4-(Methyl­amino)benzoic acid

The asymmetric unit of the title compound, C8H9NO2, contains three crystallographically independent mol­ecules, which are essentially planar, the carboxyl O atoms deviating by 0.091 (3), 0.101 (2) and 0.164 (3) Å from the mean plane through the non-H atoms. In the crystal, all three mol­ecules form O—H⋯O hydrogen-bonded about inversion centers, forming eight-membered rings with graph-set notation R 2 2(8). In addition, N—H⋯O hydrogen bonding and C—H⋯π inter­actions reinforce the packing

The impact of concurrent pelvic organ prolapse reconstructive surgery on midurethral sling procedure outcome

 Objectives: To evaluate the effect of concurrent pelvic organ prolapse (POP) reconstructive surgery on midurethral sling (MUS) procedure outcome. Material and methods: The present retrospective study included 300 women with urodynamically diagnosed stress urinary incontinence that underwent MUS procedures with or without concurrent POP reconstructive surgery. Patients were divided into four groups according to the performed surgery; 1) transobturator tape (TOT), 2) TOT with POP surgery (anterior colporrhaphy, posterior colporrhaphy and vaginal hysterectomy), 3) tension free vaginal tape (TVT), 4) TVT with POP surgery. Outcomes of surgeries for each group were evaluated postoperatively at the end of the first and sixth month by performing a cough stress test and also using the Incontinence Impact Questionnaire-7 (IIQ-7) and Urogenital Distress Inventory (UDI-6) questionnaires. Presence of a negative cough stress test was defined as “Cure”. Multivariate regression was used to identify the parameters for surgical failure. Results: Forty-two, 70, 49 and 139 women underwent isolated TOT, concurrent TOT and POP, isolated TVT and concurrent TVT and POP surgery, respectively. Postoperative UDI-6 score and postoperative cure rate were significantly higher in the only TOT group as compared to the TOT + POP group. However, in multiple regression analysis, women’s age, parity, body mass index, menopausal status, preoperative urodynamic parameters, MUS types and presence of any concomitant POP reconstructive surgery were found to have no significant effect on surgical outcome. Conclusions: Concurrent POP reconstructive surgery including anterior colporrhaphy, posterior colporrhaphy and vaginal hysterectomy have no affect MUS procedure outcomes

Prenatal olarak tanı konulan parsiyel monozomi 13q sendromu olgusu

13. kromozomun uzun kolundaki parsiyel delesyon mental retardasyon, gelişme geriliği ve çeşitli konjenital malformasyonlarla karakterize nadir görülen kromozomal bir bozukluktur. Etkilenenlerin fenotipleri delesyonun lokasyon ve boyutuna göre değişkenlik gösterir. Santral sinir sistemi, kardiyak, genitoüriner, iskelet sistem malformasyonları ve kraniyofasyal dismorfizm bulguları gözlenebilir. Erken genetik sonogram ve karyotipleme ile prenatal tanısı mümkündür. Major malformasyonların eşlik etmediği mental retardasyon ve gelişme geriliğinin ön planda olduğu olgularda prenatal tanı zor olabilir. Bu olguda, 14. gebelik haftasında multipl anormal ultrason bulguları sonucu karyotipleme yapılarak prenatal dönemde 13-q sendromu tanısı konulan bir hasta tanımlanmıştır

Utero-cutaneous Fistula after Multiple Abdominal Myomectomies: A Case Report

Background: Utero-cutaneous fistula (UCF) is an extremely rare entity and only a few case reports have been published. Most UCFs develop secondary to postpartum or postoperative complications. Case Report: A 42 year-old woman began to complain from bleeding and malodorous discharge through her abdominal incision scar. The fistula tract with a thickness of 8 mm was observed between the uterus and wound using magnetic resonance imaging (MRI). The risks and benefits of conservative treatment have been discussed; the patient demanded definitive treatment, so hysterectomy and excision of the fistulous tract was performed. Histopathology of the fistulous tract showed endometrial epithelization of the tract lined by granulation. Conclusion: There are many causes of such an extremely rare entity. Patients should be counseled for medical or surgical treatment considering their age, accompanied uterine pathologies such as fibroids and fertility expectations

The effects of gestationalweight gain and maternal body mass index discrepancy on all stages of labor

Objective: To investigate the effects of maternal body mass index (BMI) and total weight gain during the pregnancy (WGDP) on all stages of labor. Material and Methods: This is a prospective case-control study carried out at a tertiary referral hospital during 1-year period of time. We divided study population into 4 groups according to BMI and classified women according to WGDP; inadequate, optimum, excessive. Then we assessed the maternal characteristics, cesarean rate, all variables of labor stages, delivery complications, operative delivery rates, and interventions such as; induction rate and episiotomy. Results: A total of 523 women were included in the study [n=55 (10.5%) cesarean section and n=468 (89.5%) vaginal delivery]. There were 435 pregnant Turkish women and 88 Syrian Refugees in the study population. Younger maternal age and need for episiotomy was more common in low-weight group than others. All stages of labor except transition stages (duration between 7 and 10 cm of cervical dilatation) was longer in obese group (222.9±35.6 min, 195.8±29.6 min, 200.6±30.4 min, 255.8±38.2 min in group 1,2,3 and 4, respectively) (p<0.05). We found no statistically significant effect of weight gain on the duration of labor. Conclusion: Either low and high pre-gestational BMI are found to lead to increased risk of adverse labor results in compatible with literature. Therefore, professionals should support weight loss or gain to achieve optimal BMI in women planning pregnancy

Novel Isatin-Schiff Base Cu (II) and Ni(II) Complexes. X-ray Crystal Structure of Bis[3-(4-hexylphenylimino)-1H-indol-2(3H)-one]- dichlorocopper(II) Complex

Schiff base ligand (HL) derived from 4-hexylaniline with isatin (1H-indole-2,3-dione) and its complexes with Cu(II), Ni(II) were prepared and characterized by analytical, spectroscopic (IR, UV-Vis, Mass) techniques, electrical conductivity, magnetic and thermal measurements. The crystal and molecular structure of [Cu(HL)(2)Cl-2] was determined by a single-crystal X-ray diffraction study. The molecular structure of the title compound has an inversion center on the Cu atom