Weighted αβ-equistatistical Convergence for Double Sequences of Functions of Two Variables

Karakaya and T.A. Chiristi extended the definition of statistical convergence to weighted statistical convergence in [37], using the sequence of real numbers , satisfying some conditions. The modification of this topic was fulfilled in some papers such as [21] and [30]. It is well known that if , for all k, the weighted statistical convergence reduces to statistical convergence. Karakaya and Karasia [38] defined weighted -statistical convergence of order , which does not have this property. In this extension for the case , for all k, weighted -statistical convergence of order does not reduce to -statistical convergence. Later Aktuğlu and Halil introduced a modification in [12] to remove this extension problem. In this paper we introduce weighted -equistatistical convergence of order  for  double sequences, by using two real sequences   and , considering the modified extension with improved method, also we use this definition to prove Korovkin type approximation theorem via weighted  -equistatistical convergence of order  and weighted -statistical uniform convergence of order  for bivariate functions on . Some examples of positive linear operators are constructed to show that, our approximation results work, but its uniform case does not work. Furthermore rate of weighted -equistatistical convergence of order  are studied

On the Solvability of Caputo -Fractional Boundary Value Problem Involving -Laplacian Operator

We consider the model of a Caputo -fractional boundary value problem involving -Laplacian operator. By using the Banach contraction mapping principle, we prove that, under some conditions, the suggested model of the Caputo -fractional boundary value problem involving -Laplacian operator has a unique solution for both cases of and . It is interesting that in both cases solvability conditions obtained here depend on , , and the order of the Caputo -fractional differential equation. Finally, we illustrate our results with some examples

Turkish Clinicians Opinions About COVID Treatment in 2nd and 3rd Level Hospitals What Did Change from 2021 to 2022? Results of 2 Years of Follow-up

Objective:To determine the change in opinion about the treatment options of Turkish doctors who fight Coronavirus (COVID) in 2nd and 3rd level hospitals.Method:A questionnary compromised of 14 questions is asked to clinicians who worked in COVID clinics of 2nd and 3rd level hospitals in March 2021 and March 2022.Results:Prednisolone, IV use of 60 and 80 mg when added to standart therapies was observed more effective in 2022 than in 2021. Also, use of high doses of prednisolone (250 mg and higher) was also found more efective in 2022 than 2021. Acetyl salicilic acide (ASA) is used in routine treatment in both years, but there was a small decline of trust level in its effectiveness in 2022 than in 2021. Low molecular weight heparine, (especially enoxaparine) is also used in the treatment of COVID for both years and a relatively small decline of trust in its effectiveness was observed in 2022 than in 2021. For vaccines, use of BIONTECH was the golden choice of clinicians for themselves and to be used for their relatives.Conclusion:During the pandemic, clinicians tried to find the right treatment option to gain control over COVID, at the end ofalmost 3 years, it is well understood that there was no specific treatment but vaccines, steroids, ASA, low molecular weight heparin were the best agents to be used to help COVID patients not to decline to more severe conditions. In Turkey, after our study we can conclude that Turkish clinicians used the similar treatment options and vaccines as their global colleagues and found those agents effective than the other options

TÜKETİCİLER MARKALARI NASIL TERCİH EDİYOR? Kamu Sektörü Çalışanlarının Giysi Markalarını Tercihini Etkileyen Faktörlere Yönelik Bir Araştırma

Günümüzde işletmelerin yoğun rekabet ortamında rakiplerinden farklılaşmasıve tüketicinin zihninde yer almasımarkalaşma ile mümkün olmaktadır. Marka, tüketicilerin ilgisini çekmek ve satın almaya teşvik etmek için en önemli faktördür. Tüketicilerin satın alma davranışlarıürünün/hizmetin özelliklerinin yanında hedef kitlenin demografik, psikolojik, sosyolojik vb. özellikleri tarafından da etkilenmektedir. Tüketicilerin birçok marka arasından birini tercih etmesi işletmenin hedef kitlesinin özelliklerini belirlemesi ve buna uygun olarak stratejiler geliştirmesine bağlıdır. Hedef kitlesine mesajınıdoğru bir şekilde iletmesi yoluyla marka imajıgeliştirmek ve markaya bağlılık yaratmak işletmelerin temel amacıhaline gelmiştir. Bu çalışmada, kamu sektöründe çalışan tüketicilerin giysi satın alma davranışlarında marka tercihleri ve bunlarıetkileyen faktörler değerlendirilmektedir

