STATE REGULATION OF THE YOUTH AND CHILDREN TOURISM DEVELOPMENT IN UKRAINE

The problems of the state regulation of the youth and children tourism development in Ukraine were analysed in the article

ОСОБЕННОСТИ ПРОВЕДЕНИЯ РЕКЛАМНОЙ КАМПАНИИ В ТУРИСТИЧЕСКОЙ СФЕРЕ

Scientific and methodological approaches to developing an advertising campaign for a travel company were developed in the article. It is proved that the development of the tourist sector has relation-ship with the use of marketing communication channels, such as advertising. Advantages and disadvantages of advertising media in tourism are highlighted based on the analysis and synthesis of literature. Stepwise refinement of the process of the advertising campaign the company tourism sector as proposed by the authors.В статье получили дальнейшее развитие научно–методические подходы разработки рекламной кампании туристической фирмы. Обосновано, что развитие туристической сферы в определенной степени связано с использованием маркетинговых каналов коммуникации, в частности, рекламы. На основе анализа и обобщения литературы выделены преимущества и недостатки средств распространения рекламы в туризме. Авторами также предложена пошаговая детализация процесса проведения рекламной кампании предприятия туристической сферы

Features of the Advertising Campaign in the Tourist Sphere

В статье получили дальнейшее развитие научно–методические подходы разработки рекламной кампании туристической фирмы. Обосновано, что развитие туристической сферы в определенной степени связано с использованием маркетинговых каналов коммуникации, в частности, рекламы. На основе анализа и обобщения литературы выделены преимущества и недостатки средств распространения рекламы в туризме. Авторами также предложена пошаговая детализация процесса проведения рекламной кампании предприятия туристической сферы.Scientific and methodological approaches to developing an advertising campaign for a travel company were developed in the article. It is proved that the development of the tourist sector has relationship with the use of marketing communication channels, such as advertising. Advantages and disadvantages of advertising media in tourism are highlighted based on the analysis and synthesis of literature. Stepwise refinement of the process of the advertising campaign the company tourism sector as proposed by the authors

ADAPTIVE AGRO-TECHNOLOGY OF FARMING NEW WINTER WHEAT VARIETY IN THE TERSKO-SULAK TERRITORY

Aim. The aim of the research was to improve the elements of agro-technology for cultivating new high-yielding varieties of winter wheat under conditions of the plain zone irrigation depending on the doses and the terms of introducing mineral nitrogen-phosphorus fertilizers.Methods. Research was carried out on chestnut heavy loamy soils. Sampling of soils and plants, as well as agrochemical properties of soils were determined according to standard generally accepted methods. Mathematical processing of data on the yield of cereals was carried out by analysis-of-variance method using computer technology.Results. Our studies showed that the most productive of the studied varieties was Grom, which, on average for three years (2012-2015) gave a grain yield of 7.6 t/ha with nitrogen-phosphorus fertilizers introduced at a dose of N180P100 against 5.6 t/ha in a similar version to the control during sowing of the Tanya variety. Vassa and Sila varieties were also inferior to Grom variety for yields, respectively, by 1.1 t/ha and 1.4 t / ha. It was also revealed that with the Grom variety, when applying an increased dose of mineral fertilizers (N180P100), on average for three years, the best indicators were by the area of the leaf surface (63.6 thousand m2/ha), photosynthetic index of crops was 2765.6 thousand m2/ha and net productivity of photosynthesis was 6.3 g/m2, day. For other varieties of winter wheat and doses of mineral fertilizers, these indicators were lower.Conclusion. In steady-state experiment, when studying the potential of new high-yielding varieties of winter wheat at different levels and times of introducing mineral nutrition, the Grom variety showed the best yields

Giant Anharmonic Phonon Scattering in PbTe

Understanding the microscopic processes affecting the bulk thermal conductivity is crucial to develop more efficient thermoelectric materials. PbTe is currently one of the leading thermoelectric materials, largely thanks to its low thermal conductivity. However, the origin of this low thermal conductivity in a simple rocksalt structure has so far been elusive. Using a combination of inelastic neutron scattering measurements and first-principles computations of the phonons, we identify a strong anharmonic coupling between the ferroelectric transverse optic (TO) mode and the longitudinal acoustic (LA) modes in PbTe. This interaction extends over a large portion of reciprocal space, and directly affects the heat-carrying LA phonons. The LA-TO anharmonic coupling is likely to play a central role in explaining the low thermal conductivity of PbTe. The present results provide a microscopic picture of why many good thermoelectric materials are found near a lattice instability of the ferroelectric type

