Resonant tunneling and Fano resonance in quantum dots with electron-phonon interaction

We theoretically study the resonant tunneling and Fano resonance in quantum dots with electron-phonon (e-ph) interaction. We examine the bias-voltage ($V$) dependence of the decoherence, using Keldysh Green function method and perturbation with respect to the e-ph interaction. With optical phonons of energy $\omega_0$, only the elastic process takes place when $eV<\omega_0$, in which electrons emit and absorb phonons virtually. The process suppresses the resonant amplitude. When $eV>\omega_0$, the inelastic process is possible which is accompanied by real emission of phonons. It results in the dephasing and broadens the resonant width. The bias-voltage dependence of the decoherence cannot be obtained by the canonical transformation method to consider the e-ph interaction if its effect on the tunnel coupling is neglected. With acoustic phonons, the asymmetric shape of the Fano resonance grows like a symmetric one as the bias voltage increases, in qualitative accordance with experimental results.Comment: 28 pages, 11 figure

Polyamine depletion induces G1 and S phase arrest in human retinoblastoma Y79 cells

<p>Abstract</p> <p>Background</p> <p>Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G₁arrest through dephosphorylation of retinoblastoma protein (pRb). The effect of DFMO on cell growth of pRb deficient cells is not known. We examined the effects of DFMO on pRb deficient human retinoblastoma Y79 cell proliferation and its molecular mechanism.</p> <p>Methods</p> <p>Using cultured Y79 cells, the effects of DFMO were studied by using polyamine analysis, western blot, gel shift, FACS and promoter analysis.</p> <p>Results</p> <p>DFMO suppressed the proliferation of Y79 cells, which accumulated in the G1 and S phase. DFMO induced p27/Kip1 protein expression, p107 dephosphorylation and accumulation of p107/E2F-4 complex in Y79 cells.</p> <p>Conclusion</p> <p>These results indicate that p107 dephosphorylation and accumulation of p107/E2F-4 complex is involved in G₁and S phase arrest of DFMO treated Y79 cells.</p

A Comparative Study Of Certification Systems Based On Ethical Codes Of Medical Information On The Internet

Access to medical information has increased all over the world with the increase in Internet usage. Therefore, it is imperative to ensure the quality of medical information on the Internet. In this study, nine organizations having ethical codes relating to medical information on the Internet were subjects. Of these, ethical codes were compared on the basis of form and content. The certification systems were compared on the basis of number of certified websites, number of certified countries, cost to certify, process of certification and term of certification. As this result, here were only a few differences in form although each ethical code emphasized different content. It is unclear which certification system was the best, as all had advantages and disadvantages. The promotion of a certification system needs support from governments or other organizations. In conclusion, we propose three steps to ensure quality and control medical information online: (1) update the ethical code at least annually, (2) work with other organizations to enforce ethical codes and certification systems, and (3) raise awareness of these approaches

<Reports on the Nineteenth Annual Meeting of the Tsukuba English Linguistic Society> A Semantic Approach to Verbal Prefixation : With Special Reference to Prefix Over

In this joint reaearch, we are concerned with the words which have the form of "over- + V". The prefix has two senses: one is spatial/temporal sense, and the other is an "excessive" sense. Specifically, we focus on the later case. The excessive over- is notable for some grammatical phenomena. ..

Effect modification by temperature on the association between O3 and emergency ambulance dispatches in Japan: A multi-city study

Numerous epidemiological studies have reported that ozone (O₃) and temperature are independently associated with health outcomes, but modification of the effects of O₃ on health outcomes by temperature, and vice versa, has not been fully described. This study aimed to investigate effect modification by temperature on the association between O₃ and emergency ambulance dispatches (EADs) in Japan. Data on daily air pollutants, ambient temperature, and EADs were obtained from eight Japanese cities from 2007 to 2015. A distributed lag non-linear model combined with Poisson regression was performed with temperature as a confounding factor and effect modifier to estimate the effects of O₃ on EADs at low (75th percentile) temperature for each city. The estimates obtained from each city were pooled by random-effects meta-analysis. When temperature was entered as a confounder, the estimated effects of O₃ on EADs for all acute, cardiovascular, and respiratory illnesses were largest at lag 0 (current-day lag). Therefore, this lag was used to further estimate the effects of O₃ on EADs in each temperature category. The estimated effects of O₃ on EADs for all acute, cardiovascular, and respiratory illnesses in all eight Japanese cities increased with increasing temperature. Specifically, a 10 ppb increase in O₃ was associated with 0.80 % (95 % CI: 0.25 to 1.35), 0.19 % (95 % CI: -0.85 to 1.25), and 1.14 % (95 % CI: -0.01 to 2.31) increases in the risk of EADs for all acute, cardiovascular, and respiratory illnesses, respectively, when city-specific daily temperature exceeded the 75th percentile. Our findings suggest that the association between O₃ and EADs for all acute, cardiovascular, and respiratory illnesses is the highest during high temperature. Finding of this study can be used to develop potential mitigation measures against O₃ exposure in high temperature environment to reduce its associated adverse health effects

Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression

Glycosylphosphatidylinositol (GPI)-anchored proteins play crucial roles in various enzyme activities, cell signaling and adhesion, and immune responses. While the molecular mechanism underlying GPI-anchored protein biosynthesis has been well studied, the role of zinc transport in this process has not yet been elucidated. Zn transporter (ZNT) proteins mobilize cytosolic zinc to the extracellular space and to intracellular compartments. Here, we report that the early secretory pathway ZNTs [ZNT5-ZNT6 heterodimers (ZNT5-6) and ZNT7-ZNT7 homodimers (ZNT7)], which supply zinc to the lumen of the early secretory pathway compartments are essential for GPI-anchored protein expression on the cell surface. We show, using overexpression and gene disruption/re-expression strategies in cultured human cells, that loss of ZNT5-6 and ZNT7 zinc transport functions results in significant reduction in GPI-anchored protein levels similar to that in mutant cells lacking phosphatidylinositol glycan anchor biosynthesis (PIG) genes. Furthermore, medaka fish with disrupted Znt5 and Znt7 genes show touch-insensitive phenotypes similar to zebrafish Pig mutants. These findings provide a previously unappreciated insight into the regulation of GPI-anchored protein expression and protein quality control in the early secretory pathway