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High-quality research is essential for our beloved UJPR to achieve its constitutional goal, that is, to help all peoples attain the highest possible standard of health. Research and evidence that research outcomes are critical components of improving health, our journal has always given high priority to research from developing countries. The primary importance of research for the journal has been determined to promote and conduct research in the field of health. The journal's strategy for research in health is based on the premise that health-promoting policies and practices around the world must be anchored in the best scientific knowledge. The mission of the strategy is that all partners must work together to harness science, technology and broader knowledge in order to produce research-based evidence and tools to improve global health. The journal's strategy is based on a number of key features: neutrality and independence; Global membership, unique and broad experience in public health and scientific research; Global normative role; adhere to evidence; the ability to invite scientists, researchers, scientific experts and other stakeholders to publish and benefit from the research published in the journal; The decision-making process should be guided by the principles of quality, impact and comprehensiveness of this research at the national, regional and global levels. Achieving such goals requires teamwork, and for this I appeal to all members of the journal to continuous sincere work and not leave the honorable brother, the journal editor in chief, to make the most of the effort to make the journal succeed and achieve its noble goals, as well as to deliver the journal to the prestigious position it deserves, as we all reach the delivery of the journal to Escopes in during the coming period - and I repeat here the title - a person is little by himself, much with his/her brothers/daughters

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The best thing happened to me in the last year (2018) was to be appointed as member- Editorial Board, then as an executive editor, Universal Journal of Pharmaceutical Research (UJPR) because this scientific project will assist in resolution health problems not only in developing countries but also worldwide; and I am contributed in this project under the guidance of the Editor-in-Chief and the other board members. Enduring is the key of the success accordingly congratulation to all editorial board members for their high success of today through their hard work and persistence for 3 years. The journal successfully completed 3 Yrs (Total 15 issues), 154 articles of different authors from different countries including Nigeria, Yemen, India, Cameroon, Egypt, China, Pakistan, Iran, USA, West Indies, Iraq, Malaysia and Nepal. Hence UJPR is an international journal without suspicion and indexed in more than 30 locations is other value of UJPR as an international journal. The future of the journal will be brilliant with achievement an impact factor and to be member of Scopus and ISI journals but all of that need hardworking from journal members and authors. Therefore, I will take this occasion to urge all authors to prepare their manuscripts strictly according to journal instructions so as to avoid any undue delay in its editorial processing and disappointment of rejection

PSEUDOMONAS AERUGINOSA SKIN-NASOPHARYNGEAL COLONIZATION IN THE IN-PATIENTS: PREVALENCE, RISK FACTORS AND ANTIBIOTIC RESISTANCE IN TERTIARY HOSPITALS IN SANA'A CITY -YEMEN

