High-mobility group box 1, an endogenous ligand of toll-like receptors 2 and 4, induces astroglial inflammation via nuclear factor kappa B pathway

Background: Neuroinflammation has a definitive role in neurodegenerative diseases, such as Parkinson’s and Alzheimer’s disease. In addition to its pathoge- nic ligands, toll-like receptors (TLRs) can be activated by damaged endogenous molecules that induce inflammatory signalling pathways such as high-mobility group box 1 protein (HMGB1).  Materials and methods: Using an ex-vivo rat optic nerve (RON) model, we sought to determine the effects of lipopolysaccharides (LPS; TLR4 agonist), zymosan (TLR2 agonist) or HMGB1 — with or without TLR2/4 antagonists, on the expression of glial fibrillary acidic protein (GFAP) and nuclear factor kappa B (NF-ҡβ) for signalling pathway and astrocyte reactivity, using double immunohistochemistry; as well as on the modulation of the neurotoxicity. HMGB1-treated RON had significantly higher expression and co-localisation of GFAP and NF-ҡβ as compared to the un- treated control, which was a similar result to those treated with LPS and zymosan.  Results: Moreover, the HMGB1-induced inflammation was blocked by TLR2/4 antagonists (p = 0.05). However, the HMGB1-induced cell death was unblocked by TLR antagonists. Overall, HMGB1 endogenously mediates the signalling me- chanisms of neuroinflammation through TLR2/4.  Conclusions: Whereas, the neuronal death mechanism resulting from HMGB1 could be caused by a different signalling pathway. Gaining an understanding of these mechanisms may help researchers discover new therapeutic targets for neurodegenerative diseases.

Convolutional coded dual header pulse interval modulation for line of sight photonic wireless links.

The analysis and simulation for convolutional coded dual header pulse interval modulation (CC-DH-PIM) scheme using a rate ½ convolutional code with the constraint length of 3 is presented. Decoding is implemented using the Viterbi algorithm with a hard decision. Mathematical analysis for the slot error rate (SER) upper bounds is presented and results are compared with the simulated data for a number of different modulation techniques. The authors show that the coded DH-PIM outperforms the pulse position modulation (PPM) scheme and offers >4 dB code gain at the SER of 10?4 compared to the standard DH-PIM. Results presented show that the CC-DH-PIM with a higher constraint length of 7 offers a code gain of 2 dB at SER of 10?5 compared to the CC-DH-PIM with a constraint length of 3. However, in CC-DH-PIM the improvement in the error performance is achieved at the cost of reduced transmission throughput compared to the standard DH-PIM

Asthma diagnosis and treatment - 1012. The efficacy of budesonide in the treatmetn of acute asthma in children: a double-blind, randomized, controlled trial.

Background Current evidence suggests that inhaled glucocorticoids (IGC) have a more profound topical none genomic effect on bronchial airways as compared to systemic glucocorticoids. The value of adding IGC to current therapy of acute asthma is not well established. Methods We conducted a double-blind, randomized, two-arm, parallel groups, controlled clinical trial to compare the addition of budesonide 1500 mcg or placebo (normal saline) to standard acute asthma treatment (albuterol and ipratropium bromide) administered in 3 divided mixed doses within 1 hour in the emergency department (ED). Children 2-12 years of age with moderate or severe acute asthma, scoring 8-15/15 on a well-validated scoring system were included. Both groups received a single dose of prednisone 2 mg/kg/day (max. 60 mg) at the beginning of therapy. The primary outcome was admission rate within 2-4 hours from starting therapy. Results A total of 723 children were enrolled in the study over 17 months duration, of whom 139 were allowed to re-enroll and be randomized to constitute 906 randomization assignments (458 on the treatment group and 448 on the control group); with baseline mean + SD asthma score of 10.63 + 1.73; age 5.52 + 2.76 years; 35% girls; 30.8% (16.5%) with baseline severe asthma score of ≥12 (≥ 13). Statistical Analysis plan allowed for the potential dependency in response due to reenrollments of a subset of children, using Generalized Linear Mixed Modeling (GLMM) techniques. Baseline demographic and clinical characteristics were not significantly different between the two randomized groups. Seventy-five out of 458 (16.4%) of the treatment group vs. 82/448 (18.3%) of the control group were admitted, (OR 0.85, CI: 0.59-1.23, p-value=0.39). Among the severe asthmatics with baseline score ≥13, treatment vs. placebo group, GLMM adjusted admission rate was 30% vs. 47%, indicating a 17% difference in admission rate in favor of the treatment group (adjusted OR of 0.49, CI: 0.25-0.95; p-value= 0.035) that indicated a 51% reduction in the risk of admission for the treatment vs. control group. Conclusions Children with baseline severe asthma score ≥13 who were treated with budesonide had a significant reduction in their admission rate

Spectroscopic ellipsometry study of barrier width effect in self-organized InGaAs/GaAs QDs laser diodes

