetic photometry, the spectral types and luminosity classes of the two components are found to be G9.5V and K7V for the primary and secondary stars respectively, with an age of about 8 Gyr. Finally, the positions of both components on the H-R diagram are plotted, and the formation and evolution of the system are discussed. © 2014 Pleiades Publishing, Ltd

Physical and geometrical parameters of the binary system gliese 150.2

The speckle interferometric binary system Gl 150.2 (HIP17491) is analyzed using atmosphere modeling and dynamical analysis simultaneously. A synthetic spectral energy distribution (SED) for each of the two components of the system is built using Kurucz blanketed models. These SEDs are combined together to form the total flux, which is compared with the observed one in an iterative method to get the best fit. The parameters of the individual components which lead to the best fit are: T eff A = 5350 ± 50 K, T eff B = 4400 ± 50 K, log g A = 4.40 ± 0.05, log g B = 4.68 ± 0.05, R A = 0.95 ± 0.06R ⊙, R B = 0.58 ± 0.06R ⊙, and π = 38.63 ± 0.79 mas, as given by the modified Hipparcos measurement. A modified orbit of the system is introduced and compared with earlier orbits. Hence, the masses of the two components are derived from the coincidence between the atmosphere modeling and dynamical analysis. Based on the estimated physical and geometrical parameters of the system, which are confirmed by synthetic photometry, the spectral types and luminosity classes of the two components are found to be G9.5V and K7V for the primary and secondary stars respectively, with an age of about 8 Gyr. Finally, the positions of both components on the H-R diagram are plotted, and the formation and evolution of the system are discussed. © 2014 Pleiades Publishing, Ltd