Prevalence of oral mucosal lesions in psoriatic patients: a controlled study

Objectives: This study aimed to investigate and compare the prevalence of oral mucosal lesions in a group of psoriatic patients and healthy subjects, and its correlation to multiple clinical parameters. Study design: 100 psoriatic patients and 100 closely matched controls underwent clinical oral examination. Oral lesions were diagnosed according to the criteria proposed by the World Health Organization (WHO). The patients filled the Hospital Anxiety and Depression (HAD) questionnaire and the Dermatology Life Quality Index (DLQI). The severity of psoriasis was assessed by the Psoriasis Area and Severity Index (PASI). Categorical variables were evaluated using Chi-square test or Fisher's exact test with overall significance set at p< 0.05. Results: Oral mucosal lesions were diagnosed in 43 (43%) psoriatic patients and 17 (17%) control subjects (p=0.000). Comparing psoriatic patients to control subjects the prevalence of fissured tongue (FT) was 35% vs. 13% (p=0.000); geographic tongue (GT) 17% vs. 9% (p=0.09); combination of FT and GT 5% vs. 5% (p=1.00); oral candidosis 3% vs. 0% (p=0.81); leukoedema 1% vs. 3% (p=0.62); physiologic melanin pigmentations 4% vs. 1% (p=0.37) respectively. The clinical type of psoriasis, duration of the disease, method of disease management (medicated vs. non-medicated for psoriasis), smoking habit, psychological status or the disease severity did not influence the prevalence of FT and GT. Psoriatic patients who experienced 'very large' to 'extremely large' adverse effect of psoriasis on their quality of life have significantly higher prevalence of GT (p=0.04). Conclusions: FT is significantly more common in psoriatic patients compared to controls; hence studies investigating the nature of this relationship are warranted. Oral health care providers should be aware of the predisposition of psoriatic patients to oral candidosis

Study of absorption loss effects on acoustic wave propagation in shallow water using different empirical models

Efficient underwater acoustic communication and target locating systems require detailed study of acoustic wave propagation in the sea. Many investigators have studied the absorption of acoustic waves in ocean water and formulated empirical equations such as Thorp's formula, Schulkin and Marsh model and Fisher and Simmons formula. The Fisher and Simmons formula found the effect associated with the relaxation of boric acid on absorption and provided a more detailed form of absorption coefficient which varies with frequency. However, no simulation model has made for the underwater acoustic propagation using these models. This paper reports the comparative study of acoustic wave absorption carried out by means of modeling in MATLAB. The results of simulation have been evaluated using measured data collected at Desaru beach on the eastern shore of Johor in Malaysia. The model has been used to determine sound absorption for given values of depth (D), salinity (S), temperature (T), pH, and acoustic wave transmitter frequency (f). From the results a suitable range, depth and frequency can be found to obtain best propagation link with low absorption loss

Topical vitamin A treatment of recalcitrant common warts

<p>Abstract</p> <p>Background</p> <p>Common warts (<it>verruca vulgaris</it>) are benign epithelial proliferations associated with human papillomavirus (HPV) infection. Salicylic acid and cryotherapy are the most frequent treatments for common warts, but can be painful and cause scarring, and have high failure and recrudescence rates. Topical vitamin A has been shown to be a successful treatment of common warts in prior informal studies.</p> <p>Case</p> <p>The subject is a healthy, physically-active 30 old female with a 9 year history of common warts on the back of the right hand. The warts resisted treatment with salicylic acid, apple cider vinegar and an over-the-counter blend of essential oils marketed for the treatment of warts. Daily topical application of natural vitamin A derived from fish liver oil (25,000 IU) led to replacement of all the warts with normal skin. Most of the smaller warts had been replaced by 70 days. A large wart on the middle knuckle required 6 months of vitamin A treatment to resolve completely.</p> <p>Conclusion</p> <p>Retinoids should be further investigated in controlled studies to determine their effectiveness in treating common warts and the broad range of other benign and cancerous lesions induced by HPVs.</p

