52 research outputs found

    事例報告 : 研究者によるORCIDの情報登録と活⽤例について

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    「ORCID(Open Researcher and Contributor ID)」説明会 日時:令和元年12月20日(金)15:00-17:00 場所:筑波大学 大学会館国際会議室 主催:筑波大学研究推進部・学術情報

    Guest editorial: Application of cloud energy storage systems in power systems

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    Cloud energy storage system (CESS) technology is a novel idea to eliminate the distributed energy storage systems from the consumers into a cloud service centre, where CESS acts as a virtual energy storage capacity instead of the actual devices. The power and energy of several distributed energy storages are combined using a CESS to assure providing storage services for small consumers. A CESS is a shared pool of grid-scale energy storage systems to reduce the cost of energy storage services in the power system which can increase the penetration level of onsite distributed renewable energy sources, reduce the electricity bills of consumers, and provide flexibility to the power grid by reducing the peak loads. The current Special Issue aims to explore technologies, methodologies, and solutions to develop CESSs with an efficient, secure, and stable operation of power systems.Scopu

    The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

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    「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection
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