男子つり輪における「背面水平懸垂から十字懸垂」(ナカヤマ)の技術習得のためのプロセスについて

In the gymnastics, to acquire one technique, a lot of elements such as physical strength, skills, and tools influence. Because the nature, physical fitness, the skill, and the motivation, etc. are different depending on the gymnast, it is thought that the teaching process for acquisition of a technique is also dfferent. In the present study, "Nakayama" in the rings decided to be paid to attention, and to clarify a necessary factor for the technological acquisition. As a result, it was clarified to Nakayama\u27s acquisition that the development of how to handle the advancement of an improvement of the protector and supplementary apparatus and the techniques and the practice method strongly influenced

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness

Excess iron causes cancer and is thought to be related to carcinogenesis and cancer progression including stemness, but the details remain unclear. Here, we hypothesized that stemness in cancer is related to iron metabolism and that regulating iron metabolism in cancer stem cells (CSCs) may be a novel therapy. In this study, we used murine induced pluripotent stem cells that expressed specific stem cell genes such as Nanog, Oct3/4, Sox2, Klf4, and c-Myc, and two human cancer cell lines with similar stem cell gene expression. Deferasirox, an orally available iron chelator, suppressed expression of stemness markers and spherogenesis of cells with high stemness status in vitro. Combination therapy had a marked antitumor effect compared with deferasirox or cisplatin alone. Iron metabolism appears important for maintenance of stemness in CSCs. An iron chelator combined with chemotherapy may be a novel approach via suppressing stemness for CSC targeted therapy