An Integrated Approach to Water-Energy Nexus in Shale-Gas Production

Shale gas production is associated with significant usage of fresh water and discharge of wastewater. Consequently, there is a necessity to create proper management strategies for water resources in shale gas production and to integrate conventional energy sources (e.g., shale gas) with renewables (e.g., solar energy). The objective of this study is to develop a design framework for integrating water and energy systems including multiple energy sources, the cogeneration process and desalination technologies in treating wastewater and providing fresh water for shale gas production. Solar energy is included to provide thermal power directly to a multi-effect distillation plant (MED) exclusively (to be more feasible economically) or indirect supply through a thermal energy storage system. Thus, MED is driven by direct or indirect solar energy and excess or direct cogeneration process heat. The proposed thermal energy storage along with the fossil fuel boiler will allow for the dual-purpose system to operate at steady-state by managing the dynamic variability of solar energy. Additionally, electric production is considered to supply a reverse osmosis plant (RO) without connecting to the local electric grid. A multi-period mixed integer nonlinear program (MINLP) is developed and applied to discretize the operation period to track the diurnal fluctuations of solar energy. The solution of the optimization program determines the optimal mix of solar energy, thermal storage and fossil fuel to attain the maximum annual profit of the entire system. A case study is solved for water treatment and energy management for Eagle Ford Basin in Texas

A Stochastic Optimization Approach to the Design of Shale Gas/Oil Wastewater Treatment Systems with Multiple Energy Sources under Uncertainty

The production of shale gas and oil is associated with the generation of substantial amounts of wastewater. With the growing emphasis on sustainable development, the energy sector has been intensifying efforts to manage water resources while diversifying the energy portfolio used in treating wastewater to include fossil and renewable energy. The nexus of water and energy introduces complexity in the optimization of the water management systems. Furthermore, the uncertainty in the data for energy (e.g., solar intensity) and cost (e.g., price fluctuation) introduce additional complexities. The objective of this work is to develop a novel framework for the optimizing wastewater treatment and water-management systems in shale gas production while incorporating fossil and solar energy and accounting for uncertainties. Solar energy is utilized via collection, recovery, storage, and dispatch of heat. Heat integration with an adjacent industrial facility is considered. Additionally, electric power production is intended to supply a reverse osmosis (RO) plant and the local electric grid. The optimization problem is formulated as a multi-scenario mixed integer non-linear programming (MINLP) problem that is a deterministic equivalent of a two-stage stochastic programming model for handling uncertainty in operational conditions through a finite set of scenarios. The results show the capability of the system to address water-energy nexus problems in shale gas production based on the system&rsquo;s economic and environmental merits. A case study for Eagle Ford Basin in Texas is solved by enabling effective water treatment and energy management strategies to attain the maximum annual profit of the entire system while achieving minimum environmental impact

Homozygosity Mapping Places the Acrodermatitis Enteropathica Gene on Chromosomal Region 8q24.3

Acrodermatitis enteropathica (AE) is a rare autosomal recessive pediatric disease characterized by dermatitis, diarrhea, alopecia, and growth failure. The disease results from insufficient uptake of zinc by the intestine and can be fatal unless the diet is supplemented with zinc. To map the gene responsible for AE, a genomewide screen was performed on 17 individuals, including 4 affected individuals, in a consanguineous Jordanian family. Three markers—D8S373, D10S212, and D6S1021—had a pattern consistent with tight linkage to a recessive disease: one allele in the affected sibs and multiple alleles in unaffected sibs and parents. Two-point parametric linkage analysis using FASTLINK identified one region, D8S373, with a maximum LOD score >1.5 (1.94 at D8S373: recombination fraction .001). Twelve additional markers flanking D8S373 were used to genotype the extended family, to fine-map the AE gene. All five affected individuals—including one who was not genotyped in the genomewide screen—were found to be homozygous for a common haplotype, spanning ∼3.5 cM, defined by markers D8S1713 and D8S2334 on chromosomal region 8q24.3. To support these mapping data, seven consanguineous Egyptian families with eight patients with AE were genotyped using these markers, and six patients from five families were found to be homozygous in this region. Multipoint analysis with all consanguineous families, by Mapmaker/Homoz, resulted in a maximum LOD score of 3.89 between D8S1713 and D8S373. Sliding three-point analysis resulted in a maximum LOD score of 5.16 between markers D8S1727 and D8S1744