サンジュウ トウリツ フリコ ノ アンテイカ セイギョ

The purpose of this study is to design and realize a digital control svstem stabilizing a triple inverted pendulum. The stabilizing control of a triple inverted pendulum is much more difficult than a single or double inverted pendulum. There is very little study on this control. The system tested consists of a triple inverted pendulum, a cart, an electric servo motor and a personal computer PC-9801RA. The results obtained can be summarized as follows : 1) Stabilized zone of a single, double and triple inverted pendulum are calculated for a maximum cart position of 0.9 m. When coulomb friction is ignored, the stabilized zone of a triple pendulum exists, but is is much smaller than those of a single or double pendulum. When coulomb friction is considered, there is no stabilized zone of a triple pundulum. 2) When a maximum cart position is 1.8 m and control input voltage compensating coulomb friction is 0.12 v, feedback gains with which a triple inverted pendulum can be stabilized for 12 seconds can be obtained by a computer simulation. In a real control system, however, a triple inverted pendulum can not be stabilized even for one second. Thus it is understood that the real time stabilizing control of a triple inverted pendulum is very difficult because of existing nonlinear friction

EGFR mutation and ALK fusion-positive non-small cell lung cancer: a multicenter prospective cohort study in Nagano Prefecture, Japan

Introduction. We prospectively examined current clinical practices in patients with inoperable epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) fusion-positive (EGFR+ and ALK+, respectively) non-small cell lung cancer (NSCLC) in Nagano Prefecture, Japan.  Material and methods. The study population consisted of newly diagnosed patients with inoperable EGFR+ and ALK+ NSCLC in 14 hospitals in Nagano between May 2016 and March 2019. Both initial and subsequent treatment decisions were made at the discretion of the attending physician.  Results. A total of 281 patients with EGFR+ NSCLC (mean age, 74 years, 59.1% female) and 26 patients with ALK+ NSCLC (mean age, 66 years, 53.8% female) were included in the study. The study population consisted of 148/107/29/20/3 cases with performance status 0/1/2/3/4 and 6/2/31/194/75 cases with clinical stage I/II/III/IV/recurrence, respectively. First-line therapy with tyrosine kinase inhibitors was performed in 259 (92.2%) and 22 (84.6%) patients with EGFR+ and ALK+ NSCLC, respectively. The median overall survival rate was 41.2 months (95% CI 36.8–45.6 months) with EGFR+. It was not reached with ALK+ .  Conclusions. This observational analysis represents a valuable resource for evaluating the outcomes of treatment in patients with NSCLC

<b>Continuous Time Random Walk and different diffusive regimes</b> - doi: 10.4025/actascitechnol.v34i2.11521

<p class="aresumo">We investigate how it is possible to obtain different diffusive regimes from the Continuous Time Random Walk (CTRW) approach performing suitable changes for the waiting time and jumping distributions in order to get two or more regimes for the same diffusive process. We also obtain diffusion-like equations related to these processes and investigate the connection of the results with anomalous diffusion.</p><p class="apalavrachave"> </p

Spin-Polarized Radicals with Extremely Long Spin-Lattice Relaxation Time at Room Temperature in a Metal-Organic Framework

The generation of spin polarization is key in quantum information science and dynamical nuclear polarization. Polarized electron spins with long spin-lattice relaxation times (T1) at room temperature are important for these applications, but have been difficult to achieve. We report the realization of spin-polarized radicals with extremely long T1 at room temperature in a metal-organic framework (MOF) in which azaacene chromophores are densely integrated. Persistent radicals are generated in the MOF by charge separation after photoexcitation. Spin polarization of triplet generated by photoexcitation are successfully transferred to the persistent radicals. Pulse ESR measurements reveal that the T1 of the polarized radical in the MOF is as long as 274 s at room temperature. The achievement of extremely long spin polarization in MOFs with nanopores accessible to guest molecules will be an important cornerstone for future highly sensitive quantum sensing and efficient dynamic nuclear polarization

Efficacy and Safety of Carbon Ion Radiotherapy in Bone and Soft Tissue Sarcomas

PURPOSE: To evaluate the tolerance for and effectiveness of carbon ionradiotherapy in patients with unresectable bone and soft tissue sarcomas.\nPATIENTS AND METHODS: We conducted a phase I/II dose escalation study ofcarbon ion radiotherapy. Fifty-seven patients with 64 sites of bone and softtissue sarcomas not suited for resection received carbon ion radiotherapy.Tumors involved the spine or paraspinous soft tissues in 19 patients, pelvisin 32 patients, and extremities in six patients. The total dose ranged from52.8 to 73.6 gray equivalent (GyE) and was administered in 16 fixedfractions over 4 weeks (3.3 to 4.6 GyE/fraction). The median tumor size was559 cm3 (range, 20 to 2,290 cm3). The minimum follow-up was 18 months.\nRESULTS: Seven of 17 patients treated with the highest total dose of 73.6GyE experienced Radiation Therapy Oncology Group grade 3 acute skinreactions. Dose escalation was then halted at this level. No other severeacute reactions (grade > 3) were observed in this series. The overall localcontrol rates were 88% and 73% at 1 year and 3 years of follow-up,respectively. The median survival time was 31 months (range, 2 to 60months), and the 1- and 3-year overall survival rates were 82% and 46%,respectively.\nCONCLUSION: Carbon ion radiotherapy seems to be a safe and effectivemodality in the management of bone and soft tissue sarcomas not eligible forsurgical resection, providing good local control and offering a survivaladvantage without unacceptable morbidity