Objective:  Pseudomonas aeruginosa is one of most important cause of healthcare-associated infections. This active surveillance cross sectional study was aimed to determine the rate of P. aeruginosa colonization among inpatients at three tertiary hospitals in Sana'a city. In addition, to determine risk factors of colonization and the antibiotic susceptibility of the isolated P. aeruginosa.  Methods: The study included 327 inpatients. Skin and nasopharyngeal swabs were collected from all participated patients and data were collected by predesigned questionnaire. Standard methods of isolation and identification were used to isolate bacteria in pure culture then identify. Also, antibiotic sensitivity for isolated P. aeruginosa was determined by the disc diffusion method. 42 patients (12.8%) were colonized with P. aeruginosa on skin and nasopharyngeal. Results: The significant risk factors of colonization were male patients (OR=2.5), older age (OR= 2.2), burn ward (OR=37), long stay in hospital (OR=4) and burn as underlying disease (OR=45). The isolated P. aeruginosa were completely resistant (100%), to Aztroneome, Ceftriaxone, and Ciprofloxacine; and the rates of resistant were ranged between 83.3-85.7% for Amikacin, Ampicillin sulbactam Levofloxacin. Also the rates were 71.4% for Netilmicin and 92.9% for chloramphenicol. Moreover, the rates of resistant were low for Gentamicin (35.7%), Imipenem (11.9%), Pipracillin Tazobactam (11.9%), Ticaracillin calvulanic acid (31%) and Colistin sulphat (14.3%). Conclusion: In conclusion, this study has highlighted the role of hospitalization as a significant risk for P. aeruginosa colonization; concerted and coordinated efforts are required both in the hospital and community to tackle this.  These data emphasize the need to identify hospitalized patients colonized with P. aeruginosa on admission. Prediction rules or rapid diagnostic testing will help clinicians more appropriately choose empiric antibiotic therapy if subsequent infections occurred.                  Peer Review History: Received 25 November 2018;   Revised 15 December; Accepted 28 December, Available online 15 January 2019 Academic Editor:  Dr. Iman Muhammad Higazy, National Research Center, Egypt, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.5/10 Reviewer(s) detail: Dr. Omonkhelin J Owolabi, University of Benin, Nigeria, [email protected] Dr. Francis Adou Yapo, Felix Houphouet Boigny, University of Abidjan, Ivory Coast, [email protected] Similar Articles: PREVALENCE OF PSEUDOMONAS AERUGINOSA (P. AERUGINOSA) AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AT A PRIVATE HOSPITAL IN SANA'A, YEMEN IN-VITRO ANTIBACTERIAL ACTIVITY OF LACTOBACILLI METABOLITES LOADED HYDROGEL FORMULATIONS AGAINST PSEUDOMONAS AERUGINOS

THE PREVALENCE AND PHENOTYPIC CHARACTERIZATION OF EXTENDED-SPECTRUM β-LACTAMASES-PRODUCING ESCHERICHIA COLI STRAINS ISOLATES RECOVERED FROM TERTIARY HOSPITALS IN SANA'A CITY, YEMEN

Objective:  The emergence of ESBL producing Escherichia coli in clinical isolates is posing a serious threat for treating nosocomial infections. The aim of the study was to determine the frequency of extended spectrum β-lactamase (ESBL) producing Escherichia coli isolated from clinical specimens in several teaching and general hospitals in Sana'a city, Yemen, and to compare the phenotypic methods used for the characterization of ESBL producing strains. Methods: This cross sectional observational study was conducted from 1st July to 28th of August 2017, at the Department of Medical microbiology, Faculty of Medicine and Health Sciences, University of Sciences and Technology in Sana'a city, Yemen.  A total number of 3500 various clinical samples were analyzed during the study period. Escherichia coli were identified using API 20E system and ESBL detection was carried out using double-disk synergy test (DDST) and CLSI confirmatory test. Escherichia coli were isolated from 100 samples, out of which 63 (63%) were ESBL producers and 37 (37%) were non-ESBL producers. The gender distribution of ESBL producing Escherichia coli was 35/45 (77.8%) in males and 28/55 (50.9%) in females. Results: Highest frequency of ESBL producing Escherichia coli was detected in sputum (100%), wounds (83.3%) and urine (65.7%) samples. Comparison of DDST and CLSI confirmatory test showed that 65 (65%) isolates were characterized by DDST and 63 (63%) using CLSI confirmatory test. All ESBL-positive isolates were susceptible to imipenem, indicating that this agent is the best drug for treating serious infections caused by ESBL-producing E. coli.  Conclusion: In conclusion, the present study shows moderately high frequency of ESBL producing Escherichia coli among patients suffering from sepsis in tertiary hospitals in Sana'a city. DDST was found to be less efficient in ESBL detection as compared to CLSI confirmatory test.                            Peer Review History: Received 1 December 2018;   Revised 16 December; Accepted 31 December, Available online 15 January 2019 Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, [email protected]  UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected] Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, [email protected]

