Operations-Based Knowledge Management

This paper is about knowledge management (KM) in Aircraft Engineering (AE). This industry is highly technology dependant; thus, enhanced KM in AE is a key success factor. This paper analyses KM literature, and offers insights into the existing KM practices in AE using a case study in the Saudi Arabian Aviation industry (SAAI). The KM practices were ascertained by interviewing senior aircraft engineers as well as through observations during one of the author's 6-year employment as aircraft engineer in the SAAI. Synthesis of these results with the KM literature identified gaps between the KM theory and current practices in AE. Finally, an operations-based knowledge management (OBKM) system framework was developed to address these gaps and overcome ineffectiveness in current practices

Managing Knowledge in Aircraft Engineering

In this paper, the authors analyse knowledge management (KM) practices in civil aviation industry and introduce a framework for better management of knowledge in aircraft engineering (AE). After comprehensive review of KM literature, this paper offers insights into the existing KM practices in AE using a case study in the Saudi Arabian Aviation industry (SAAI). The KM research data was collected through discussions and interviews as well as through observations during one of the authorâs employment as aircraft engineer in the SAAI. Synthesis of these results with the KM literature was used to identify the gaps between the KM theory and current practices in AE. Finally, an operationsbased knowledge management (OBKM) system framework was developed to address these gaps and overcome ineffectiveness in current practices

How Can Every Organization Manage the Operational Risk?

This article describe how every organization (generally) and Australian Organizations (specifically) can manage the operational risks. Recently, the operational risks are the significant issues in every organization because every organization will suffer from poor operational performance due to risks, failure, and problems such as a number of losses which are likely to be made worse. Basically, the operational risk management process has five steps, identification, analysis, treatment, controlling, and communication/consulting. Generally, many organizations (in particularly in Australia and New Zealand) have already used AS/NZS 4360-Risk Management System, AS/NZS 4801-Occupational Health and Safety Management System, ISO 14001: Effective Environmental Management System, ISO 9001: Quality Management System, AS/NZS 7799: Information Security Management, AS/NZS 3806: Compliance Management System for reducing/mitigating/managing the operational risks. Based on the SAI Certification Register, the number of Australian Organizations got the AS/NZS ISO 9000 series, AS/NZS 14000 series, AS/NZS 4801 and AS/NZS 7799.2:2000 Certifications are 3338, 30, 20 and 5 respectively. It can conclude that Australian Organizations prefer used AS/NZS ISO 9000 series rather than AS/NZS ISO 14000 series, AS/NZS 4801 and AS/NZS 7799.2:2000

Analysis of Advantages and Disadvantages of Current Operational Risk Management Models (AS/NZS 4360, AS/NZS ISO 9000, AS/NZS ISO 14000, AS/NZS 4801, AS/NZS 3806, AS/NZS 4444)

This paper will describe about the analysis of advantages and disadvantages of current operational risk management models (AS/NZS 4360: Risk Management, AS/NZS 4801: Occupational Health and Safety Management Systems, AS/NZS ISO 9001: Quality Management System, AS/NZS ISO 14001: Environment Management System, AS/NZS 3806: Compliance Management System, AS/NZS 4444: Information Security Management) based on expert experiences and extracting the literature review. The advantages of most current models are widely adopted by industries of various of sizes as the basis for their operational risk management. In addition, they may help the organizations to improve the operations and competitiveness. However, there are some disadvantages of most current models such as the models are very general (guidance only), not specific to cover particular risks of industries. And they don\u27t have the specific tools and processes. In addition, they may not be able to integrate all elements of the management systems such as safety, health, environment, quality, security, and compliance

REMOVAL OF PHENOL USING POLYMER COATED MAGNETIC NANOPARTICULAR ACTIVATED CARBON

Copyright © 2021 The Author(s). Phenol is a toxic organic pollutant which is present in many industrial effluent streams originating from petrochemical industry, ceramic production process, wood plants and resin manufacturing plants. Phenol is difficult to remove from most wastewater effluent streams. In the presented study, phenol removal from wastewater sample was investigated using the adsorption method. The experiments were conducted to investigate the adsorption performance of activated carbon (AC), magnetic activated carbon (MagAC), styrenebutadiene styrene magnetic activated carbon (SBS/MagAC) and poly charbonat magnetic activated carbon (PC/MagAC) samples. The effects of various parameters, for example, temperature, solid-liquid ratio, adsorbent type, initial phenol concentrations and solution pH were investigated under similar experimental conditions. The results showed that the maximum adsorption of 98-99% was achieved at low pH values with the use of both AC and MagAC adsorbent materials. It was also found that the polymer coated magnetic materials did not perform very well at high pH values. The experimental data also showed that MagAC and SBS/MagAC were more effective than AC and PC/MagAC to remove phenol. In conclusion, we found that phenol can be removed more easily from the aqueous medium by using both magnetic and polymeric materials.Muğla Sıtkı Koçman Üniversity, Research Project Coordination Unit, project (19/081/01/1/1)

