Fundamentals of Retail: Measuring the Effect on Brand Value

Retail is important for every company. Some fundamentals commonly identified with respect to retail management are availability, visibility, shelf share management, category management, trade endorsement, and out of the box activities. These fundamentals are very important and a company should take care of them as the brand value of products is at stake. The objective of this research is to see whether the brand value is affected or altered by the fundamentals of retail. From the survey and analysis, it was concluded that trade endorsement and shelf-share are not likely to be the inhibitors of brand value. Keywords: Retail, Fundamentals, Brand Valu

What Makes Student’s Click: An Investigation on Student Consumer Decisions from Karachi.

In Pakistan’s most sectors of the economy, it can be seen that companies, FMCG’s and other conglomerates are now in the gradual generalization of their brands and are now even more reluctant to use them in the local context while planning on growing to other frontiers. The purpose of this study is to analyze the impact of market reputation, brand value, promotions and customer reviews on purchase decisions of students when they are opting for a brand on the basis of its image, attributes, likeability Information was collected from students of 5 universities in Karachi via the use of Quota sampling. Utilizing this approach, a Questionnaires based on likert scale (1-5) was floated. After conducting exploratory factor analysis for validity, Cronbach’s alpha for reliability of the constructs, multiple linear regression and partial correlation was used to test the stated hypotheses, it was seen that mainstream concept of marketing and advertising, Customer reviews and a brand’s market reputation  purchasing a brand have now become a significant predictor on the purchase of the brand.  Since marketing and promotions are now regular techniques, customers are now aware of this and tend to go for brands they consider are higher in value to them rather than cheap promotions to sell a product. Keywords: Brand Value, Materialism, Regret, Skepticism towards Advertising, Purchase Decision

Flow-Aware Elephant Flow Detection for Software-Defined Networks

Software-defined networking (SDN) separates the network control plane from the packet forwarding plane, which provides comprehensive network-state visibility for better network management and resilience. Traffic classification, particularly for elephant flow detection, can lead to improved flow control and resource provisioning in SDN networks. Existing elephant flow detection techniques use pre-set thresholds that cannot scale with the changes in the traffic concept and distribution. This paper proposes a flow-aware elephant flow detection applied to SDN. The proposed technique employs two classifiers, each respectively on SDN switches and controller, to achieve accurate elephant flow detection efficiently. Moreover, this technique allows sharing the elephant flow classification tasks between the controller and switches. Hence, most mice flows can be filtered in the switches, thus avoiding the need to send large numbers of classification requests and signaling messages to the controller. Experimental findings reveal that the proposed technique outperforms contemporary methods in terms of the running time, accuracy, F-measure, and recall

Current trends in the treatment of hepatitis C

Viral hepatitis, an inflammatory liver disease, is caused by various genotypes of hepatitis C viruses (HCV). Hepatitis C slowly sprouts into fibrosis, which progresses to cirrhosis. Over a prolonged period of time compensated cirrhosis can advance to decompensated cirrhosis culminating in hepatic failure and death. Conventional treatment of HCV involves the administration of interferons. However, association of interferon with the adverse drug reactions led to the development of novel anti-HCV drugs given as monotherapy or in combination with the other drugs. Advances in drug delivery systems (DDS) improved the pharmacokinetic profile and stability of drugs, ameliorated tissue damages on extravasation and increased the targeting of affected sites. Liposomes and lipid based vehicles have been employed with polyethylene glycol (PEG) so as to stabilize the formulations as PEG drug complex. Sofosbuvir, a novel anti-HCV drug, is administered as monotherapy or in combination with daclatasvir, ledipasivir, protease inhibitors, ribavirin and interferon for the treatment of HCV genotypes 1, 2 and 3. These drug combinations are highly effective in eradicating the interferon resistance, recurrent HCV infection in liver transplant, concurrent HIV infection and preventing interferon related adverse effects. Further investigations to improve drug targeting and identification of new drug targets are highly warranted due to the rapid emergence of drug resistance in HCV

Psychological Morbidity in patients with Idiopathic Hirsutism presenting for Laser Treatment at a Tertiary Care Hospital

Objective: The objective of our study was to determine the frequency of depression, anxiety, and stress in females presenting for laser treatment of hirsutism at a dermatology clinic. Materials and Methods: This was a cross-sectional descriptive study. 152 female participants of all ages presenting for laser treatment of hirsutism to the dermatology department –removed for blind review--from June 2019 to Dec 2019, were included using a consecutive convenient sampling technique. Patients having an FG (Ferriman and Gallwey) score of 8 or more, were included whereas those having any underlying cause (as assessed by history and examination and laboratory investigations where required) for both hirsutism and psychological disorder were excluded. The participants were given an Urdu version of the DASS 21 (depression, anxiety, and stress scale) to complete. Results: The participants had a mean age of 30.22 (SD = 9.17). The prevalence of depression, anxiety, and stress in the sample was found to be 13.2%, 23.7%, and 17.8%, respectively. Mean depression, anxiety, and stress scores on DASS 21 were 4.43(SD=4.87, Cut-off= 10), 4.34(SD=5.12, Cut-off= 8), and 8.21(SD=6.26, Cut-off=15), respectively, indicating that the scores were within the normal range. Anxiety was the most common illness in the sample and both depression and stress showed a decline with advancing age up till 45years of age. No statistically significant association was found between the severity of hirsutism and depression, stress, and anxiety scores. Conclusion: Psychological morbidity was found to be lower in patients of idiopathic hirsutism presenting for laser treatment. The long-term efficacy of laser treatment needs further evaluation in future research

