PAPILLARY HIDRADENOMA OF VULVA: A RARE CASE PRESENTATION

Papillary hidradenomas in the vulva arise from specialized anogenital mammary-like glands in and around the intralabial sulcus. These are benign lesions, which present as slow-growing, circumscribed cystic masses. Histologically, papillary hidradenomas are characterized by glandular structures and complex branching papillae with fibrovascular stalks. The glands are lined by myoepithelial cells and epithelial secretory cells with surrounding fibrous stroma. Oestrogen and progesterone receptors are potential markers to differentiate between anogenital sweat glands and conventional sweat glands. We intend to present a case of excoriating papillary hidradenoma of the vulva in a 23-year old female with a review of the literature. Keywords: Papillary hidradenoma, Vulva, Benign Tumor

Dermatofibrosarcoma Protuberans of Male Breast: An Unusual Presentation

Dermatofibrosarcoma protuberans (DFSP) is a rare tumor which usually presents during early or middle adult life, as erythematous indurated firm subcutaneous nodules. DFSP involving the breast is a rare phenomenon and even rarer in males. We describe a case of a male patient who presented with this tumor in his left breast

Total Serum Cholesterol Level in Cases of Carcinoma Breast – A Correlative Study

Aims and Objective: Correlation between serum cholesterol level and risk of breast cancer. Material and Methods: Fifty histologically diagnosed breast cancer patients were included in the study. Patients were grouped according to the size, histological type of the tumor and lymph node involvement. Patient’s total serum cholesterol levels were measured a week prior to the operation and on the 14th day postoperatively. Fifty age-matched non-cancer females were treated as a control. Observations: The pre and postoperative mean total serum cholesterol (MTSC) was found to be 272.3 ± 43.4mg/dl and 210.54 ± 31.5mg/dl respectively. An MTSC level in fifty control cases was found to be 183.42 ± 34.4mg/dl. Patients with tumor size less than 5cms showed preoperative mean serum cholesterol levels of 261.6 ± 36.5mg/dl and a postoperative value of 201.9 ± 16.9mg/dl while those with tumor size more than 10cms showed a mean serum cholesterol level of 282.36 ± 64.8mg/dl preoperatively and 211.82 ± 53.15mg/dl postoperatively. Thirty patients with scirrhous type of carcinoma had a preoperative mean serum cholesterol level as 237.36mg/dL, and twelve patients with a colloid type of carcinoma showed a preoperative level of 294.9 ± 18.4mg/dL whereas eight patients with medullary type of carcinoma showed the highest preoperative level of 324.3 ± 19.8mg/dL, whereas the corresponding postoperative values were 202.9 ± 30.0mg, 216.8 ± 27.8mg and 229.4 ± 29.8mg respectively. Conclusions: The present study helps us to conclude that dietary habits affect the association of cholesterol in breast cancer and size, histology with tumor metastasis effects such relationship

Nasal glioma with psammomatous calcification- An unusual presentation

Congenital midline swellings of nose are encountered rarely, and nasal gliomas constitute about 5% of such lesions. Various theories have been suggested to explain the pathogenesis. Imaging preferably by MRI is mandated to study the extent and to rule out intracranial extension. Clinically, these masses are firm and incompressible. Histologically, they are made up of astrocytes and neuroglial cells, embedded in fibrous and vascular connective tissue. The mainstay of treatment is conservative surgical excision because nasal gliomas are slow-growing, rarely recurrent, and have no malignant potential. We present a case of congenital extranasal glioma with psammomatous calcification and without any intracranial extension in an eighteen month old boy.--------------------------------------------Cite this article as: Sherwani RK, Akhtar K, Ray PS, Ahmad SS. Nasal glioma with psammomatous calcification- An unusual presentation. Int J  Cancer Ther Oncol 2014; 2(2):02027. DOI: 10.14319/ijcto.0202.

