303 research outputs found

    Management of Warfarin Anticoagulation in Patients with Fractured Neck of Femur

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    Background. Most orthopaedic units do not have a policy for reversal of anticoagulation in patients with hip fractures. The aim of this study was to examine the current practice in a district general hospital and determine difference in the time to surgery, if any, with cessation of warfarin versus cessation and treatment with vitamin K. Methods. A retrospective review of the case notes between January 2005 and December 2008 identified 1797 patients with fracture neck of femur. Fifty seven (3.2%) patients were on warfarin at the time of admission. Patients were divided into 2 groups (A and B). Group A patients (16/57; 28%) were treated with cessation of warfarin only and group B patients (41; 72%) received pharmacological therapy in addition to stopping warfarin. Time to surgery between the two groups was compared. Results. The mean INR on admission was 2.9 (range 1.7–6.5) and prior to surgery 1.4 (range 1.0–2.1). Thirty eight patients received vitamin K only and 3 patients received fresh frozen plasma and vitamin K. The average time to surgery was 4.4 days in group A and 2.4 days in group B. The difference was statistically significant (P < .01). Conclusion. Reversal of high INR is important to avoid significant delay in surgery. There is a need for a national policy for reversing warfarin anticoagulation in patients with hip fractures requiring surgery. Vitamin K is safe and effective for anticoagulation reversal in hip fracture patients

    15-02 Estimating and Enhancing Public Transit Accessibility for People with Mobility Limitations

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    This two-part study employs fine-scale performance measures and analytical techniques designed to evaluate and improve transit services for people experiencing disability. Part one puts forth a series of time-sensitive, general transit feed system (GTFS)-enhanced employment accessibility models that account for multiple transportation modes, categories of functional limitation and design characteristics of existing public transit infrastructure. Model results shed light on the degree to which a medium-size city’s public transit system addresses the gap between a theoretical continuum of rider capacities and the physical demands required to achieve mobility and access to employment. Our research finds that an individual’s combined physical mobility constraints (e.g., walking speed and maximum walking distance) and public transit infrastructure requirements (e.g., presence/absence of wheelchair boarding platforms and connections to pedestrian access routes) may reduce employment accessibility outcomes by as much as 86 percent. Part two of the study utilizes performance measures developed in part one to model—via spatially explicit structural equations—the degree to which employment accessibility explains variations in public transit ridership and work commute transportation mode share. Here we find that commute share and ridership…(results). Developing a better understanding of relationships between accessibility and transit usage, we reason, will help shed light on how American Disabilities Act (ADA) compliant transit infrastructure affects mode choice decisions among people with considerable functional limitations and across the broader population

    Economic evaluation of implementation science outcomes in low- and middle-income countries: A scoping review

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    BACKGROUND: Historically, the focus of cost-effectiveness analyses has been on the costs to operate and deliver interventions after their initial design and launch. The costs related to design and implementation of interventions have often been omitted. Ignoring these costs leads to an underestimation of the true price of interventions and biases economic analyses toward favoring new interventions. This is especially true in low- and middle-income countries (LMICs), where implementation may require substantial up-front investment. This scoping review was conducted to explore the topics, depth, and availability of scientific literature on integrating implementation science into economic evaluations of health interventions in LMICs. METHODS: We searched Web of Science and PubMed for papers published between January 1, 2010, and December 31, 2021, that included components of both implementation science and economic evaluation. Studies from LMICs were prioritized for review, but papers from high-income countries were included if their methodology/findings were relevant to LMIC settings. RESULTS: Six thousand nine hundred eighty-six studies were screened, of which 55 were included in full-text review and 23 selected for inclusion and data extraction. Most papers were theoretical, though some focused on a single disease or disease subset, including: mental health (n = 5), HIV (n = 3), tuberculosis (n = 3), and diabetes (n = 2). Manuscripts included a mix of methodology papers, empirical studies, and other (e.g., narrative) reviews. Authorship of the included literature was skewed toward high-income settings, with 22 of the 23 papers featuring first and senior authors from high-income countries. Of nine empirical studies included, no consistent implementation cost outcomes were measured, and only four could be mapped to an existing costing or implementation framework. There was also substantial heterogeneity across studies in how implementation costs were defined, and the methods used to collect them. CONCLUSION: A sparse but growing literature explores the intersection of implementation science and economic evaluation. Key needs include more research in LMICs, greater consensus on the definition of implementation costs, standardized methods to collect such costs, and identifying outcomes of greatest relevance. Addressing these gaps will result in stronger links between implementation science and economic evaluation and will create more robust and accurate estimates of intervention costs. TRIAL REGISTRATION: The protocol for this manuscript was published on the Open Science Framework. It is available at: https://osf.io/ms5fa/ (DOI: 10.17605/OSF.IO/32EPJ)

