Application of the resonant recognition model to analysis of interaction between viral and tumor suppressor proteins

Recent findings in cancer research has established a connection between a T-antigen - common virus - and a brain tumor in children. The studies suggested the T-antigen, the viral component of a specific virus, called the JC virus, plays a significant role in the development of the most frequent type of malignant brain tumors by blocking the functionality of tumor suppressor proteins such as p53 and pRb. Here we have investigated the structure and function relationships of T-antigen, p53 and pRb proteins using the Resonant Recognition Model (RRM), a physico-mathematical approach based on digital signal processing methods

Whispering Gallery Mode Dielectric Resonators for the Millimeter Wave Near Field Sensing Applications

The resonance characteristics of whispering gallery modes (WGMs) in parallel-plate type cylindrical dielectric resonators (DRs) are numerically considered to optimise their characteristics for sensing applications. Results for the dependency of the resonant frequency, Q-factor, slow-down factor and electric energy filling factor of the modes on resonator parameters for both isotropic and anisotropic DR are presented. The possible applications of the results for millimeter wave near field nondestructive measurements are discussed

Dual -1 Hahn polynomials and perfect state transfer

We find all the $XX$ spin chains with perfect state transfer (PST) that are connected with the dual -1 Hahn polynomials $R_n(x; \alpha,\beta,N)$. For $N$ odd we recover a model that had already been identified while for $N$ even, we obtain a new system exhibiting PST.Comment: 11 page

Numerical Modelling of Whispering Gallery Modes in Parallel-plates Type Cylindrical Anisotropic Dielectric Resonators

A parallel-plates-type cylindrical anisotropic dielectric resonator (DR) with whispering gallery modes (WGMs) has been investigated. Numerical modelling of the resonance frequencies, Q-factors and the electric field filling factors of the isotropic and anisotropic DR are presented. Applications of the results for sensing purposes are discussed

Investigation of the structural and functional relationships of oneogene proteins

Proteins are the biomolecular workhorses driving the most biological processes in any living organism. These processes are based on selective interactions between particular proteins. So far, the rules governing the coding of the protein's biological function, i.e. its ability to selectively interact with other biomolecules, have not been elucidated. The resonant recognition model (RRM) is a novel physicomathematical approach established to analyze the interaction between a protein and its target. The RRM assumes that the specificities of protein interactions are based on the resonant electromagnetic energy transfer at the specific frequency for each interaction. One of the main applications of this model is to predict the location of a protein's biological active site(s) using digital signal processing. This paper incorporates the continuous wavelet transform (CWT) into the RRM to predict the active sites, for a chosen protein example. We have investigated the oncogene functional group using digital signal analysis methods, in particular Fourier transform and CWT; determined oncogenes' characteristic frequency and functional active sites; and performed the design of the peptide analogous. The results obtained provide new insights into the structure-function relationships of the analyzed oncogene protein family

Airborne Pathogens Transport in an Aircraft Cabin

Airborne pathogens can spread within an aircraft cabin from sneezing, coughing or breathing of a sick passenger. This paper reports a 3D numerical study on the transport of airborne pathogens inside Boeing 767 cabin. After cough or sneeze of an infected passenger, the entire unsteady pathogen dispersion process is simulated. Effects under study include the direction of coughing on the pathogens propagation and the spreading times from infected to hosts passengers

Energy sinks: vibration absorption by an optimal set of undamped oscillators

This paper describes a new concept referred to here as “energy sinks” as an alternative to conventional methods of vibration absorption and damping. A prototypical energy sink envisioned here consists of a set of oscillators attached to, or an integral part of, a vibrating structure. The oscillators that make up an energy sink absorb vibratory energy from a structure and retain it in their phase space. In principle, energy sinks do not dissipate vibratory energy as heat in the classical sense. The absorbed energy remains in an energy sink permanently (or for sufficiently long durations) so that the flow of energy from the primary structure appears to it as damping. This paper demonstrates that a set of linear oscillators can collectively absorb and retain vibratory energy with near irreversibility when they have a particular distribution of natural frequencies. The approach to obtain such a frequency distribution is based on an optimization that minimizes the energy retained by the structure as a function of frequency distribution of the oscillators in the set. The paper offers verification of such optimal frequency spectra with numerical simulations and physical demonstrations