71 research outputs found
4-Dimensional cellular automaton track finder for the CBM experiment
The CBM experiment (FAIR/GSI, Darmstadt, Germany) will focus on the measurement of rare probes at interaction rates up to 10 MHz with data flow of up to 1 TB/s. It requires a novel read-out and data-acquisition concept with self-triggered electronics and free-streaming data. In this case resolving different collisions is not a trivial task and event building must be performed in software online. That requires full online event reconstruction and selection not only in space, but also in time, so-called 4D event building and selection. This is a task of the First-Level Event Selection (FLES).The FLES reconstruction and selection package consists of several modules: track finding, track fitting, short-lived particles finding, event building and event selection. The Cellular Automaton (CA) track finder algorithm was adapted towards time-slice-based reconstruction and included into the CBMROOT framework. In this article, we describe the modification done to the algorithm, as well as the performance of the developed time-based approach
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Challenges in QCD matter physics --The scientific programme of the Compressed Baryonic Matter experiment at FAIR
Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sNN= 2.7--4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (ΞΌB> 500 MeV), effects of chiral symmetry, and the equation of state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2024, in the context of the worldwide efforts to explore high-density QCD matter
Π‘ΠΈΠ½ΡΠ΅Π· Π½ΠΎΠ²ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΡΠ΅ΠΌΠ°Π½ΡΠ°Π΄ΠΈΠ½Π° ΠΈ Π°Π΄Π°ΠΌΠ°Π½ΡΠ°Π½-1-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Ρ 1,2-Π°Π·ΠΎΠ»ΡΠ½ΡΠΌΠΈ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΠΌΠΈ
Various adamantane derivatives were obtained by the condensation of rimantadine with substituted hydroxy-benzaldehydes, esters and ethers based on them, as well as 1,2-azole-3-carbaldehydes, followed by reduction. Further acylation of derivatives with active amino and hydroxy groups yielded compounds containing two 1,2-azole fragments in one molecule.ΠΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΈΠ΅ΠΉ ΡΠ΅ΠΌΠ°Π½ΡΠ°Π΄ΠΈΠ½Π° Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΠΌΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ±Π΅Π½Π·Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π°ΠΌΠΈ, ΡΠ»ΠΎΠΆΠ½ΡΠΌΠΈ ΠΈ ΠΏΡΠΎΡΡΡΠΌΠΈ ΡΡΠΈΡΠ°ΠΌΠΈ Π½Π° ΠΈΡ
ΠΎΡΠ½ΠΎΠ²Π΅, Π° ΡΠ°ΠΊΠΆΠ΅ 1,2-Π°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π°ΠΌΠΈ Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π°Π·ΠΎΠΌΠ΅ΡΠΈΠ½ΠΎΠ² ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π²Π°ΡΠΈΠ°ΡΠΈΠ²Π½ΡΠ΅ Π°Π΄Π°ΠΌΠ°Π½ΡΠ°Π½ΠΎΠ²ΡΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅. ΠΠ°Π»ΡΠ½Π΅ΠΉΡΠΈΠΌ Π°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
Ρ Π°ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ Π°ΠΌΠΈΠ½ΠΎ- ΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΏΠ°ΠΌΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ Π² ΠΎΠ΄Π½ΠΎΠΉ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ Π΄Π²Π° 1,2-Π°Π·ΠΎΠ»ΡΠ½ΡΡ
ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°
Π‘ΠΈΠ½ΡΠ΅Π· ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ ΡΠ»ΠΎΠΆΠ½ΡΡ ΡΡΠΈΡΠΎΠ² Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ
Nicotinic (3-pyridinecarboxylic) acid is one of the most important vitamins as well as substance with versatile physiological activity, since it plays significant role in the human organism. Nicotinic acid (niacin, vitamin PP, vitamin B3) is widely used in medicine as drug which has a vasodilating effect, prevents the accumulation of cholesterol and normalizes the heart function. Isonicotinic (4-pyridinecarboxylic) acid is used for the production of valuable anti-tuberculosis drugs, antidepressants, etc. However, nicotinic and isonicotinic acids have various side effects: skin hyperemia, pruritus, formation of stomach peptic ulcers, liver dysfunction and hyperglycemia. To reduce the severity of side effects, their slightly soluble salts, esters or amides are obtained. The synthesis of nicotinic and isonicotinic acid esters with vanillin benzaldehydes, cholesterol, 8-hydroxyquinoline, quinine and (4,5-dichloroisothiazol-3-yl)methanol is described. Esters were obtained by acylation of hydroxybenzaldehydes and alcohols with nicotinic and isonicotinic acid hydrochlorides in the presence of triethylamine in anhydrous methylene chloride. The IR- UV- and NMR spectra of the compounds obtained are presented.ΠΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΠΈΠ³ΡΠ°Π΅Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΡΠΎΠ»Ρ Π² ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°; ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΡΡΡ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅, Π° ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π½Π° Π΅Π΅ ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ ΡΠΎΡΡΠ΄ΠΎΡΠ°ΡΡΠΈΡΡΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅, ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ°ΡΡ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π°, Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ΅ΡΠ΄ΡΠ°. ΠΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΡΡ (4-ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ) ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΡΡΡΡ Π΄Π»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π²Π΅ΡΡΠΌΠ° ΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², Π² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅ Π°Π½ΡΠΈΠ΄Π΅ΠΏΡΠ΅ΡΡΠ°Π½ΡΠΎΠ² ΠΈ Π΄Ρ. ΠΠ΄Π½Π°ΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°ΡΡ ΠΏΠΎΠ±ΠΎΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ: Π³ΠΈΠΏΠ΅ΡΠ΅ΠΌΠΈΡ ΠΊΠΎΠΆΠΈ, Π·ΡΠ΄, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ·Π² ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°, Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ, Π³ΠΈΠΏΠ΅ΡΠ³Π»ΠΈΠΊΠ΅ΠΌΠΈΡ. ΠΠ»Ρ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎΠ±ΠΎΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΡΡΡΡ ΠΈΡ
ΠΌΠ°Π»ΠΎΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΡΠ΅ ΡΠΎΠ»ΠΈ, ΡΡΠΈΡΡ, Π°ΠΌΠΈΠ΄Ρ. ΠΠΏΠΈΡΠ°Π½ ΡΠΈΠ½ΡΠ΅Π· ΡΠ»ΠΎΠΆΠ½ΡΡ
ΡΡΠΈΡΠΎΠ² Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ Ρ Π±Π΅Π½Π·Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π°ΠΌΠΈ Π²Π°Π½ΠΈΠ»ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ΄Π°, Π° ΡΠ°ΠΊΠΆΠ΅ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½ΠΎΠΌ, 8-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΡ
ΠΈΠ½ΠΎΠ»ΠΈΠ½ΠΎΠΌ, Ρ
ΠΈΠ½ΠΈΠ½ΠΎΠΌ ΠΈ (4,5-Π΄ΠΈΡ
Π»ΠΎΡΠΈΠ·ΠΎΡΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΠΎΠ»ΠΎΠΌ. Π‘Π»ΠΎΠΆΠ½ΡΠ΅ ΡΡΠΈΡΡ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Π°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ΅ΡΠΈΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ±Π΅Π½Π·Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄ΠΎΠ² ΠΈ ΡΠΏΠΈΡΡΠΎΠ² Π³ΠΈΠ΄ΡΠΎΡ
Π»ΠΎΡΠΈΠ΄Π°ΠΌΠΈ Ρ
Π»ΠΎΡΠ°Π½Π³ΠΈΠ΄ΡΠΈΠ΄ΠΎΠ² Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΡΡΠΈΡΡΠΈΠ»Π°ΠΌΠΈΠ½Π° Π² Π±Π΅Π·Π²ΠΎΠ΄Π½ΠΎΠΌ Ρ
Π»ΠΎΡΠΈΡΡΠΎΠΌ ΠΌΠ΅ΡΠΈΠ»Π΅Π½Π΅. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΠ- Π£Π€- ΠΈ Π―ΠΠ -ΡΠΏΠ΅ΠΊΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
ΠΠΠΠΠΠΠΠΠΠΠΠΠΠ’ΠΠ«Π Π‘ΠΠ‘Π’ΠΠΠ« Π‘ Π’Π ΠΠ₯Π€ΠΠΠΠ«Π Π ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ
A review of scientific publications that describe systems with a three-phase splitting region is presented. Mechanisms of a three-phase splitting region formation are shown. All the suggested classifications of diagrams with a three-phase splitting region are presented. Methods for studying the evolution of a three-phase splitting region are described. Problems connected with the mathematical modeling of liquid - liquid - liquid equilibrium are considered. The ability of mixtures to form three-phase splitting regions and opportunities of separating such mixtures by special methods is analyzed. A list of known systems with three and more liquid phases is presented.Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΎΠ±Π·ΠΎΡ Π½Π°ΡΡΠ½ΡΡ
ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌ Ρ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΡΠΌ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ, ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΠΌΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΠ»Π°ΡΡΠΎΠ². Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΡ. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΏΡΠΈΠΌΠ΅ΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ Π΄ΠΈΠ°Π³ΡΠ°ΠΌΠΌ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΡ ΠΌΠ½ΠΎΠ³ΠΎΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ ΠΈ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΡ. Π’Π°ΠΊΠΆΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠΈΡ ΠΆΠΈΠ΄ΠΊΠΎΡΡΡ-ΠΆΠΈΠ΄ΠΊΠΎΡΡΡ-ΠΆΠΈΠ΄ΠΊΠΎΡΡΡ ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠΌΠ΅ΡΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²ΡΠ²Π°ΡΡ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΌΠ΅ΡΠ΅ΠΉ ΡΠΊΡΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ, ΡΠΎΡΠ΅ΡΠ°ΡΡΠΈΠΌΠΈ ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΈ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΠ΅. ΠΡΠΈΠ²Π΅Π΄Π΅Π½ ΡΠΏΠΈΡΠΎΠΊ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΡΠΈΡΡΠ΅ΠΌ Ρ ΡΡΠ΅ΠΌΡ ΠΈ Π±ΠΎΠ»Π΅Π΅ ΠΆΠΈΠ΄ΠΊΠΈΠΌΠΈ ΡΠ°Π·Π°ΠΌΠΈ
Π‘ΠΈΠ½ΡΠ΅Π· ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ½ΡΡ ΠΈ ΠΈΠ·ΠΎΡΠΈΠ°Π·ΠΎΠ»ΡΠ½ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π°
Curcumin is a chemical compound with antioxidant properties as well as strong anti-inflammatory, antiviral, analgesic, antimicrobial and antitumor effect, contained in the tuberous rhizomes of the turmeric plant (Curcuma longa). Curcumin derivatives are being intensively studied as potential drugs β antitumor drugs for the treatment of certain forms of cancer. The presence of reactive functional groups makes curcumin a convenient starting compound for the further chemical modification. The esters of curcumin and 5-phenylisoxazole-3-carboxylic acid, 5-(p-tolyl)isoxazole-3-carboxylic acid, 4,5- dichloroisothiazole-3-carboxylic acid and adduct of 5-(p-tolyl)isoxazol-3-carbaldehyde with curcumin were synthesized. Esters were obtained by acylation of curcumin with heterocycle-containing carboxylic acid chloride in diethyl ether in the presence of triethylamine. The IR and NMR spectra of the obtained compounds are described.ΠΡΡΠΊΡΠΌΠΈΠ½ β Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π΅ΡΡ Π² ΠΊΠ»ΡΠ±Π½Π΅Π²ΠΈΠ΄Π½ΡΡ
ΠΊΠΎΡΠ½Π΅Π²ΠΈΡΠ°Ρ
ΡΠ°ΡΡΠ΅Π½ΠΈΡ ΠΊΡΡΠΊΡΠΌΠ° ΠΈ ΠΎΠ±Π»Π°Π΄Π°ΡΡΠ΅Π΅ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΠ΅Π΅ ΡΠΈΠ»ΡΠ½ΠΎΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅, ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠ΅, Π±ΠΎΠ»Π΅ΡΡΠΎΠ»ΡΡΡΠ΅Π΅, Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ΅ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ. ΠΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΡΡΡΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² β ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π΄Π»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΡΠΎΡΠΌ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΠ»Π°Π³ΠΎΠ΄Π°ΡΡ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΡ Π² Π΅Π³ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠ΅Π°ΠΊΡΠΈΠΎΠ½Π½ΠΎΡΠΏΠΎΡΠΎΠ±Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΠΆΠΈΡΡ ΡΠ΄ΠΎΠ±Π½ΡΠΌ ΠΈ Π»Π΅Π³ΠΊΠΎΠ΄ΠΎΡΡΡΠΏΠ½ΡΠΌ ΠΈΡΡ
ΠΎΠ΄Π½ΡΠΌ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ΠΌ Π΄Π»Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ. ΠΠΏΠΈΡΠ°Π½ ΡΠΈΠ½ΡΠ΅Π· ΡΠ»ΠΎΠΆΠ½ΡΡ
ΡΡΠΈΡΠΎΠ² ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° ΠΈ 5-ΡΠ΅Π½ΠΈΠ»ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ, 5-(Ρ-ΡΠΎΠ»ΠΈΠ»)ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ, 4,5-Π΄ΠΈΡ
Π»ΠΎΡΠΈΠ·ΠΎΡΠΈΠ°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ ΠΈ Π°Π΄Π΄ΡΠΊΡΠ° 5-(Ρ-ΡΠΎΠ»ΠΈΠ»)ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π° Ρ ΠΊΡΡΠΊΡΠΌΠΈΠ½ΠΎΠΌ. Π‘Π»ΠΎΠΆΠ½ΡΠ΅ ΡΡΠΈΡΡ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Π°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° Ρ
Π»ΠΎΡΠ°Π½Π³ΠΈΠ΄ΡΠΈΠ΄Π°ΠΌΠΈ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Π² ΡΡΠ΅Π΄Π΅ Π΄ΠΈΡΡΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠΈΡΠ° Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΡΡΠΈΡΡΠΈΠ»Π°ΠΌΠΈΠ½Π°. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΠ- ΠΈ Π―ΠΠ -ΡΠΏΠ΅ΠΊΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
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