SERO-EPIDEMIOLOGICAL STUDY OF HEPATITIS B, C, HIV AND TREPONEMA PALLIDUM AMONG BLOOD DONORS IN HODEIDA CITY- YEMEN

Objective: Infections transmitted in blood transfusions are the most significant concern associated with blood donation. The purpose of this study was to establish the current prevalence of hepatitis viruses (B and C), HIV and T. pallidium among blood donors at National Blood Transfusion and Research Center (NBTRC) Hodeida Branch, Hodeida city, Yemen. Methods: Serological markers of HBV, HCV, HIV 1, 2, T. pallidium antibodies were studied in 25446 (males) using commercially available kits, over a period of 3 years from January 2016 to April 2018 at National Blood Transfusion and Research Center (NBTRC) Hodeida Branch , Hodeida city, Yemen. Also, the prevalence of confirmed-positive test results of these infections was evaluated among different ages. Results: The sero-prevalence of HBV, HCV, HIV, T. pallidium infections based on confirmation tests, were 0.74%, 0.19%, 0.38% and 0.18% respectively. The prevalence of HBV was significantly higher in age groups 37-46 years and 47-56 years with significant associated OR equal to 2.3 (p<0.001) and OR=2.7 (p=0.02) respectively. The prevalence of HCV was significantly higher in age groups 47-56 years with significant associated OR equal to 6.5 (p=0.003).  The prevalence of T. pallidium was significantly higher in age group 37-46 years with significant associated OR equal to 3.6 (p<0.001). Conclusion: This study highlights the prevalence of HBV, HCV, HIV, and T. pallidium among different male ages. The prevalence varies from one age group to another, being the lowest among younger and very older age groups. Therefore, extensive recruitment of young donors should help ensure a long-term increase in the blood supply without jeopardizing safety.                            Peer Review History: Received 24 April 2019;   Revised 31 April; Accepted 3 May, Available online 15 May 2019 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6/10 Average Peer review marks at publication stage: 9/10 Reviewer(s) detail: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected] Dr. Hatem Sameir Abbas, Al-Azhar University, Egypt, [email protected] Similar Articles: PREVALENCE OF HEPATITIS G VIRUS AMONG PATIENTS WITH CHRONIC LIVER DISEASE AND HEALTHY INDIVIDUALS, SANA'A CITY-YEMEN PREVALENCE AND GENOTYPING OF HEPATITIS C VIRUS IN HEMODIALYSIS PATIENTS AND EVALUATION OF HCV-CORE ANTIGEN TEST IN SCREENING PATIENTS FOR DIALYSIS IN SANA'A CITY, YEMEN EXPLOSION OF HEPATITIS B AND C VIRUSES AMONG HEMODIALYSIS PATIENTS AS A RESULT OF HEMODIALYSIS CRISIS IN YEMEN SERUM POSITIVITY OF ANA AND ASMA AMONG KHAT AND NONKHAT CHEWERS AS MARKERS FOR AUTOIMMUNE HEPATITIS TYPE 1 SERO-PREVALENCE OF HEPATITIS C VIRUS AMONG DENTAL CLINIC WORKERS IN SANA’A CITY- YEMEN AND THE RISK FACTORS CONTRIBUTING FOR ITS INFECTION PREVALENCE AND POTENTIAL RISK FACTORS OF HEPATITIS B VIRUS IN A SAMPLE OF CHILDREN IN TWO SELECTED AREAS IN YEME

