The prediction of live weight of hair goats through penalized regression methods: LASSO and adaptive LASSO

The least absolute selection and shrinkage operator (LASSO) and adaptive LASSO methods have become a popular model in the last decade, especially for data with a multicollinearity problem. This study was conducted to estimate the live weight (LW) of Hair goats from biometric measurements and to select variables in order to reduce the model complexity by using penalized regression methods: LASSO and adaptive LASSO for γ = 0.5 and γ = 1. The data were obtained from 132 adult goats in Honaz district of Denizli province. Age, gender, forehead width, ear length, head length, chest width, rump height, withers height, back height, chest depth, chest girth, and body length were used as explanatory variables. The adjusted coefficient of determination (Radj2), root mean square error (RMSE), Akaike's information criterion (AIC), Schwarz Bayesian criterion (SBC), and average square error (ASE) were used in order to compare the effectiveness of the methods. It was concluded that adaptive LASSO (γ = 1) estimated the LW with the highest accuracy for both male (Radj2 = 0.9048; RMSE&thinsp; = &thinsp;3.6250; AIC&thinsp; = &thinsp;79.2974; SBC&thinsp; = &thinsp;65.2633; ASE&thinsp; = &thinsp;7.8843) and female (Radj2 = 0.7668; RMSE&thinsp; = &thinsp;4.4069; AIC&thinsp; = &thinsp;392.5405; SBC&thinsp; = &thinsp;308.9888; ASE&thinsp; = &thinsp;18.2193) Hair goats when all the criteria were considered.</p

Prediction of internal egg quality characteristics and variable selection using regularization methods: ridge, LASSO and elastic net

This study was conducted to determine the inner quality characteristics of eggs using external egg quality characteristics. The variables were selected in order to obtain the simplest model using ridge, LASSO and elastic net regularization methods. For this purpose, measurements of the internal and external characteristics of 117 Japanese quail eggs were made. Internal quality characteristics were egg yolk weight and albumen weight; external quality characteristics were egg width, egg length, egg weight, shape index and shell weight. An ordinary least square method was applied to the data. Ridge, LASSO and elastic net regularization methods were performed to remove the multicollinearity of the data. The regression estimating equations of the internal egg quality were significant for all methods (P &lt; 0.01). The goodness of fit of the regression estimating equations for egg yolk weight was 58.34, 59.17 and 59.11&thinsp;% for the ridge, LASSO and elastic net methods, respectively. For egg albumen weight the goodness of fit of the regression estimating equations was 75.60&thinsp;%, 75.94&thinsp;% and 75.81&thinsp;% for the respective ridge, LASSO and elastic net methods. It was revealed that LASSO, including two predictors for both egg yolk weight and egg albumen weight, was the best model with regard to high predictive accuracy.</p

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins' defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents

Anti-inflammatory effect of bee pollen ethanol extract from Cistus sp. of Spanish on carrageenan-induced rat hind paw edema

<p>Abstract</p> <p>Background</p> <p>Bee pollen, a honeybee product, is the feed for honeybees prepared themselves by pollens collecting from plants and has been consumed as a perfect food in Europe, because it is nutritionally well balanced. In this study, we aimed to investigate the anti-inflammatory effect of bee pollen from <it>Cistus </it>sp. of Spanish origin by a method of carrageenan-induced paw edema in rats, and to investigate the mechanism of anti-inflammatory action and also to elucidate components involved in bee pollen extracted with ethanol.</p> <p>Methods</p> <p>The bee pollen bulk, its water extract and its ethanol extract were administered orally to rats. One hour later, paw edema was produced by injecting of 1% solution of carrageenan, and paw volume was measured before and after carrageenan injection up to 5 h. The ethanol extract and water extract were measured COX-1 and COX-2 inhibitory activities using COX inhibitor screening assay kit, and were compared for the inhibition of NO production in LPS-stimulated RAW 264.7 cells. The constituents of bee pollen were purified from the ethanol extract subjected to silica gel or LH-20 column chromatography. Each column chromatography fractions were further purified by repeated ODS or silica gel column chromatography.</p> <p>Results</p> <p>The bee pollen bulk mildly suppressed the carrageenan-induced paw edema and the water extract showed almost no inhibitory activity, but the ethanol extract showed relatively strong inhibition of paw edema. The ethanol extract inhibited the NO production and COX-2 but not COX-1 activity, but the water extract did not affect the NO production or COX activities. Flavonoids were isolated and purified from the ethanol extract of bee pollen, and identified at least five flavonoids and their glycosides.</p> <p>Conclusions</p> <p>It is suggested that the ethanol extract of bee pollen show a potent anti-inflammatory activity and its effect acts <it>via </it>the inhibition of NO production, besides the inhibitory activity of COX-2. Some flavonoids included in bee pollen may partly participate in some of the anti-inflammatory action. The bee pollen would be beneficial not only as a dietary supplement but also as a functional food.</p

Are identities oral? Understanding ethnobotanical knowledge after Irish independence (1937-1939)

BACKGROUND: The Schools' Folklore Scheme (1937-1939) was implemented at a pivotal time in Irelands' political history. It resulted in a body of ethnological information that is unique in terms of when, why and how it was collected. This material consists of over 700,000 pages of information, including ethnomedicinal and ethnobotanical traditions, reflecting an oral identity that spans generations and that in many cases was not documented in writing until the 1930s. The intention of this study is to highlight the importance of the Schools' Folklore Scheme and to demonstrate an ethnographic approach based on recollections of original participants of the scheme, to further understand the material in the collection and the impact it had on the participants. METHODS: This study involves an analysis of both oral and archival data. Eleven semi-structured interviews with original participants of the scheme were carried out between April and September 2016. Their corresponding schools' archival contributions to the scheme were located, and ethnomedicinal information was analysed and compared with the participants' recollections. RESULTS: The majority of participants' stated the scheme had a positive impact on them. Five participants' recalled collecting ethnomedicinal information, and there was a direct correlation between three of the participants' ethnomedicinal recollections and their entries in the archives. One third of all the ethnomedicinal entries analysed included the use of a plant. There were 191 plant mentions and 64 plant species named. CONCLUSIONS: Contacting the original participants offers a novel approach of analysing this archival material. It provides a unique first-hand account of this historical initiative, an insight into how the scheme was implemented and how it impacted upon the children. The ethnomedicinal and ethnobotanical information provides an understanding of the medicinal practices in Ireland during the 1930s. The plant species that were both orally recalled by participants and documented in the archives are in keeping with key ethnomedicinal systems throughout the world

Performance of electronic and visual ear tags in lambs under extensive conditions in Turkey

The objective of this study was to evaluate the effectiveness of electronic and visual ear tags in animal traceability, and to investigate the effect of placement site on ear-tag retention in Akkaraman lambs under rural conditions. A total of 380 lambs were identified with electronic and visual ear tags. Electronic and visual ear tags displayed 98.9 and 98.7 % readability at the end of 7 months, and 98.0 and 98.0 % readability at the end of the first year after tagging, respectively. Regarding the placement site, it was observed that there was more loss in ear tags placed on the mid-point part of the ear than the first-quarter part from the head side, but the difference was not statistically significant (<i>P</i> > 0.05). Breakages and electronic failures were not recorded during this study. In conclusion, electronic and visual ear tags demonstrated similar on-farm efficiency for the identification of Akkaraman lambs and fulfilled the minimum efficiency of 98 % required by the International Committee for Animal Recording (ICAR) for an official animal identification device at the end of the first year after tagging. Based on the findings of the study, placement of the ear tag in a cranial position and near the base of the ear would be advised