Twenty-year clinical progression of dysferlinopathy in patients from Dagestan

© 2017 Umakhanova, Bardakov, Mavlikeev, Chernova, Magomedova, Akhmedova, Yakovlev, Dalgatov, Fedotov, Isaev and Deev.To date, over 30 genes with mutations causing limb-girdle muscle dystrophy have been described. Dysferlinopathies are a form of limb-girdle muscle dystrophy type 2B with an incidence ranging from 1:1,300 to 1:200,000 in different populations. In 1996, Dr. S. N. Illarioshkin described a family from the Botlikhsky district of Dagestan, where limb-girdle muscle dystrophy type 2B and Miyoshi myopathy were diagnosed in 12 members from three generations of a large Avar family. In 2000, a previously undescribed mutation in the DYSF gene (c.TG573/574AT; p. Val67Asp) was detected in the affected members of this family. Twenty years later, in this work, we re-examine five known and seven newly affected family members previously diagnosed with dysferlinopathy. We observed disease progression in family members who were previously diagnosed and noted obvious clinical polymorphism of the disease. A typical clinical case is provided

Corrigendum: Twenty-year clinical progression of dysferlinopathy in patients from Dagestan [Front Neurol, 8, (2017) (77)] doi: 10.3389/fneur.2017.00077

The "Funding" section should be: This work was funded by Human Stem Cells Institute PJSC and Roman V. Deev. Theoretical part of this work was supported by Russian Scientific Foundation grant (14-15-00916). Ivan A. Yakovlev and Mikhail O. Mavlikeev were supported by the Russian Government Program of Competitive Growth of Kazan Federal University. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way

Реализация фармацевтической разработки с применением многофакторного анализа многокритериальной оптимизации на примере этапа очистки гидросукцината олигогексаметиленгуанидина

Objectives. The study set out to use mathematical modeling, in particular the method of multifactorial analysis of multicriteria optimization (MAMO), in the development of a pharmaceutical product.Methods. After carrying out experimental tests based on the proposed algorithmic sequence, the obtained data were interpreted using MAMO.Results. The possibility of using MAMO to solve the applied problem of purifying oligohexamethyleneguanidine hydrosuccinate (OHMG-HS), considered as a pharmaceutical precursor for the creation of medicines, was demonstrated.Conclusions. The expediency of using the proposed algorithm as a tool for pharmaceutical development is substantiated by identifying dependencies of the influence of purification conditions on the final content of admixtures in the target product.Цели. Данное исследование посвящено использованию математического моделирования, в частности метода многофакторного анализа многокритериальной оптимизации (МАМО), в фармацевтической разработке.Методы. В ходе исследования была предложена алгоритмическая последовательность эксперимента и проведены необходимые испытания. Полученные данные были интерпретированы при помощи МАМО.Результаты. Изучена возможность применения МАМО для решения прикладной проблемы очистки гидросукцината олигогексаметиленгуанидина (ОГМГ-ГС), рассматриваемого в качестве фармацевтической субстанции для создания лекарственных средств.Выводы. Были выявлены зависимости влияния условий очистки на конечное содержание примесей в целевом продукте и доказана целесообразность использования предложенного алгоритма в качестве инструмента фармацевтической разработки

Применение микрофлюидного аппаратного оснащения в синтезе производных олигогексаметиленгуанидина

Objectives. To develop a method for the microfluidic synthesis of oligohexamethylene guanidine salts in a flow-type reactor and to evaluate its effectiveness in relation to the synthesis in a traditional capacitive reactor and compare the purities of products obtained by these methods.Methods. The synthesis of oligohexamethylene guanidine bihydrocarbonate (OHMG-BHC) was done using microfluidic hardware and the classical approach in volume. The purity and structure of the resulting product were confirmed by 13C NMR spectroscopy and high-performance liquid chromatography (HPLC).Results. The 13C NMR spectrum of OHMG-BHC in classical bulk synthesis demonstrates that the product is unbranched and contains additionally unidentifiable impurities, in contrast to the sample obtained by the microfluidic method. Furthermore, the HPLC analysis showed that the OHMG-BHC sample synthesized using microfluidic technology has a 1.5-fold lower content than the initial monomers.Conclusions. The advantage of synthesizing OHMG-BHC in a flow-type reactor compared to the traditional method of synthesis in volume is demonstrated since a product with a higher degree of purity is obtained.Цели. Разработать методику микрофлюидного синтеза солей олигогексаметиленгуанидина в реакторе проточного типа и оценить ее эффективность по сравнению с синтезом в классическом емкостном реакторе, а также сравнить чистоту продуктов, полученных данными методами.Методы. Синтез олигогексаметиленгуанидина дигидрокарбоната (ОГМГ-ДГК) проводили с применением микрофлюидного аппаратного оснащения и классическим методом в объеме. Подтверждение чистоты и структуры полученного продукта осуществляли с помощью 13C ЯМР спектроскопии и высокоэффективной жидкостной хроматографии (ВЭЖХ).Результаты. Спектр 13C ЯМР ОГМГ-ДГК при классическом синтезе в объеме демонстрирует, что продукт является неразветвленным и содержит дополнительно неидентифицируемые примеси в отличие от образца, полученного микрофлюидным способом. Анализ методом ВЭЖХ показал, что образец ОГМГ-ДГК, синтезированный с помощью микрофлюидной технологии, имеет в 1.5 раза более низкое содержание исходных мономеров.Выводы. Синтез ОГМГ-ДГК в проточном реакторе имеет преимущество по сравнению с классическим способом синтеза в объеме, поскольку выдает продукт с более высокой степенью чистоты