Evaluation of Open and Green Space Systems in the Context of Urban Livability

Urban that has overgrown in recent years have affected human lifestyle and ecological balance in a negative way. Open and green spaces decreased. With this, unhealthy urban conditions occur. Therefore, urban is becoming more unlivable. The aim of this study, starting from the problem of insufficient/unqualified open and green areas in urban, is to show that cities are more livable when the open and green spaces system is designed. The “top 10 livable cities” ranking the world cities are listed by 6 different institutions and the same cities included in this list are selected. The open and green areas of 4 different selected cities were examined. In the scope, two basic concepts are based on: open-green space systems and urban livability. As a result of the study, it has been seen that open and green space systems affect cities more livable. Therefore, open and green areas are planned systematically for maximum benefit with a sustainable approach. However, systems also need new approaches at some points. At this point, a hypothetical open green space system is proposed in this study. The concept of urban liveability and open and green spaces, an index of urban liveability, are explained. Then, open and green space systems in the literature are clarified with examples. To show the relationship between urban liveability and open green spaces, the research results done by different institutions, the most overlapping cities have been selected according to the top 10 list of most liveable cities list. The value of this study to make itself original and the literature contribution is that at the end of the research, a new open and green system was suggested based on the open and green systems in the literature

Ziyaretçi Deneyimi ve Sanal Müzeler: Müzelerin Web Sitelerine Yönelik Bir Analiz

Kültürel mirasın aktarılmasında önemli rol oynayan müzeler, dijitalleşmeyle birlikte gerçek ortamın yanı sıra çevrimiçi ortamlarda da faaliyet göstermektedir. Özellikle deneyimsel pazarlama alanındaki çalışmalar dikkate alındığında çevrimiçi ortamda bulunan ve sanal müze olarak tanımlanan web sitelerinin, müze ziyaretçi deneyimi unsurlarına etki eden tasarım faktörleri bağlamında değerlendirilmesi bu çalışmanın ana temasını oluşturmaktadır. Tanımlayıcı (betimleyici) araştırma modeli ile gerçekleştirilen çalışmada, dijitalleşmenin etkisinde dönüşüm geçiren müzelerin web sitelerinde karşımıza çıkan sanal müze olgusu ve kullanıcı/ziyaretçi deneyimi kavramlarına yönelik literatür taraması aktarıldıktan sonra, deneyime yönelik boyutlar ve kullanıcı memnuniyeti yüksek internet sitesi tasarım unsurlarına yönelik boyutlar karşılaştırmalı bir içerik analizi ile incelenmiştir. Analize tabi tutulan sanal müzeler web sitesi analizinde deneyimli beş araştırmacı tarafından; etkileşimlilik, uyarlama/kişiselleştirme, sanal müze tasarım unsurları ve estetiği, güvenlik ve kişisel gizlilik ile bilgi, eğitim ve eğlence unsurlarının sunumu olmak üzere beş ana kategoride değerlendirilmiştir. Amaçlı örneklem yöntemi kullanılan araştırmada Türkiye’den ve dünyadan kamuya açık olarak faaliyet gösteren sanal müze web siteleri ele alınmıştır

İdrar Örneklerinde L-2-Hidroksiglutarik Asitin Kapiler Elektroforez-İndirekt UV Dedeksiyon ile Hızlı Tayini

