QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS

We evaluated the quality of life (QOL) in 268 patients with diabetes mellitus (NIDDM, 250 cases; IDDM, 10 cases; and other type of diabetes, 8 cases) to determine which aspects were adversely affected by the disease. Information concerning life satisfaction, social activities, ability to work, sexual problems and physical symptoms was obtained from a 30-item questionnaire. Clinical characteristics including duration of diabetes, glycemic control, current treatment, obesity, hypertension, hyperlipidemia, macro- and microvascular complications were obtained from medical records. Diminished QOL was most pronounced in patients who had had a long duration of disease, required insulin therapy, and whose health was disturbed by cerebrovascular disease, end-stage renal disease, mono- and autonomic neuropathy. A significant difference in the subdimensional QOL score was noted in life satisfaction, social activities, ability to work, sexual problems and physical symptoms under these circumstances

CLINICAL CHARACTERISTICS OF ISCHEMIC STROKE IN PATIENTS WITH DIABETES MELLITUS

To investigate the clinical characteristics of ischemic stroke and its associa- tions with hypertension, obesity, hyperlipidemia, and diabetic microangiopathy in patients with diabetes mellitus, we estimated the average period between onset of diabetes and ischemic stroke, and the incidences of complications. A total of 544 patients with diabetes mellitus who were admitted to our hospital over the past 10 years were analyzed, forty of whom were diabetic patients who suffered ischemic stroke as diagnosed by clinical exami- nation. As controles, 40 subjects matched for sex, age, and duration of diabetes were identified, one for each patient with ischemic stroke. The average period between onset of diabetes and ischemic stroke was significantly shorter for patients with hypertension than for normotensive patients ; however, there were no differences in the length of this period between the groups with and without obesity or hyperlipidemia. Hypertension was present in 63% of patients with ischemic stroke, and the incidence of hypertension was significantly higher in the stroke group than in the control group. There was no difference between the groups with and without ischemic stroke with respect to the incidence of obesity, hyper- lipidemia, retinopathy and nephropathy. We conclude that diabetic patients with hyperten- sion appear to be at high risk for ischemic stroke

LIFESTYLE OF PATIENTS WITH DIABETES MELLITUS

We evaluated the lifestyle of 214 patients with diabetes mellitus to deter- mine which aspects were affected by their disease and diabetic complications. Information concerning lifestyle was obtained from 15-item questionnaires, and a total lifestyle score (TLS) was calculated. Clinical characteristics including duration of diabetes, glycemic control, current treatment, obesity, hypertension, hyperlipidemia, and macro- and microvas- cular complications were evaluated. Patients in their 40s had the lowest TLS, and lifestyle factors were strongly associated with glycemic control, ischemic heart disease, and with autonomic neuropathy. Subjects were also divided into two subgroups of equal size based on the median rate of TLS : an adequate lifestyle group and an inadequate lifestyle group. Although degree of excess in caloric intake was similar in these two groups, sodium intake was significantly higher in the inadequate lifestyle group than in the adequate lifestyle group

SMOKING HABIT AND PROGRESSION OF DIABETIC NEPHROPATHY

The effect of cigarette smoking on the progression of diabetic nephropathy was evaluated cross-sectionally in 155 patients with non-insulin-dependent diabetes mel- litus of at least 5 years duration. Forty-four patients had a smoking habit. There was no difference in the duration of diabetes, mean value of HbA1c, or the prevalence of hyperten- sion between the smokers and nonsmokers. However, there was a significant difference in the distribution of a smoking habit among subgroups of diabetic patients with normoal- buminuria, microalbuminuria, and overt proteinuria. Thus, cigarette smoking in patients with diabetes is concluded to be a risk factor for the development of diabetic nephropathy

ASSESSMENT OF BASILAR ARTERY HEMODYNAMICS IN TYPE 2 DIABETIC PATIENTS WITH NO HISTORY OF CEREBROVASCULAR DISEASE BY USING TRANSCRANIAL DOPPLER ULTRASOUND

We compared intracranial hemodynamics in 121 type 2 diabetic patients who had no history of cerebrovascular disease with findings in 123 matched control subjects. Mean blood flow velocity (MFV) and Fourier pulsatility index were determined by using transcranial Doppler ultrasonography (TCD). MFV in the basilar artery was significantly lower in diabetic than in nondiabetic subjects (p＜0.01), while Fourier PI of the basilar artery was significantly higher in diabetic than in nondiabetic subjects (p＜0.01). In multivariate regression analysis, increased Fourier PI and decreased MFV were associated with higher age, female gender, and longer duration of diabetes. Decreased MFV was also associated with microalbuminuria. These findings demonstrated deterioration of basilar artery hemodynamics in patients with type 2 diabetes who have no stroke history. Additionally, repeated TCD may prove to be useful for monitoring cerebrovascular impairments in these patients

Synthetic study of 13C labeled sialyl LeX mimetics

講演番号：3 A2-35 日本化学会第81春季年会, 平成14年3月26日～3月29日, 東

Study of efficient 13C labelling of Neu5Ac α (2→3)Gal

講演番号：3 G3 02 日本化学会第79春季年会, 平成12年3月28日～3月31日, 神