Coronary venous angioplasty to a ring- like stricture preventing left ventricular lead insertion [Sol ventrikül lead implantasyonunu önleyen striktüre uygulanan koroner venöz anjiyoplasti]

PubMedID: 23618973[No abstract available

Raman spectroscopic hydration status assessment predicts histological score of osteoarthritic human cartilage specimens

WOS:000642588500190WOS:000642588500190Purpose: Water amount change in cartilage with osteoarthritis (OA) has been proposed as a promising biomarker for the early diagnosis of OA. The only clinically viable technique to assess hydration status of cartilage is Magnetic Resonance Imaging (MRI)-based T2 signal, but its implementation is not without limitation. Thus, there is still a need for a wide range of methods to assess hydration status of cartilage nondestructively. We recently established a new method to assess hydration status of cartilage using Raman spectroscopy (RS) which also allows us to probe zone-dependent cartilage water fractions with chemically high specificit

Raman spectroscopy-based water content is a negative predictor of articular human cartilage mechanical function

WOS:000456412900013PubMed:30359723Objective: Probing the change in water content is an emerging approach to assess early diagnosis of osteoarthritis (OA). We herein developed a new method to assess hydration status of cartilage non-destructively using Raman spectroscopy (RS), and showed association of Raman-based water and organic content measurement with mechanical properties of cartilage. We further compared Raman-based water measurement to gravimetric and magnetic resonance imaging (MRI)-based water measurement. Design: Eighteen cadaveric human articular cartilage plugs from 6 donors were evenly divided into two age groups: young (n = 9, mean age: 29.3 +/- 6.6) and old (n = 9, mean age: 64.0 +/- 1.5). Water content in cartilage was measured using RS, gravimetric, and MRI-based techniques. Using confined compression creep test, permeability and aggregate modulus were calculated. Regression analyses were performed among RS parameters, MRI parameter, permeability, aggregate modulus and gravimetrically measured water content. Results: Regardless of the method used to calculate water content (gravimetric, RS and MRI), older cartilage group consistently had higher water content compared to younger group. There was a stronger association between gravimetric and RS-based water measurement (R-g(2) = 0.912) than between gravimetric and MRI-based water measurement (R-c(2) = 0.530). Gravimetric and RS-based water contents were significantly correlated with permeability and aggregate modulus whereas MRI-based water measurement was not. Conclusion: RS allows for quantification of different water compartments in cartilage nondestructively, and estimation of up to 82% of the variation observed in the permeability and aggregate modulus of articular cartilage. RS has the potential to be used clinically to monitor cartilage quality noninvasively or minimally invasively with Raman probe during arthroscopy procedures. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.CWRUThis work was partially supported by think [box] at CWRU

THE PREDICTIVE VALUE OF ATRIAL CONDUCTION CHARACTERISTICS DETECTED BY TISSUE DOPPLER FOR THE INDUCIBILITY OF SUSTAINED ATRIAL FIBRILLATION

WOS: 000317946500518

The Prevalence of Periodontal Pathogenic Bacteria in Atherosclerotic Cardiovascular Disease

Background: A possible link between periodontal pathogenic bacteria and atherosclerosis may exist based on the inflammatory mechanisms initiated by bacteria found in periodontal lesions. Our aim was to investigate the presence of DNA originating from T. denticola, C. rectus, T. forsythia, and P. gingivalis in the vascular tissue specimens obtained from patients who underwent surgery for arteriosclerotic vascular disease in this study