CAUSES FOR EXTRACTION OF PERMANENT TEETH IN GENERAL DENTAL PRACTICES IN YEMEN

Objective: The aim of this survey was to investigate the primary causes for extraction of permanent teeth, its correlations with age and gender, as well as identify the important predictors for dental caries in Sana'a University dental clinics in Sana'a city, Yemen. Methods: The study was conducted over a period of one year; its population consisted of 1,420 patients, aged 9–72 years, who underwent tooth extraction. There were 761(53.6%) male and 659 (46.4%) female patients. The frequency distribution was calculated using the t-test, ANOVA and t test for differences in mean number of extracted teeth and the logistic regression model to evaluate the variables associated with causes for tooth extraction.Results: A total of 2,585 teeth were extracted from the 1,420 patients. The highest rate (23.1%) of extraction occurred for those 41–50 years old. Males comprised 53.6% of patients but had more teeth (1598, 61.8%) extracted than females (987, 38.2%).The rate of teeth extracted on the day of the survey per patient was 1.82±0.07 (2.1±0.1 in males and 1.5±0.05 in females). Tooth loss due to caries was 69%; periodontal disease was 28%; pre-prosthetic reasons were 1.9% and other reasons were 1.14%. There was a significant association between patient characteristics (age and gender) and number of teeth extracted in which the Mean±SD of extracted numbers were increase with increasing age and higher in male patients than in females (p<0.001). The most frequently extracted teeth were mandibular first and second molars (446, 17.3%), followed by maxillary premolars (415, 16.1%), while mandibular canines were least frequently extracted (87, 3.4%).Conclusion: In conclusion; dental caries and periodontal problems were the main causes for tooth extraction in Sana'a city, Yemen.                             Peer Review History: Received 21 March 2019;   Revised 12 April; Accepted 25 April, Available online 15 May 2019 Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, [email protected]  UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Noha El Baghdady, MTI University, Cairo, Egypt, [email protected] Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, [email protected] Similar Articles: SERO-PREVALENCE OF HEPATITIS C VIRUS AMONG DENTAL CLINIC WORKERS IN SANA’A CITY- YEMEN AND THE RISK FACTORS CONTRIBUTING FOR ITS INFECTION RISK FACTORS OF PERIODONTAL DISEASES AMONG YEMENI YOUNG DENTAL PATIENT

PREVALENCE OF MALOCCLUSION AMONG YEMENI CHILDREN OF PRIMARY SCHOOLS

Objective: Malocclusion is every difference in the arrangement of teeth beyond the standard of regular occlusion illustrated by anomalies within the dental arches. The purpose of this study was to measure prevalence of malocclusion between primary school children in Sana’a city Yemen. Methods: A cross sectional study was conducted on 1079 school children (546 girls and 533 boys), their age ranged from 7 to 12 years old from public and private schools selected randomly in Sana'a City, Yemen. The prevalence of malocclusion was investigated according to age, gender and school type based on Angle's classification. Results: The study showed that the overall prevalence of malocclusion among school children was 81.1%, in which Class I normal molar association was found only in 18.9% of school children, while Class I malocclusion included the highest percentage of the sample 70.4%, followed by Class II relation 9.5%, and Class III involved only 1.1%. The most prevalent malocclusion trait was spacing 35.7%, whereas the crowding was present in 30.0% of the sample. The deep bite was present in 10.1% followed by anterior crossbite 8.8%, midline diastema 8.6%, anterior open bite 4.5%, posterior crossbite 4.0%, and the least noted malocclusion trait was posterior open bite 0.4%. Conclusion: In conclusion, there was a high rate of malocclusion in school children and significantly increased with age, class I malocclusion was the most common followed by Class II malocclusion, while Class III was the rear. The most prevalent occlusal problem was spacing, followed by crowding.  Thus, 7-12 year-olds can benefit from interceptive and preventive oral health procedures which may either entirely prevent or reduce the development of serious types of malocclusions afterward in their lives.                         Peer Review History: Received 8 January 2020;   Revised 9 February; Accepted 1 March, Available online 15 March 2020 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.5/10 Reviewer(s) detail: Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, [email protected] Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, [email protected]   Similar Articles: COCCIDIAN INTESTINAL PARASITES AMONG CHILDREN IN AL-TORBAH CITY IN YEMEN: IN COUNTRY WITH HIGH INCIDENCE OF MALNUTRITION EVALUATION OF THE IMMUNE RESPONSE TO POLIO VACCINE IN MALNOURISHED CHILDREN IN SANA'A CITY PREVALENCE AND POTENTIAL RISK FACTORS OF HEPATITIS B VIRUS IN A SAMPLE OF CHILDREN IN TWO SELECTED AREAS IN YEME

