2 research outputs found
Isotropic singularity in inhomogeneous brane cosmological models
We discuss the asymptotic dynamical evolution of spatially inhomogeneous
brane-world cosmological models close to the initial singularity. By
introducing suitable scale-invariant dependent variables and a suitable gauge,
we write the evolution equations of the spatially inhomogeneous brane
cosmological models with one spatial degree of freedom as a system of
autonomous first-order partial differential equations. We study the system
numerically, and we find that there always exists an initial singularity, which
is characterized by the fact that spatial derivatives are dynamically
negligible. More importantly, from the numerical analysis we conclude that
there is an initial isotropic singularity in all of these spatially
inhomogeneous brane cosmologies for a range of parameter values which include
the physically important cases of radiation and a scalar field source. The
numerical results are supported by a qualitative dynamical analysis and a
calculation of the past asymptotic decay rates. Although the analysis is local
in nature, the numerics indicates that the singularity is isotropic for all
relevant initial conditions. Therefore this analysis, and a preliminary
investigation of general inhomogeneous () models, indicates that it is
plausible that the initial singularity is isotropic in spatially inhomogeneous
brane-world cosmological models and consequently that brane cosmology naturally
gives rise to a set of initial data that provide the conditions for inflation
to subsequently take place.Comment: 32 pages with 8 pictures. submitted to Class. Quant. Gra
Computational applications in secondary metabolite discovery (caismd): An online workshop
We report the major conclusions of the online open-access workshop “Computational Applications in Secondary
Metabolite Discovery (CAiSMD)” that took place from 08 to 10 March 2021. Invited speakers from academia and
industry and about 200 registered participants from fve continents (Africa, Asia, Europe, South America, and North
America) took part in the workshop. The workshop highlighted the potential applications of computational meth‑
odologies in the search for secondary metabolites (SMs) or natural products (NPs) as potential drugs and drug leads.
During 3 days, the participants of this online workshop received an overview of modern computer-based approaches
for exploring NP discovery in the “omics” age. The invited experts gave keynote lectures, trained participants in handson sessions, and held round table discussions. This was followed by oral presentations with much interaction between
the speakers and the audience. Selected applicants (early-career scientists) were ofered the opportunity to give oral
presentations (15 min) and present posters in the form of fash presentations (5 min) upon submission of an abstract.
The fnal program available on the workshop website (https://caismd.indiayouth.info/) comprised of 4 keynote lec‑
tures (KLs), 12 oral presentations (OPs), 2 round table discussions (RTDs), and 5 hands-on sessions (HSs). This meeting
report also references internet resources for computational biology in the area of secondary metabolites that are of
use outside of the workshop areas and will constitute a long-term valuable source for the community. The workshop
concluded with an online survey form to be completed by speakers and participants for the goal of improving any
subsequent editions