Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II

Left ventricular hypertrophy leads to heart failure and represents a high risk leading to premature death. Cyclic nucleotides (cAMP and cGMP) play a major role in heart contractility and cyclic nucleotide phosphodiesterases (PDEs) are involved in different stages of advanced cardiac diseases. We have investigated their contributions in the very initial stages of left ventricular hypertrophy development. Wistar male rats were treated over two weeks by chronic infusion of angiotensin II using osmotic mini-pumps. Left cardiac ventricles were used as total homogenates for analysis. PDE1 to PDE5 specific activities and protein and mRNA expressions were explored

Intermittent Hypoxia-Induced Cognitive Deficits Are Mediated by NADPH Oxidase Activity in a Murine Model of Sleep Apnea

Background: In rodents, exposure to intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is associated with neurobehavioral impairments, increased apoptosis in the hippocampus and cortex, as well as increased oxidant stress and inflammation. Excessive NADPH oxidase activity may play a role in IH-induced CNS dysfunction. Methods and Findings: The effect of IH during light period on two forms of spatial learning in the water maze and well as markers of oxidative stress was assessed in mice lacking NADPH oxidase activity (gp91phox _/Y) and wild-type littermates. On a standard place training task, gp91phox _/Y displayed normal learning, and were protected from the spatial learning deficits observed in wild-type littermates exposed to IH. Moreover, anxiety levels were increased in wild-type mice exposed to IH as compared to room air (RA) controls, while no changes emerged in gp91phox _/Y mice. Additionally, wild-type mice, but not gp91phox _/Y mice had significantly elevated levels of NADPH oxidase expression and activity, as well as MDA and 8-OHDG in cortical and hippocampal lysates following IH exposures. Conclusions: The oxidative stress responses and neurobehavioral impairments induced by IH during sleep are mediated, at least in part, by excessive NADPH oxidase activity, and thus pharmacological agents targeting NADPH oxidase may provid

Evaluation Of Bamboo Leaf Ash As Supplementary Cementitious Material In Concrete

<p>Utilizing waste materials possessing pozzolanic properties in concrete production has become a global trend. Evaluating the pozzolanic activity of materials that replace cement is gaining significance due to the growing demand for environmentally sustainable cement products. Incorporating Bamboo Leaf Ash(BLA) as supplementary cementitious material(SCM) in concrete aligns with the principles of sustainable construction by reducing waste, utilizing renewable resources, and potentially lowering carbon emissions associated with traditional cement production. In this research work, BLA is used as partial replacement for ordinary Portland cement(OPC) in ranges of 10%, 20%, 30%. Fresh and hardened properties of concrete were investigated. Experimental results showed that, Concrete mix with BLA gives satisfactory cube compressive strength upto the replacement level of 20% with OPC as binder. Beyond 20% replacement, cube compressive strength falls below the characteristic strength of concrete.</p&gt

A Survey on Data Association Methods in VSLAM

Abstract In robotics the Simultaneous Localization and Mapping (SLAM

Synthesis and biological activity of some 3-methyl/ethoxycarbonyl-6- arylimidazo[2,1<i>-b</i>]thiazoles and their 5-bromo/5-formyl derivatives

393-398Facile reaction of arylacylbromide 1 with 2-amino-4- methylthiazole 2 and its hindered reaction with 2-amino-4-ethoxycarbonylthiazole 3 during the synthesis of 3-methyl/ethoxycarbonyl-6-aryl imidazo[2,1-b] thiazoles 8/9 are explained on the basis of electronic effects of the 4-substituent of thiazole substrate. Their bromination/formylation afforded the corresponding 5-bromo and 5-formyl derivatives . Results of preliminary screening of the target compounds reveal moderate anthelmintic and anti-inflammatory activity