Molecular beam epitaxy (MBE) is used to grow InGaAs/GaAs quantum dots (QDs) laser diodes (LDs) with different barrier widths (5, 10 and 15 nm) at 580 ºC on GaAs substrates. Optical properties of the InGaAs/GaAs QDs LDs have been investigated by using the spectroscopic ellipsometry (SE) technique. A general oscillator optical model has been utilized to fit the experimental data in order to obtain the LD layer thicknesses, refractive index and absorption coefficient. The dielectric function, the energy band gap and the surface and volume energy loss functions are computed in the energy range 1-6 eV. The optical properties of the deposited InGaAs/GaAs QDs LDs are found to be affected by the barrier width, which give more insight into carriers dynamics and optical parameters in these devices. The refractive indices, the extinction coefficients and the dielectric constants of the LDs with barrier widths 15 and 10 nm are relatively larger than those of the LD with barrier width 5 nm. These indicate that optical properties of LDs with larger barrier widths (15 and 10 nm) will be improved. The interband transition energies in the three devices have calculated and identified. Two energy gaps at 1.04 and ~1.37 eV are obtained for all the heterostructures which indicates that fabricated LDs may be operating for a wavelength of 1.23 m at room temperature

Critical and Comparative Evaluation of the English Translations of the Near-Synonymous Divine Names in the Quran

Despite the fact that many problematic areas in the English translations of the Qurān have been thoroughly investigated, no substantial work has so far been devoted to critically evaluating the translation of the Divine Names, which pose paramount challenges for all translators. Critical and evaluative studies of Qurān translations seem to avoid investigating and assessing the Divine Names, which are the most sensitive and delicate Qurānic terms. This study critically and comparatively investigates how accurate and consistent are the English renderings of these Divine Names; al-Asmā al-Ḥusnā, The Most Beautiful Names (MBNs) which are recurring terms in the Qurānic text. The complexity of meanings and morphological features of these Divine Names is evidently reflected in so many cases of inaccuracy as well as inconsistency in their English translations, particularly in the renderings of the near-synonymous root-sharing Names. Translators of the Qurān have unjustifiably used different corresponding terms for the very same Divine Name when it appears on more than one occasion, and sometimes in similar Qurānic contexts. Most Qurān translators have also inaccurately used the very same English corresponding terms to translate two, if not three, near-synonymous Divine Names, whether they share the same linguistic root or otherwise. For the purpose of this evaluative study, hundreds of occurrences of the root-sharing Divine Names in five well-known English translations, namely Pickthall (1930), A. Y. Ali (1936/1986), Arberry (1955), Hilali-Khan (1985) and Abdel-Haleem (2004), have been collected, analysed and critically and comparatively evaluated. The comparative evaluation of the English renderings of the Divine Names has revealed that all the five translations not only fall short in their attempts to distinguish between the near-synonymous Names, particularly the root-sharing ones, but prove unsuccessful in rendering them accurately and consistently. The study has also revealed that the translation of Arberry shows much better quality, in terms of accuracy and consistency, in rendering the root-sharing Divine Names than other translations do. In addition to critically revealing shortcomings, inaccuracies and inconsistencies of the renderings of the Divine Names, the study suggests the use of translation technology solutions (or computer-assisted tools), such as translation memory and bilingual concordances, to improve the quality and consistency of future Qurān translations in general, and the renderings of the recurring Divine Names in particular

Botulinum toxin: Non cosmetic and off-label dermatological uses

AbstractBotulinum toxin (BT-A) is a neurotoxin which is produced by the Gram-positive anaerobic bacterium Clostridium botulinum. The efficacy of Botulinum toxin in treating hyperhidrosis and the glabellar lines is well known and FDA approved.Because BT-A inhibits the release of acetylcholine and many other neurotransmitters such as norepinephrine and substance P at the level of nerve ending, this toxin has been used to treat a lot of dermatological disorders which are thought to be triggered by these neurotransmitters.In this article we are discussing the medical off-label uses of BT-A in dermatology

Case report: breast cancer associated with contralateral tuberculosis of axillary lymph nodes

BACKGROUND: Breast cancer coexisting with tuberculous axillary lymph nodes is rare. CASE REPORT: We report a 69 years old Yemeni patient with a left breast invasive ductal carcinoma associated with contralateral tuberculous axillary lymph nodes containing microcalcifications mimicking malignancy. The patient had to be investigated for the possibility of bilateral breast cancer since she had no history of previous exposure to tuberculosis. CONCLUSION: Tuberculosis involving lymph nodes can create a diagnostic dilemma in the presence of a malignant process. The presence of calcifications in lymph nodes should raise the possibility of tuberculosis even in the absence of contact history with tuberculosis

Measuring the coupling of procedural programs

Coupling is one of two attributes of software that have great impact on software quality. Quite a few methods have been established to quantify the measurement of coupling. This paper presents a new method that provides coupling measurement of procedural programs. The first step of this method populates a description matrix that describes the software system that is being evaluated capturing all system attributes that affect coupling. Factors that affect coupling were studied and a scheme to reflect them in the description matrix was developed. A method has also been developed to calculate coupling between each two components of the system. The second step uses this method to populate a coupling matrix that indicates the coupling measurement between each two components of the system. Other metrics such as calculating the overall coupling of the system can be evaluated from the generated matrix. One of the strengths of this approach is that it can be used to measure coupling of software of the procedural languages as well as object-oriented languages. The procedures that populate the description matrix are different for the two different paradigms but everything else is the same. A comparison with three other software metrics is illustrated with the result of two experiment