OCCLUSAL CHARACTERISTICS OF THE PRIMARY DENTITION AMONG A SAMPLE OF YEMENI PRE-SCHOOL CHILDREN

Objective: The occlusal features change dynamically in the growing children and any disruption in the complex craniofacial growth process may lead to malocclusion, which is a major concern for the pediatric community because of its effects on dental function and beauty, as well as on the child's psyche. The aim of the present study was to study the prevalence of different occlusal traits in the primary dentition of the randomly selected pre-school children from three to five years in the city of Sana’a, Yemen. Methods: The study includes 1106 pre-school children subjected to a dental examination performed in the school premise, using the Foster and Hamilton criteria for occlusal traits. As well as inter- and intra-calibration tests were conducted for assessing the degree of agreeability. Results: Results of the study showed that the Bilateral flush terminal molar relationship was found in 60%, bilateral mesial step in 27.9%, asymmetrical relationship in 8.5% and distal step in 3.5% of tested children. The Bilateral canine class I was detected in 62.8%, asymmetrical relationship (13.6%), class II (12.5%) and class III (11.1%). Normal over-jet (OJ) of 1-3 mm was identified in 39.2%, decreased OJ <1 mm (32.7%) and edge-to-edge (8.8%). Ideal over-bite (OB) of 1-50% was detected in 64.5% and increased OB of > 50% (19.7%). Conclusion: In conclusion theBilateral flush terminal molar, class I canine relationships, normal overjet (OJ) of 1-3mm were the most commonly found sagittal occlusal traits in the current study. Ideal over-bite (OB) of 1-50% were identified in more than half of the children.                         Peer Review History: Received 2 February 2020;   Revised 21 February; Accepted 3 March, Available online 15 March 2020 Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Aya Mohammed Mohammed Essawy, MTI University- Mokattam, Egypt, [email protected] Dr. Nada Farrag, Misr International University, Egypt, [email protected] Similar Articles: COCCIDIAN INTESTINAL PARASITES AMONG CHILDREN IN AL-TORBAH CITY IN YEMEN: IN COUNTRY WITH HIGH INCIDENCE OF MALNUTRITION EVALUATION OF THE IMMUNE RESPONSE TO POLIO VACCINE IN MALNOURISHED CHILDREN IN SANA'A CITY PREVALENCE AND POTENTIAL RISK FACTORS OF HEPATITIS B VIRUS IN A SAMPLE OF CHILDREN IN TWO SELECTED AREAS IN YEME

