A molecular cytogenetic investigation of secondary abnormalities and clonal evolution in ETV6-RUNX1 positive acute lymphoblastic leukaemia

PhD ThesisThe bacterial cell wall surrounds the cytoplasmic membrane and protects the cell against osmolysis in addition to providing shape. The cell wall is comprised of peptidoglycan, repeating units of N-acetly glucosamine and N-acetyl muramic acid form glycan strands and are crosslinked by short peptides that contain both L- and D-amino acids. Owing to the unique nature of peptidoglycan, and its absence in eukaryotic organisms, the cell wall has become an important target for many antibiotics, including the β-lactams and glycopeptides. Newly synthesised peptidoglycan contains pentapeptides, which extend from the lactyl moiety of the MurNAc sugar. These chains consist of L-alanine-D-γ- glutamate/glutamine-L-lysine/meso-diaminopimelic acid-D-alanine-D-alanine. The terminal D-alanine is often lost during cell wall maturation, either as a result of the crosslinking reaction, in which the penultimate D-alanine is attached to the side-chain of a neighbouring L-lysine or meso-diaminopimelic acid by an isopeptide bond, or as a consequence of the activities of DD-carboxypeptidases, and results in a tetrapeptide. The tetrapeptide can then be trimmed further to form a tripeptide by the action of LD-carboxypeptidases. Although many DD-carboxypeptidases have been well characterised, the majority of LD-carboxypeptidases that have been studied are active only against peptidoglycan fragments and so cannot be responsible for producing the tripeptides found in the cell wall. Of the LD-carboxypeptidases active against the mature cell wall, DacB (Streptococcus pneumoniae), Csd6 (Helicobacter pylori) and Pgp2 (Campylobacter jejuni), each has been shown to be essential in maintaining cell morphology. It should be noted, however, that neither Csd6 nor Pgp2 share any sequence similarity with DacB and belong to different peptidase families. This thesis concerns the structural and biochemical characterisation of DacB, herein renamed to LdcB (LD-carboxypeptidase B). The crystal structures of the apo form of LdcB from both S. pneumoniae and Bacillus subtilis were solved, revealing a single domain, globular protein with 2 sub-domains forming a V-shaped cleft in which the active site is located. LdcB binds one zinc ion per monomer, located at the bottom of the active site, and is a member of the LAS (lysostaphin, D-Ala-D-Ala peptidases, sonic hedgehog) family of metalloproteins. Additionally, the activity of LdcB as an LDcarboxypeptidase was confirmed and the crystal structure of LdcB from S. pneumoniae ii was solved in complex with a product mimic, M-Tri-Lys(D-Asn), revealing the molecular basis for peptidoglycan recognition in this family of enzymes. Finally, the affinity of LdcB for zinc and copper has been determined and it has been shown that catalysis is not inhibited by the substitution of zinc by copper or cobalt.Sultanate of Oman Government, in particular Sultan Qaboos University Hospital for providing the fundin

Use of Herbal Medicine Among the Public in Abu Dhabi

Background: Herbal remedies have been used in traditional medicine for thousands of years to treat various human ailments. Aim: Given the rising increase in the use of herbal products among the United Arab Emirates (UAE) population, this study aims to explore the level of knowledge, attitude, and beliefs about the use of herbal medicine among the public in Abu Dhabi. Methods: A total of 410 male and female participants aged between 20 and 60+ years completed a 20-item face-to-face questionnaire that was composed of three sections. The first section of the questionnaire included demographic data (age, gender, nationality, marital status, and level of education), health status, and familiarity with herbal medicine. The second section included practices of using of herbal medicine among participants. The last section included respondents' beliefs and attitudes about herbal medicine based on its use. Results: The results of this study showed that almost half of the respondents were married and aged between 20 and 29 years. Only one-fifth of the participants were very familiar with the herbal medicine while more than one-third reported no familiarity. The results also showed that about 35% of the participants use herbal medicine. The only demographic features linked with the usage of herbal medications were age and marital state, where married respondents reported higher use of herbal medicine than unmarried. In addition, older respondents (40+ years) reported higher use compared to younger generations. Moreover, the patient's high cholesterol level was the sole connected health-related attribute. Interestingly, most users indicated that herbal medicine was recommended to them by family or friends, followed by herbalists and medical doctors. According to nonusers, the biggest deterrent to utilizing herbal remedies was being healthy and having no need for using herbal medicine, while lack of available information about herbal medicine was the second reason. The highest belief of respondents about the use of herbal medicine was their role in maintaining and promoting health. Conclusion: Although the results of this study showed that herbal medicine is moderately used in UAE, particularly by those who have hypercholesterolemia, it is important to emphasize the benefits and drawbacks of utilizing herbal remedies. Effective herbal medicine policies and health education programs must be developed. Patient counseling and education about medication use are needed to augment their awareness about their use. Keywords: herbal medicine, demographic features, hypercholesterolemi