Ziziphus mauritiana leaf extract emulsion for skin rejuvenation

Purpose: To formulate stable water in oil (W/O) emulsion containing hydroalcoholic crude extract of Ziziphus mauritiana leaves for skin rejuvenation.Methods: Placebo (base) without any plant extract and formulation with 4 % Ziziphus mauritiana extract were prepared by mixing. Samples of the emulsions were subjected to varying storage conditions, i.e., 8, 25, 40 oC and 40 oC + 75 % relative humidity for a period of 4 weeks to predict their stability. During this period, stability parameters, including liquefaction, phase separation, color, electrical conductivity, centrifugation and pH were monitored at specified time intervals. Skin rejuvenation was evaluated using 13 healthy human volunteers over a period of 8 weeks. During this period, various skin parameters such as erythema, melanin level, moisture content, elasticity and sebum content of the skin were evaluated at specified intervals.Results: Both the active formulation and placebo were stable in terms of liquifaction, phase separation and color at all the storage conditions of temperature and humidity. Active formulation showed statistically significant (p < 0.05) improvement in skin melanin as well as in skin moisture and sebum levels, whereas these properties were reduced or even absent in the placebo formulation (p > 0.05). Both active and placebo formulations changed skin elasticity and erythema significantly (p < 0.05).Conclusion: İt is evident from the findings that the leaf extract of Ziziphus mauritiana possesses antiaging properties as well as exert skin lightening, moisturizing and viscoelastic effects on human skin.Keywords: Ziziphus mauritiana, Melanin, Erythema, Sebum, Skin-tlightening, Moistirizing, Anti-agin

The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population

Contains fulltext : 88996.pdf (publisher's version ) (Open Access)PURPOSE: The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients. METHODS: Multiplex polymerase chain reaction was used to study the GSTT1 and GSTM1 polymorphisms in 165 PEXG patients and 162 unaffected controls. RESULTS: In the current study we describe a significant gender-specific association of GSTT1 and GSTM1 null genotypes with PEXG. The three null genotype combinations (i.e., T1M0, T0M1, and T0M0) were found at significantly higher frequencies in the PEXG patients as compared to the controls (chi(2)=21.82, p0.05). CONCLUSIONS: The results suggest that there is a significant involvement of the GSTT1 and GSTM1 polymorphisms in female Pakistani patients having PEXG, which suggests a possible gender-specific impairment of detoxification in this group

Genotoxic and cytotoxic potential of whole plant extracts of Kalanchoe laciniata by Ames and MTT assay

Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic potential using Ames assay and cytotoxicity was evaluated using MTT assay. Ames assay was conducted using two strains of Salmonella typhimurium TA-100 and TA-102 whereas MTT assay was performed on baby hamster kidney cell line BHK-21. Aqua-methanolic extract of K. laciniata exhibited significant mutagenicity when exposed to TA- 102 strain with a mutagenic index of 50.66 and 54.74 at maximum dose 150 mg/plate. The extract was also muta- genic to TA-100 strain but to a lesser extent. M.I of n-hexane extract was 12.15 and 15.51 for TA-100 and TA- 102 respectively. n-hexane extract was mutagenic but little difference was observed between results of two strains. Both extracts were found to be cytotoxic with an IC50 of 321.9 and 638.5 µg/mL for aqua-methanolic and n-hexane extracts respectively. On the basis of results it was concluded that aqua-methanolic and n-hexane extracts of K. mutagenic and cytotoxic potential. It is suggested to explore the plant further to evaluate its safety in rodents and other species

Design Techniques in Rock and Soil Engineering

At the initial stage of tunnel design, the tunnel stability can be assessed by different design techniques which are broadly classified into three categories i.e. Mathematical Analysis, Empirical Methods and Numerical Analysis. Mathematical methods or closed form solutions are more precise methods; however, its use is limited to simple geometries and almost impossible for complex geometries due to complex and tedious calculations involved. In practice, Empirical and Numerical Methods are usually used for stability analysis of tunnels. It should be noted that it is not the replacement of final design. Empirical design methods use information about the structural geology and other rock mass properties as input that can be easily obtained at the initial stage of a project. Numerical Methods commonly require mechanical properties, especially strength and deformation of rocks. Numerical methods are also considered as precise due to provision of allowance for variable inputs and geometry and having ability for sensitivity analysis. It is good practice to evaluate the stability of tunnels using at least two Empirical methods and validated through Numerical methods