Targeted intraoperative radiotherapy tumour bed boost during breast conserving surgery after neoadjuvant chemotherapy in HER2 positive and triple negative breast cancer

Introduction: Targeted intraoperative radiotherapy (TARGIT - IORT) as a tumour bed boost after breast conserving surgery is well established for women with early breast cancer. A previous study from our group shows a beneficial effect of TARGIT-IORT on overall survival (OS) but not diseasefree survival (DFS) after neoadjuvant chemotherapy compared to an external boost suggesting a potential non-inferiority of TARGIT-IORT. In this study, we present results regarding the high-risk subset of patients (i.e. with triple negative (TN) and HER2 positive tumours) from this cohort. Method: In this non-randomized cohort study involving patients with HER2 positive (n= 28) and triple negative (n=42) tumours after NACT we compared outcomes of 40 patients with tumour bed boost applied with TARGIT IORT during lumpectomy versus 30 patients treated in the previous 13 months with external (EBRT) boost. All patients received whole breast radiotherapy. Rates of DFS and OS were compared. Results: Median follow up was 49 months. In comparison of TARGIT-IORT vs. EBRT 5-year Kaplan- Meier estimates of OS showed no significant difference among patients with HER2 positive tumours (100% vs. 91.7%, log rank p = 0.22). The same was seen for DFS (83.3% vs. 77.0%, log rank p=0.38). The results for TN cases were similar (OS : 87.5% vs. 74.1%, log rank p=0.488; DFS 87.5% vs. 60%, log rank p=0.22). Conclusion: Although survival estimates trended towards favouring TARGIT-IORT, no significant differences could be observed and the significantly positive result for OS favoring TARGIT-IORT in the whole cohort of 116 patients could not be reproduced in this subset analysis of patients with TN and HER2 positive tumours. This may be contributable to the limited number of patients but may also indicate that effects seen in the whole cohort were mainly driven by ER and/or PR positive and HER2 negative tumours. Most importantly, non-inferiority of TARGIT-IORT as an intraoperative boost could be reproduced in these high-risk patients

Interactions between polymeric nanoparticles and different buffers as investigated by zeta potential measurements and molecular dynamics simulations

Zeta potential is an essential surface parameter in the characterization of nanoparticles, determined at the interface of loosely bound ions (diffuse layer) at the nanoparticle surface and free ions in solution. The ionic concentration and pH of the solution are known to, by definition, influence the composition of the diffuse layer and zeta potential accordingly. Thus, to fix the solution's pH for valid zeta potential measurements, buffers are frequently used. However, an issue that remains largely neglected is that buffers could also additionally alter the electrokinetic properties of nanoparticles through specific molecular interactions. Therefore, a thorough molecular understanding of buffer-nanoparticle interactions is needed to correctly implement zeta potential results. Thus, in order to study nanoparticle-buffer interactions, we first adopted a simple experimental approach of measuring zeta potential of common polymeric nanoparticle systems at different buffer concentrations, pH, and nanoparticle-buffer fraction ratios. We observed that zwitterionic/cationic buffer molecules impart significant interference to the electrokinetic properties of structurally diverse polymer nanoparticles, by causing zeta potential suppression or even inversion during the experiments. In parallel, advancement in computation resources nowadays allow studying intermolecular interactions of nanoparticles and other complex molecules by molecular dynamics (MD) simulations. Thus, by performing MD simulations for six different polymeric nanomaterials with commonly used buffer molecules, we found that noncovalent interactions play a significant role in altering the observed zeta potential values, which may contribute to erroneous results and false particle characterizations if not taken properly into account in zeta potential measurements.</p

Rapidly progressive glomerulonephritis in a child with Henoch-Schönlein Vasculitis and familial Mediterranean fever

Henoch-Schonlein Vasculitis (HSV) is systemic small vessel vasculitis involving the skin, kidney, joints, and gastrointestinal tract. The proportion of patients reported to have renal involvement varies between 20% and 80%. Rapidly progressive glomerulonephritis (RPGN)is rare syndrome in children, characterized by clinical features of glomerulonephritis (GN) and rapid loss of renal function. We present a severe kidney involvement in a 14 year old boy with HSV in who is carring MEFV mutation. A 14 year old boy had developed sudden onset of palpable purpuric rash on his extensor surfaces of lower extremities. He had elevated an erythrocyte sedimentation rate (ESR) (45 mm/h), C-reactive protein (3.74 mg/dl), serum urea 66 mg/dl, serum creatinine 1.8 mg/dl. Also, he had hypocomplementemia. Antinuclear antibody, anti ds DNA, antineutrophil cytoplasmic antibody, anticardiolipine antibodies were negative. Urinalysis revealed macroscopic hematuria and proteinuria with a 24-h urinary protein excretion of 55 mg/m2/h. The renal biopsy specimen showed crescentic and necrotizing glomerulonephritis. He had also M694V/E148Q compound heterozygote mutation. Clinical symptoms and renal failure resolved with intermittant hemodialysis and medical therapy