Analyzing the Effects of Inventory Cost Setting Rules in a Disassembly and Recovery Environment

We consider a salvaging facility that satisfies the demand for remanufactured parts that can be recovered from the end-of-life products. One of the difficulties faced in planning for such a system is the determination of the opportunity cost associated with carrying recovered parts inventory. In this study we investigate the effect of different rules to determine this opportunity cost on the performance of the system. The performance of several different rules is assessed by a computational study under a proposed approximate inventory control policy

Analyzing the effects of inventory cost setting rules in a disassembly and recovery environment

In this study we consider a disassembly and recovery facility receiving end-of-life products and facing demand for a specific part that is disassembled from the product and then recovered. The disassembly and recovery operations can be either performed before hand, or upon customer arrival. In the latter case, a discount on the selling price is applied to compensate the customer for waiting for the completion of the disassembly and recovery operations. One of the dificulties faced in planning for such a system is the determination of the opportunity cost associated with carrying recovered parts inventory. The dificulty arises in seeking the value added to the part given the costs incurred for maintaining the product return, disassembly and recovery costs and revenue earned from the hulk, that is the remaining product after the disassembly of the part. The main objective of the study is to investigate the effect of different rules to determine this opportunity cost on the performance of the system. Six rules are considered in the study. The performance of the rules is assessed by a computational study under an approximate inventory control policy

Periodontal condition of patients with Thalassemia Major: A systematic review and meta-analysis

Objectives: The aim of this systematic review was to evaluate the existing evidence on the association between Thalassemia major (TM) and periodontal condition

Disassembly and Recovery Planning for a Salvaging Facility

Stochastic inventory models are investigated for a salvaging facility that disassembles a type of end-of-life product for recovery. A single-period newsvendor type of setting is considered to capture the basic tradeoffs between unit cost and revenue structures under three different product structure and recovery operation schemes. A numerical study is conducted to analyze the effects of dependencies due to product and recovery operation structures

Part Recovery under Quality and Demand Uncertainty with Environmental Costs

We consider acquisition and stocking decisions, motivated by the operations of a salvaging facility that collects a particular end-of-life product, performs a series of disassembly and recovery operations to reclaim a reusable part and sells the recovered part in the used parts market. We model uncertainties in demand and quality classification of the parts and include environmental fees that create a non-negligible tradeoff against the operational costs in acquisition and stocking decisions

Disseminated Aspergillosis due to Aspergillus niger in Immunocompetent Patient: A Case Report

Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised patients. Many cases of pulmonary, cutaneous, cerebral, and paranasal sinus aspergillosis in immunocompetent patient were defined in literature but disseminated aspergillosis is very rare. Here we present an immunocompetent case with extrapulmonary disseminated aspergillosis due to Aspergillus niger, totally recovered after effective antifungal treatment with voriconazole

Rapid differentiation of MSC into adipocytes and osteocytes is facilitated by Toll-Like receptor engagement

Mesenchymal stem cells are multipotent progenitor cells capable of differentiating into several lineages including adipocytes, and osteocytes. While they are regarded as non-immunogenic, accumulating evidence suggests that MSC expresses several TLRs. We checked the contribution of TLR ligands to MSC differentiation. Rat bone marrow derived MSC surface marker and TLR transcript levels were checked by FACS and RT-PCR respectively. MSCs were CD29hi, CD71dim, CD90hi, and negative for CD45 & CD34. They expressed TLR1,2,3,4,6, and low levels of 7 and 9 (no TLR5 was detected) at passage zero. Cells were incubated in adipogenic and osteogenic differentiation media either alone or supplemented with, TLR2L:PGN, TLR3L:pI:C, TLR7L:R848, and TLR9L:CpGODN as well as control ODN and followed for three weeks. Oil Red O staining (to assess adipogenesis) suggested that, induction in adipogenic media (by one week) gave no adipose positive cells whereas treatment with R848 or PGN induced significantly high adipose positive cells (1-2% vs 30-35%, respectively). The degree of adipogenic differentiation at wk1, was; TLR7≥TLR2>TLR3>TLR9>Control group≥medium. During osteogenesis (checked by alizarin red staining) by one week the highest differentiation was seen with CpG ODN treatment (TLR9≥TLR7>TLR2>TLR3>Control≥medium). These results strongly support the view that TLR ligands differentially contribute to transition of MSCs into either adipogenic or osteogenic differentiation

A dual role of proton pump inhibition on cancer: a critical review

Proton pump inhibitors (PPIs) are widely used to suppress gastric acid secretion. Proton pumps belong to the family of ATPase and among them P-ATPase and V-ATPase types regulate intracellular as well as extracellular acid equilibrium. The main aim of the current survey is to present the existing literature putting forth the relation between cancer with both the use of PPIs and proton pumps from positive and negative aspects. To perform an objective study, various types of proton pumps and their relation to cancer have been taken into account. Up to date, the studies have been considered in the time range from 2011 to 2021 via various databases (PubMed, Scopus, and Google Scholar). H+/K+ ATPase, located within the gastric parietal cells, is one of the most important examples of P-ATPases. The findings of the literature review along with criticism were presented as decreased P-ATPase expression can be used as a marker for gastric cancer diagnosis whereas the association of the proton pump with cancer may be mainly due to V-ATPase. In conclusion, molecular, epidemiological, and bioinformatic studies are required to enlighten the subject