Aim: L-2-hydroxyglutaric aciduria (L2HGA) which is autosomal recessive and characterized by psychomotor retardation, cerebellarataxia, variable macrocephaly, and epilepsy is a rarely seen neurometabolic disease. The disease is biochemically identified by slightlyincreased L-2HGA levels in urine, cerebrospinal fluid, and plasma.Materials and Methods: A sensitive and rapid capillary electrophoretic technique was used for the determination of L2HGA in urine.Since the L2HGA lacks of chromophore, an indirect UV detection method was applied.Results: The running electrolyte consisted of 10 mmol/L 2,6-pyridinedicarboxylic acid (PDC) at pH 5.6 containing 0.1 mmol/L ofcetyltrimethylammonium bromide (CTAB). PDC was chosen because of its good chromophoric property for indirect UV detection. CTABwas used as electro-osmotic flow (EOF) reversal. The method was well-validated in the selected conditions. The detection limit of themethod L2HGA was 1.16 ?mol/L. The migration time of L2HGA was less than 2.0 min.Conclusion: The developed method was applied to the urine samples collected from 16 patients who suffer from L-2-hydroxyglutaricaciduria and 4 healthy volunteers.Amaç: L-2 hidroksiglutarik asidüri (L2HGA) otozomal resesif geçişli, psikomotor gerilik, serebellar ataksi ve değişken makrosefali veya epilepsi ile karakterize edilen nadir görülen nörömetabolik bir hastalıktır. Hastalık biyokimyasal olarak idrarda, beyin omurilik sıvısında ve çok az miktarda plazmada artmış L-2HGA seviyeleri ile tanımlanır. Materyal ve Metot: Bu çalışmada, idrarda L-2-hidroksiglutarik asitin tayini için hızlı ve hassas bir kapiler elektroforez yöntemi geliştirilmiştir. L-2-hidroksiglutarik asit kromofor gruba sahip olmadığı için, indirekt UV deteksiyon metodu uygulanmıştır. Bulgular: Çalışma tamponu pH 5.6’da 0.1 mmol/L setiltrimetilamonyum bromür (CTAB) içeren 10 mmol/L 2,6-piridindikarboksilik asitten (PDC) oluşmaktadır. PDC iyi bir kromoforik özellik göstermesinden dolayı indirekt deteksiyon için uygundur. CTAB elektro-osmotik akışı (EOF) ters çevirmek için kullanılmıştır. L-2-hidroksiglutarik asit için tayin limiti 1.16 ?mol/L’dir. Geliş zamanı ise 2.0 dakikadan daha az bir süredir. Sonuç: Geliştirilen metod 16 L-2-hidroksiglutarik asidüri hastasından ve 4 sağlıklı gönüllüden toplanan idrar örneklerine uygulanmıştır

Determination of Environmental Ethics Approaches of Urban and Regional Planning Students

Urban planners who are environmentally conscious and aware will take action to take responsibility, inform, and control. Raising environmental awareness is essential in urban planning education to understand environmental problems. Therefore, it is necessary to educate urban planning students on environmental ethics. This study investigates the environmental attitudes and behaviors of urban and regional planning students, who will shape the environment in the future within the context of the value-belief-norm theory. Moreover, to find clues that will shape environmental education in the course curriculum. The study included 226 students from the Department of Urban and Regional Planning in the Faculty of Architecture of Yıldız Technical University (YTU) and Amasya University (AU). Questionnaire data has been evaluated using principal components analysis, correlation analysis, T-test, and ANOVA analysis. According to the study findings, urban planning students have adopted biocentric, ecocentric, and anthropocentric value orientations. The study has found that students with ecocentric value orientation tend to show more pro-environmental behavior. The study concludes that the student’s characteristics also affect how they show pro-environmental behavior and evaluate environmental policies. In conclusion, focusing on ecocentric approaches in urban planning education can positively affect adopting pro-environmental behavior and policies. Additionally, study findings show that students with relatively better economic conditions are more inclined to have a biocentric value orientation. Based on the literature and these study findings, pro-environmental behavior is not a single-dimensional structure caused only by individuals' personal and professional characteristics. People's environmental attitudes and behaviors are shaped by their upbringing, school, friends, and culture. It shows that pro-environmental behavior has a multi-dimensional complex structure, and a conceptual framework can provide guidance to explain these kinds of behavior

Rapid Determination Of Orotic Acid Level in Urine By Capillary Electrophoresis Coupled with Contactless Conductivity Detection

