A Comparison of the LVDP and {\Lambda}CDM Cosmological Models

We compare the cosmological kinematics obtained via our law of linearly varying deceleration parameter (LVDP) with the kinematics obtained in the {\Lambda}CDM model. We show that the LVDP model is almost indistinguishable from the {\Lambda}CDM model up to the near future of our universe as far as the current observations are concerned, though their predictions differ tremendously into the far future.Comment: 6 pages, 5 figures, 1 table, matches the version to be published in International Journal of Theoretical Physic

Some FRW Models of Accelerating Universe with Dark Energy

The paper deals with a spatially homogeneous and isotropic FRW space-time filled with perfect fluid and dark energy components. The two sources are assumed to interact minimally, and therefore their energy momentum tensors are conserved separately. A special law of variation for the Hubble parameter proposed by Berman (1983) has been utilized to solve the field equations. The Berman's law yields two explicit forms of the scale factor governing the FRW space-time and constant values of deceleration parameter. The role of dark energy with variable equation of state parameter has been studied in detail in the evolution of FRW universe. It has been found that dark energy dominates the universe at the present epoch, which is consistent with the observations. The physical behavior of the universe is discussed in detail.Comment: 10 pages, 5 figure

Cosmological models with linearly varying deceleration parameter

We propose a new law for the deceleration parameter that varies linearly with time and covers Berman's law where it is constant. Our law not only allows one to generalize many exact solutions that were obtained assuming constant deceleration parameter, but also gives a better fit with data (from SNIa, BAO and CMB), particularly concerning the late time behavior of the universe. According to our law only the spatially closed and flat universes are allowed; in both cases the cosmological fluid we obtain exhibits quintom like behavior and the universe ends with a big-rip. This is a result consistent with recent cosmological observations.Comment: 12 pages, 7 figures; some typo corrections; to appear in International Journal of Theoretical Physic

Bianchi type II models in the presence of perfect fluid and anisotropic dark energy

Spatially homogeneous but totally anisotropic and non-flat Bianchi type II cosmological model has been studied in general relativity in the presence of two minimally interacting fluids; a perfect fluid as the matter fluid and a hypothetical anisotropic fluid as the dark energy fluid. The Einstein's field equations have been solved by applying two kinematical ans\"{a}tze: we have assumed the variation law for the mean Hubble parameter that yields a constant value of deceleration parameter, and one of the components of the shear tensor has been considered proportional to the mean Hubble parameter. We have particularly dwelled on the accelerating models with non-divergent expansion anisotropy as the Universe evolves. Yielding anisotropic pressure, the fluid we consider in the context of dark energy, can produce results that can be produced in the presence of isotropic fluid in accordance with the \Lambda CDM cosmology. However, the derived model gives additional opportunities by being able to allow kinematics that cannot be produced in the presence of fluids that yield only isotropic pressure. We have obtained well behaving cases where the anisotropy of the expansion and the anisotropy of the fluid converge to finite values (include zero) in the late Universe. We have also showed that although the metric we consider is totally anisotropic, the anisotropy of the dark energy is constrained to be axially symmetric, as long as the overall energy momentum tensor possesses zero shear stress.Comment: 15 pages; 5 figures; matches the version published in The European Physical Journal Plu

Multifunctional Adaptive NS1 Mutations Are Selected upon Human Influenza Virus Evolution in the Mouse

The role of the NS1 protein in modulating influenza A virulence and host range was assessed by adapting A/Hong Kong/1/1968 (H3N2) (HK-wt) to increased virulence in the mouse. Sequencing the NS genome segment of mouse-adapted variants revealed 11 mutations in the NS1 gene and 4 in the overlapping NEP gene. Using the HK-wt virus and reverse genetics to incorporate mutant NS gene segments, we demonstrated that all NS1 mutations were adaptive and enhanced virus replication (up to 100 fold) in mouse cells and/or lungs. All but one NS1 mutant was associated with increased virulence measured by survival and weight loss in the mouse. Ten of twelve NS1 mutants significantly enhanced IFN-β antagonism to reduce the level of IFN β production relative to HK-wt in infected mouse lungs at 1 day post infection, where 9 mutants induced viral yields in the lung that were equivalent to or significantly greater than HK-wt (up to 16 fold increase). Eight of 12 NS1 mutants had reduced or lost the ability to bind the 30 kDa cleavage and polyadenylation specificity factor (CPSF30) thus demonstrating a lack of correlation with reduced IFN β production. Mutant NS1 genes resulted in increased viral mRNA transcription (10 of 12 mutants), and protein production (6 of 12 mutants) in mouse cells. Increased transcription activity was demonstrated in the influenza mini-genome assay for 7 of 11 NS1 mutants. Although we have shown gain-of-function properties for all mutant NS genes, the contribution of the NEP mutations to phenotypic changes remains to be assessed. This study demonstrates that NS1 is a multifunctional virulence factor subject to adaptive evolution

Evaluation and Treatment of Iron Deficiency Anemia: A Gastroenterological Perspective

A substantial volume of the consultations requested of gastroenterologists are directed towards the evaluation of anemia. Since iron deficiency anemia often arises from bleeding gastrointestinal lesions, many of which are malignant, establishment of a firm diagnosis usually obligates an endoscopic evaluation. Although the laboratory tests used to make the diagnosis have not changed in many decades, their interpretation has, and this is possibly due to the availability of extensive testing in key populations. We provide data supporting the use of the serum ferritin as the sole useful measure of iron stores, setting the lower limit at 100 μg/l for some populations in order to increase the sensitivity of the test. Trends of the commonly obtained red cell indices, mean corpuscular volume, and the red cell distribution width can provide valuable diagnostic information. Once the diagnosis is established, upper and lower gastrointestinal endoscopy is usually indicated. Nevertheless, in many cases a gastrointestinal source is not found after routine evaluation. Additional studies, including repeat upper and lower endoscopy and often investigation of the small intestine may thus be required. Although oral iron is inexpensive and usually effective, there are many gastrointestinal conditions that warrant treatment of iron deficiency with intravenous iron