    Risk of early versus later rebleeding from dural arteriovenous fistulas with cortical venous drainage

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    BACKGROUND: Cranial dural arteriovenous fistulas with cortical venous drainage are rare lesions that can present with hemorrhage. A high rate of rebleeding in the early period following hemorrhage has been reported, but published long-term rates are much lower. No study has examined how risk of rebleeding changes over time. Our objective was to quantify the relative incidence of rebleeding in the early and later periods following hemorrhage. METHODS: Patients with dural arteriovenous fistula and cortical venous drainage presenting with hemorrhage were identified from the multinational CONDOR (Consortium for Dural Fistula Outcomes Research) database. Natural history follow-up was defined as time from hemorrhage to first treatment, rebleed, or last follow-up. Rebleeding in the first 2 weeks and first year were compared using incidence rate ratio and difference. RESULTS: Of 1077 patients, 250 met the inclusion criteria and had 95 cumulative person-years natural history follow-up. The overall annualized rebleed rate was 7.3% (95% CI, 3.2-14.5). The incidence rate of rebleeding in the first 2 weeks was 0.0011 per person-day; an early rebleed risk of 1.6% in the first 14 days (95% CI, 0.3-5.1). For the remainder of the first year, the incidence rate was 0.00015 per person-day; a rebleed rate of 5.3% (CI, 1.7-12.4) over 1 year. The incidence rate ratio was 7.3 (95% CI, 1.4-37.7; CONCLUSIONS: The risk of rebleeding of a dural arteriovenous fistula with cortical venous drainage presenting with hemorrhage is increased in the first 2 weeks justifying early treatment. However, the magnitude of this increase may be considerably lower than previously thought. Treatment within 5 days was associated with a low rate of rebleeding and appears an appropriate timeframe

    Real Time Bangladeshi Sign Language Detection using Faster R-CNN

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    Bangladeshi Sign Language (BdSL) is a commonly used medium of communication for the hearing-impaired people in Bangladesh. Developing a real time system to detect these signs from images is a great challenge. In this paper, we present a technique to detect BdSL from images that performs in real time. Our method uses Convolutional Neural Network based object detection technique to detect the presence of signs in the image region and to recognize its class. For this purpose, we adopted Faster Region-based Convolutional Network approach and developed a dataset - BdSLImset - to train our system. Previous research works in detecting BdSL generally depend on external devices while most of the other vision-based techniques do not perform efficiently in real time. Our approach, however, is free from such limitations and the experimental results demonstrate that the proposed method successfully identifies and recognizes Bangladeshi signs in real time.Comment: 6 pages, Accepted in International Conference on Innovation in Engineering and Technology (ICIET) 27-29 December, 2018, Dhaka, Banglades

    Malakoplakia in a colonic tubular adenoma: a unique case presentation

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    Malakoplakia is an unusual characteristic inflammatory condition, it is distinctive feature is the presence of histiocytic cells with eosinophilic granular cytoplasm, often known as “von Hansemann’s histiocytes”, along with the pathognomonic siderocalcific Michaelis-Gutmann bodies (MGBs). We present a case of malakoplakia within a colonic adenoma seen against a background of Enterococcus infection. To our knowledge, this is a unique presentation which has not previous been described
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