İdrarda orotik asidin aşırı atılımı üre döngüsü bozukluğu ve pirimidin sentez bozukluğu gibi doğumsal metabolik hastalıklarda görülür. Bu nedenle orotik asidin hızlı bir şekilde tayini hayati öneme sahiptir. Bu çalışmada idrar örneklerinde orotik asidin kantitatif düzeylerinin belirlenmesi için yeni, basit, ucuz ve hızlı bir kapiler elektroforetik analiz yöntemi geliştirildi. Orotik asidin temassız iletkenlik dedektörü (C4D) kullanılarak kapiler elektroforez yöntemi ile ayrımı için pH’ı 6,5 olan 20 mM 4-Morfolinetansülfonik asit (MES), 10 mM Histidin ve 0,1 mM setil trimetilamonyum bromür (CTAB) içeren bir ça-lışma tamponu ile geliştirildi. Orotik asidin ayrılması yaklaşık 3,5 dakika gibi kısa bir sürede tamamlandı. Göç zamanlarının ve düzeltilmiş pik alanlarının tekrarlanabilirliği sırasıyla %RSD olarak 1,25 ve 4,31 olarak bulundu. En düşük dedeksiyon limiti (LOD) 0,733 mg / L ve en düşük tayin limiti de (LOQ) 2,443 mg / L olarak bulundu. Metodun idrarda orotik asit düzeylerinin tayin edilmesinde kolaylıkla ve hassasiyetle kullanılabileceği gösterildi.Excessive excretion of orotic acid in urine arises as a result of some inborn metabolic diseases such as urea cycle disorders and pyrimidine synthesis disorders. Therefore, rapid determination of orotic acid in the neonatal period is vital. Existing methods for measuring orotic acid levels in urine are both time consuming and expensive. Consequently, rapid definition of the orotic acid level in human urine is important. In this current study a novel, simple, cost effective and rapid (fast) capillary electrophoretic analysis method was developed for quantitative measurement of orotic acid content in urine samples. Determination of orotic acid by employing capillary electrophoresis coupled with contactless conductivity detection was achieved by using, 20 mM 4-Morpholineethanesulfonic acid (MES), 10 mM Histidine, 0.1 mM Cetyltrimethylammonium Bromide (CTAB) at pH of 6.5 as optimum electrolyte solution. Orotic acid was well separated from the sample constituents within a short analysis time less than 3.5 minutes. The precisions for the migration times and corrected peak areas were calculated as 1.25 and 4.31 RSD% respectively. Limit of detection and limit of quantification of the proposed method were also calculated as 0.733 mg / L and 2.443 mg / L respectively. The developed sensitive and facile capillary electrophoresis method was validated and applicability of the method was successfully demonstrated by assessment of orotic acid content in urine

Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency

PURPOSE: Multiple acyl-CoA dehydrogenase deficiency (MADD) is a life-threatening, ultrarare inborn error of metabolism. Case reports described successful D,L-3-hydroxybutyrate (D,L-3-HB) treatment in severely affected MADD patients, but systematic data on efficacy and safety is lacking.METHODS: A systematic literature review and an international, retrospective cohort study on clinical presentation, D,L-3-HB treatment method, and outcome in MADD(-like) patients.RESULTS: Our study summarizes 23 MADD(-like) patients, including 14 new cases. Median age at clinical onset was two months (interquartile range [IQR]: 8 months). Median age at starting D,L-3-HB was seven months (IQR: 4.5 years). D,L-3-HB doses ranged between 100 and 2600 mg/kg/day. Clinical improvement was reported in 16 patients (70%) for cardiomyopathy, leukodystrophy, liver symptoms, muscle symptoms, and/or respiratory failure. D,L-3-HB appeared not effective for neuropathy. Survival appeared longer upon D,L-3-HB compared with historical controls. Median time until first clinical improvement was one month, and ranged up to six months. Reported side effects included abdominal pain, constipation, dehydration, diarrhea, and vomiting/nausea. Median D,L-3-HB treatment duration was two years (IQR: 6 years). D,L-3-HB treatment was discontinued in 12 patients (52%).CONCLUSION: The strength of the current study is the international pooling of data demonstrating that D,L-3-HB treatment can be effective and safe in MADD(-like) patients.</p