The Effect of Job Rotation on Employees in Organizations in the UAE

Job rotation is a type of on-the-job knowledge acquiring where an employee is encouraged through a list of coursework planned to give them an extent of practical knowledge and coverage of different aspects of employment for that profession. Job rotation is a suitable development method for employees who are focusing only on common job tasks rather than a specialized professional route. It is also a way of obtaining speedy coverage and experience to a large selection of positions within a company in order to boost certain capabilities. The basic purpose of this study is to find out the impact of job rotation on employees in UAE public and private (both) organizations. For this purpose, online survey technique was used and data was gathered from 100 employees including males and females from UAE organizations. Data was analyzed through reliability, descriptive, correlation and regression analysis. The findings of the study show that job rotation has a highly significant and positive impact on employees in both the public and private sector in United Arab Emirates organizations. Job rotation creates new opportunities for employees and develops high skills in them. Introduction Nowadays, upgrading the knowledge and capabilities of personnel, equipping employees with the most up-to-date and unique capabilities, improving upon productiveness and worth-extra operations, blocking personnel skills from turning into obsolete and enhancing the coaching lifestyle. (Ortega, 2001). Job rotation is a serious component of work layout and an industrial observe normally used along with the intention of lowering monotony and building substantial inspiration. (Huang, 1999) According to Jorgensen (2005) Rotation is usually described as performing at different tasks or in numerous positions for established intervals of time. In the planned way applying lateral transfers aiming to permit employees to gain a range of information, skills and competencies and can be noticed being an on-thework training technique. (Gomez and Lorente, 2004). Therefore, it is thought to gain an effect on worker determination. Job rotation is a part of job system where the employees transfer from one position to another in a specific period of time to do different tasks compared to the previous positions. It can be defined as working in different positions and doing different tasks for a period of time in an organization in order to learn a different range of skills and knowledge. (Jorgensen et al, 2005). Also, according to Eriksson & Ortega (2006) Job rotation is an effective way to develop employees\u27 abilities . This research has been investigated in UAE organizations of how employees can benefit from job rotation. It could check with different types of rotations. Job rotation certainly is a kind of on-thecareer knowledge enhancing wherever an employee moves through a timetable of assignments intended to provide them with several career experiences. Task rotations are appropriate progress remedies for employees who are in search of a genera

Big data and wellbeing in the Arab world

© Springer Nature Switzerland AG 2019. All rights reserved. The rapid and widespread usage of social media platforms, such asTwitter, Facebook and Instagram has given rise to unprecedented amounts of user-generated data. This data contains expressions reflecting users thoughts, opinions and affective states. Systematic explorations of this type of data have begun to yield valuable information about a variety of psychological and cultural variables. To date however, very little of this research has been undertaken in the Arab world. It is important to extend this type of macro-level big data analysis across cultures and languages as each situation is likely to present different methodological challenges and to reveal findings particular to the sociocultural context. This chapter examines research-much of it our own-exploring subjective wellbeing in the United Arab Emirates (UAE) using data from Twitter and explores the findings from cross-linguistic analysis of happiness (positive-negative affective patterns of language use) and other variables associated with subjectivewellbeing in the region. Additionally, we explore temporal patterns of happiness observed in relation to Ramadan and other events of sociopolitical and religio-cultural significance. The UAE focus is discussed with reference to broader trends in data science, sentiment analysis and hedonometry

We tweet Arabic; I tweet English: self-concept, language and social media

© 2019 The Authors Differences in self-concept have been observed across cultures. Participants from collectivist societies tend to describe themselves using social and relational attributes (mother, student, Arab) more frequently than their individualist counterparts, who tend to rely more heavily on personal attributes (fun, tall, beautiful). Much of this past research has relied on relatively small samples of college students, tasked with spontaneously reporting self-concepts in classroom settings. The present study re-examines these ideas using data extracted from Twitter, the popular social media platform. In analysis one, the Twitter biographies of individuals exclusively posting messages in English (N = 500) and those posting only in Arabic (N = 500) were content analyzed and quantified for differences in the frequency of personal versus social attribute use. Analysis two applied a bilingual word counting algorithm to the biographies of a larger sample of Twitter users (N = 242,162), exploring the relative frequency of social attributes, specifically familial roles (e.g. mother, father, daughter, son), across both English and Arabic users. In analysis one, the Twitter biographies of exclusive Arabic users contained significantly more social attributes than their English using counterparts. In analysis two, Arabic biographies contained significantly more familial references than their English language counterparts. These findings support the idea that cultural values may influence self-construal. Big data extracted from social media platforms appear to offer a useful means of exploring self-concept across cultures and languages

Different Organization Culture

This paper discusses many important points in any different organization culture, the definition of organization culture and why we need it. Also, it focuses on  Advantage and disadvantage of cultural communication and the way of communication and applying communication theories. It discuss the problem which the employer faced in work place and who they can solve this problems. Researchers collected surveys which related to the different organization culture and dell’s culture places efficiency and competitiveness far above innovation and aesthetic. we do this surveys in many places such as: Al Fujairah Hospital, UAEU (employs and sectaries), Dubai Festival city, Tanmia for development & employer, Khat school, some company in the Abu Dhabi, UAE Red Crescent, SAAED. This paper gives as clear idea about the meaning of organization culture and how you can deal will other people who is from other countries and how can have mixture of themes characteristic by differences and similarities. Also, the kind of problems which managers faced in the firm of multiple cultures and the good way to connect with this employer

How an Innovative Climate can motivate an Entrepreneur

This is a theoretical paper of a conceptual model whose primary aim is to test, how innovative climate, Perceived Net Desirability of Self Employment (NDSE), Tolerance for Risk (TR), and Perceived Feasibility (self-efficacy) of self-employment (SE), could affect self-employment intentions.  The model also proposes how Psychological Climate Adjustment, Emotional stability, and Openness to experience, impacts perceptions of the innovative climate of organizations