Xanthogranulomatous Pyelonephritis: A Rare Presentation

Xanthogranulomatous pyelonephritis is an uncommon chronic destructive disease process of renal parenchyma, associated with recurrent urinary tract infection. It is seen predominantly in females with no age specificity. The most common symptoms are flank or abdominal pain, fever, palpable mass, and gross hematuria. The common laboratory findings are leukocytosis and anemia. Urine cultures most often reveal Escherichia coli and Proteus mirabilis. Computed tomography is the mainstay of diagnostic imaging for xanthogranulomatous pyelonephritis. Histologically, xanthogranulomatous pyelonephritis presents a granulomatous inflammatory infiltrate mainly composed of lymphocytes, plasma cells, foamy histiocytes, and multinucleated giant cells. The differential diagnosis includes clear cell renal cell carcinoma, sarcomatoid renal cell carcinoma, leiomyosarcoma, malakoplakia, tuberculosis, and interstitial nephritis. Treatment includes antibiotics and surgery. In this article, we report a case of xanthogranulomatous pyelonephritis in a 38-year-old male patient with recurrent urinary tract infection

Histopathological Study of Subacute Toxic Effects of Chloroacetic Acid on Albino Rats and its Correlation with Serum Levels of Malondialdehyde

Human beings are increasingly being exposed to chloroacetic acid (CAA), a type of halo acetic acid. It would not be an exaggeration to say that almost the whole humankind today is affected by it or its metabolites. The concern over the carcinogenicity of haloacetic acids led the United States Environmental Protection Agency to regulate the allowable concentration of haloacetic acids in drinking water as part of the Disinfectants and Disinfection Byproducts Rule promulgated in 1998. Keeping this view in mind, the present study on histolopathological evaluation of different types of tissues viz., brain, kidney, liver, spleen and testes of Rattus norvegicus was performed, to find out the subacute toxicity of chloroacetic acid and correlation between CAA administration and changes in malondialdehyde (MDA) level in blood

Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance

SIGNIFICANCE: India has one of the highest rates of oral squamous cell carcinoma (OSCC) in the world, with an incidence of 15 per 100,000 and more than 70,000 deaths per year. The problem is exacerbated by a lack of medical infrastructure and routine screening, especially in rural areas. New technologies for oral cancer detection and timely treatment at the point of care are urgently needed. AIM: Our study aimed to use a hand-held smartphone-coupled intraoral imaging device, previously investigated for autofluorescence (auto-FL) diagnostics adapted here for treatment guidance and monitoring photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence (FL). APPROACH: A total of 12 patients with 14 buccal mucosal lesions having moderately/well-differentiated micro-invasive OSCC lesions (1.65 at the time of treatment were associated with successful outcomes. CONCLUSION: These results indicate the utility of a low-cost, handheld intraoral imaging probe for image-guided PDT and treatment monitoring while also laying the groundwork for an integrated approach, combining cancer screening and treatment with the same hardware

Synchronous Ovarian Carcinoma with Colorectal Metastases: An Unusual Presentation

This report describes the case of a 50-yearold female patient who presented with bilateral adnexal lump and dysfunctional uterine bleeding with altered bowel habits. Computed tomography of the abdomen and pelvis revealed a bilateral adnexal lump situated in both the ovaries and a lobular mass of 8 cm in the rectum. Proctoscopy revealed an elevated irregular rectal lesion. The microscopic examination of the ovarian lump revealed a bilateral serous adenocarcinoma with a papillary pattern with psammomatous calcification. A left hemicolectomy with lymphadenectomy was also performed. Immunohistochemical staining was positive for cytokeratin 7 and negative for cytokeratin 20. The use of immunohistochemistry demonstrated the tumor to be of ovarian origin. We report this case of synchronous involvement of the ovary and the colorectum because of its rarity and unusual presentation

Acute Promyelocytic Leukemia, Hypogranular Variant: A Rare Presentation

Early diagnosis of acute promyelocytic leukemia (APL) is essential because of its associated life threatening coagulopathy and unique response to all trans-retinoic acid (ATRA) therapy. The characteristic cell morphology supplemented by cytochemistry offers the most rapid means for diagnosis. Here we describe a rare case of acute promyelocytic leukemia-hypogranular variant that poses particular diagnostic challenge