6 research outputs found
Impact of weight loss on oxidative stress and inflammatory cytokines in obese type 2 diabetic patients.
Background: Type 2 diabetes mellitus is associated with abnormal
markers of inflammatory cytokines and oxidative stress markers.
Although, these abnormalities could be modulated with weight reduction;
there is limitation in clinical studies that have addressed the
beneficial effects of weight reduction in modulating biomarkers of
inflammatory cytokines and oxidative stress for obesity associated with
type 2 diabetes mellitus. Objective: This study was designed to detect
the effects of weight loss on the inflammatory cytokines, oxidative
stress markers in obese type 2 diabetic patients. Material and Methods:
Eighty obese patients with type 2 diabetes mellitus, their age ranged
from 35-57 years and their body mass index ranged from 31-35 kg/m2 were
equally assigned into 2 groups: the weight reduction group received
aerobic exercises, diet regimen, where as the control group received
medical treatment only for 12 weeks. Results: The mean values of body
mass index (BMI), tumor necrosis factor\u2013alpha (TNF-\u3b1),
interleukin-6 (IL-6), C-reactive protein (sCRP), conjugated dienes (CD)
and malondialdehyde (MDA) were significantly decreased, while the mean
values of glutathione peroxidase (GPx), superoxide dismutase (SOD) and
glutathione (GSH) were significantly increased in patients of group
(A), while changes were not significant in group (B). Also, there were
significant differences between mean levels of the investigated
parameters in group (A) and group (B) at the end of the study.
Conclusion: Weight loss ameliorates inflammatory cytokines and
oxidative stress markers in obese type 2 diabetic patients
Impact of weight reduction program on serum alanine aminotransferase activity and immunologic response in obese hepatitis B patients.
Background: Globally, chronic B viral hepatitis (HBV) is a major health
problem. Obesity is a common problem among patients with HBV. Several
studies have reported that obesity is an important risk factor that
alters immune system response in individuals with no underlying cause
of liver disease. However, there is a strong association between BMI
and the human immune system among HBV patients. Objective: This study
was to examine the correlation between body mass index, serum alanine
aminotransferase activity (ALT) and immunologic response in obese
hepatitis B patients. Material and methods: One hundred fifty male
patients with chronic hepatitis B virus, their age ranged from 30 to 45
(38.64 \ub1 7.12) years and their BMI ranged from 30-35 kg/m2. All
Subjects were included in two groups: The first group received weight
reduction program in the form of treadmill aerobic exercises in
addition to diet control whereas the second group received no
therapeutic intervention. Parameters of serum alanine aminotransferase
(ALT), CD3, CD4 and CD8 were quantified; Leukocyte, differential counts
and body mass index (BMI) were measured before and after 3 months at
the end of the study. Results: There was a 24.7%, 36.8%, 30.8%, 40.7%,
28.6%, 25.9%, 33.3% and 14.3 % reduction in mean values of alanine
aminotransferase (ALT), white blood cells, total neutrophil count,
monocytes, CD3, CD4 ,CD8 and BMI respectively in group (A) at the end
of the study. In addition, there were significant differences between
mean levels of the investigated parameters in groups. Conclusion: Based
on our findings, weight loss modulates serum alanine aminotransferase
and immune system parameters of patients with hepatitis B virus
infection
Weight loss improves biomarkers endothelial function and systemic inflammation in obese postmenopausal Saudi women.
Background: Although postmenopausal associated disorders are important
public health problems worldwide, to date limited studies evaluated the
endothelial function and systemic inflammation response to weight loss
in obese postmenopausal women. Objective: This study was done to
evaluate the endothelial function and systemic inflammation response to
weight loss in obese postmenopausal Saudi women. Material and methods:
Eighty postmenopausal obese Saudi women (mean age 52.64\ub16.13 year)
participated in two groups: Group (A) received aerobic exercise on
treadmill and diet whereas, group (B) received no intervention. Markers
of inflammation and endothelial function were measured before and after
3 months at the end of the study. Results: The values of body mass
index(BMI), interleukin-6 (IL-6), tumor necrosis factor-alpha
(TNF-\u3b1), C-reactive protein (CRP), inter-cellular adhesion
molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and
plasminogen activator inhibitor- 1 activity (PAI-1:Ac) were
significantly decreased in group (A), while changes were not
significant in group (B). Also, there were significant differences
between mean levels of the investigated parameters in group (A) and
group (B) after treatment. Conclusion: Weight loss ameliorates
inflammatory cytokines and markers of endothelial function in obese
postmenopausal Saudi women