PREVALENCE AND RISK FACTORS ASSOCIATED WITH VULVOVAGINAL CANDIDIASIS DURING PREGNANCY IN SANA'A, YEMEN

Background and objective: Women at pregnancy are further susceptible to vaginal colonization and yeast infection. The responsibility of Candida colonization in the incidence of preterm birth is correctly established. Knowing regional epidemiology and identifying risk factors of preterm birth are important for management and preventive strategies. The aim of the study was to reveal the prevalence of Candida species in vaginal swabs of pregnant women and determine odds ratio of risks for vulvovaginal candidiasis (VVC). Methods:   Pregnant women attendance routine antenatal visits in Al-Olify –family Center in Sana'a city were registered into a cross-sectional study carried out from June 2018 to March 2019. The laboratory works were carried out in the National Center of Public Laboratories (NCPHL). Samples of vaginal swabs were taken from contributors after obtaining oral consent. The classification of the Candida species was done by culture on HiCrome Candida Differential Agar at 35 °C for 48 h for making of species-specific colors. Data of demographic, clinical and risk factors were collected in a pre-designed questionnaire. Results: A total of 190 pregnant women are included. The rate of VVC was 51.6%. Candida albicans accounted for 39.5% and non-Candida albicans accounted for 12.1% of isolates, mainly C. glabrata (4.7%), C. lipolytica (3.2%), and C. famata (2.1%). When VVC risk factors were considered, there were significant risk factors with the age group 20-24 years (61%, odds ratio (OR) = 1.8), first trimester of pregnancy (61.1%, OR = 1.7), Multipara of  parity (61.8%, OR = 1.9), low socioeconomic level (60.1%, OR =2.4), and illiteracy (68%, OR = 2.2). When clinical symptoms were considered, only 86.2% of affected females had clinical signs of VVC. Conclusions: There is a high probable rate of VVC is found among pregnant women in Yemen, undiagnosed and unnoticed; and this highlights the need for health authorities to develop strategies for diagnosing VVC, including vaginal swabs for candidiasis as a routine procedure for all pregnant women. This study also revealed a steady increase in time with a non-C. albicans species  prevalence rate. VVC syndrome management guidelines in Yemen should be revised to include a special protocol for pregnant women.                                       Peer Review History: Received 14 May 2020; Revised 15 June; Accepted 1 July, Available online 15 July 2020 Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, [email protected] Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. Michael Otakhor Erhunmwunse, BTU – Cottbus, Germany, [email protected]  Dr. Mohamed Awad Mousnad,  Faculty of Pharmacy, International University of Africa (IUA), Khartoum, Sudan, [email protected]  Similar Articles: TETANUS IMMUNIZATION AMONG PREGNANT WOMEN: COVERAGE RATE AND RATE OF PROTECTION AT TIME OF DELIVERY AN EXHAUSTIVE STATISTIC ON CURRENT MUCOADHESIVE INTRAVAGINAL DRUG DELIVERY METHODOLOGIE

ORAL CANDIDA ALBICANS COLONIZATION RATE IN FIXED ORTHODONTICS PATIENTS

Objectives:  The objective of this study was to assess the oral Candida albicans colonization ( OCAC)  in a cluster of teenagers and young adults while being treated with a fixed orthodontic appliance (FOA). Subjects and methods:  The investigational group was selected from orthodontic patients whom were examined clinically as soon as to get baseline information before active treatment.  The cluster included 210 patients; 45 males, 165 females (mean age 21.6 ± 4.5 years).  Clinical, demographic data and risk factors were collected in standard questionnaire then each individual was directed to carry out oral wash by a phosphate-buffered saline solution, which was expectorated and processed intended for the isolation of Candida species on Sabouraud’s dextrose agar. The isolated Candida species were identifying by culturing on chromogenic Candida agar and notice species-specific colony natures. Results:  The predominant Candida species isolated was C. albicans with OCAC rate equal to 13.8% extensively enhanced after the insertion of a FOA, as revealed by the oral rinse (P < 0.05) techniques. The results also revealed an increase of OCAC in male patients (24.4%) than female patients (10.9%),   21-25 years patients (17.1%), and regular smoking and Qat chewing were significant associated risk factors (OR=28.6, OR=10.7 respectively , P < 0.0001).  There was no significant association between C. albicans  colonization with oral hygiene in fixed Orthodontic patients. Conclusion:  As a whole, the current data suggest that the introduction of FOA is likely to promote OCAC. Moreover, it becomes visible that the routine oral hygiene procedures performed by these patients may not necessarily reduce OCAC while smoking and chewing Qat habits significantly increased OCAC in FOA. Also smoking and Qat chewing during FOA treatment should be banned if potential harmful effects are to be prevented. Further work with a larger sample size is required to confirm or deny these results.                      Peer Review History: Received 27 March 2020; Revised 20 April; Accepted 8 May, Available online 15 May 2020 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected] Dr. Tamer Mohamed Ali El Habibi, Suez Canal University, Egypt, [email protected] Similar Articles: ORAL C. ALBICANS COLONIZATION AND NON-CANDIDA ALBICANS CANDIDA COLONIZATION AMONG UNIVERSITY STUDENTS, YEMEN PREVALENCE AND ASSOCIATED FACTORS OF ORAL NON-CANDIDA ALBICANS CANDIDA CARRIAGE IN DENTURE WEARERS IN SANA'A CITY- YEME