Quantum entanglement of charges in bound states with finite-size dyons

We show that the presence of finite-size monopoles can lead to a number of interesting physical processes involving quantum entanglement of charges. Taking as a model the classical solution of the N=2 SU(2) Yang-Mills theory, we study interaction between dyons and scalar particles in the adjoint and fundamental representation. We find that there are bound states of scalars and dyons, which, remarkably, are always an entangled configuration of the form |\psi > =|dyon+> |scalar-> +/- |dyon->|scalar+>. We determine the energy levels and the wave functions and also discuss their stability.Comment: 29 pages, 3 figures. Minor correction in references (to appear in JHEP04 (2002) 010

In vitro Anti Diabetic Potential of Loranthacean Hemi Parasite Helicantes elasticus Desv Danser Collected from Six Different Hosts

In vitro anti-diabetic potential of methanolic extract of Helicantheselasticus(Desv.) Danser growing on six different hosts and thereby comparing the host’s influence on this parasitic plant for this efficacy was studied and statistically analysed. The results showed that Hemiparasite collected from Heveabrasiliensis, Citrus maxima, Anacardiumoccidentale and Saracaasoca were found highly effective in this regard. Highest inhibition on α-amylase was shown by H.elasticuscollected from Heveabrasiliensis where as inhibition of α-glucosidase was found to be highest in hemiparasite obtained from Citrus maxima. The host plants selected under study was also found good in reducing the blood glucose level. The study clearly reveals the fact that, anti-diabetic potential of H.elasticus have significantly influenced by the host trees

Morphological and biochemical response to salinity stress on Setariaitalicaseedlings

Salinity is considered as the most important abiotic stress limiting the crop production.The present investigation was made to study the impact of different concentrations of sodium chloride on growth, biochemical constituents and antioxidant enzymes of the seedlings of Setaria italica. Seeds were grown at different concentrations of NaCl [(0,25,50,75, and 100mM] for twenty five days. Salt stress influenced a significant modification in the level of osmolyte accumulation.The accumulation level of osmolytes such as proline, glycine betaine,phenol and antioxidant enzyme such as catalase (CAT) and hydrogen peroxide increased significantly with increasing salt stress conditionwhen compared to the control. A statistically significant decreaseof seed germination percentage,root and shoot length,photosynthetic pigments like chlorophyll a, chlorophyll b and proteins when higher concentration of NaCl added were recorded. From this experiment it was found that the foxtail millet crops can be sustained in optimum (75 mM) salinity condition. It was concluded that these osmolytes play a key role in generating tolerance against salt stress

Implementing and Characterizing Real-time Broadband RFI Excision for the GMRT Wideband Backend

The Giant Metrewave Radio Telescope (GMRT) is being upgraded to increase the receiver sensitivity. This makes the receiver more susceptible to man-made Radio Frequency Interference (RFI). To improve the receiver performance in presence of RFI, real-time RFI excision (filtering) is incorporated in the GMRT wideband backend (GWB). The RFI filtering system is implemented on FPGA and CPU-GPU platforms to detect and remove broadband and narrowband RFI. The RFI is detected using a threshold-based technique where the threshold is computed using Median Absolute Deviation (MAD) estimator. The filtering is carried out by replacing the RFI samples by either noise samples or constant value or threshold. This paper describes the status of the real-time broadband RFI excision system in the wideband receiver chain of the upgraded GMRT (uGMRT). The test methodology for carrying out various tests to demonstrate the performance of broadband RFI excision at the system level and on radio astronomical imaging experiments are also described.Comment: 7 pages, 7 figure

DEVELOPMENT OF ANALYTICAL METHOD FOR IMATINIB MESYLATE BY ULTRAVIOLET SPECTROSCOPY

Objective: A simple, selective, sensitive, specific, and spectrophotometric method has been developed for the detection of imatinib mesylate in pure form and formulations. Methods: The analytical condition was optimized for the drug, carried out as per the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines. Results: The drug shows absorption at 232.0 nm and obeyed beers law in the wide concentration range from 0.5 to 4.0 μg/ml. The lower limit of detection was found to be 0.331 μg/ml and the limit of quantification to be 1.004 μg/ml. The regression equation was found to be y = 0.08x. The precision of the method was found to be 99.04%±0.527% and the percentage of drug recovered by this method is 100.13%±1.375%. Conclusion: The method is simple and suitable for determination for imatinib mesylate in pure and pharmaceutical preparation

DEVELOPMENT AND VALIDATION OF A MODIFIED POLARIMETRIC ASSAY METHOD FOR SMALL VOLUME SAMPLES

Objective: The objective of the present work was to develop a method to be useful for analyzing small volume samples of an optically active compound.Methods: The method employed quartz cuvette instead of a polarimeter tube. Quantification of optically active compound was successfully validated in terms of linearity and range, precision and robustness. The detection limit (DL) and quantitation limit (QL) were determined as per the ICH guidelines.Results: Polarimetry generally involves the quantification of optically active compounds by measuring its ability to rotate (in terms of angle of rotation) polarized light passed through it. The plot of angle of rotation versus concentration was linear in wide range of concentration with excellent coefficient of determination of 0.9989±0.0008. The low values of % relative standard deviation (RSD) for repeatability and intermediate precision suggested an excellent precision of the developed polarimetric method. The detection limit (DL) and quantitation limit (QL) were determined were found to be 0.5025 and 1.5225 %w/v respectively.Conclusion: A modified polarimetric method for the quantification of dextrose was successfully developed and validated. The method employed quartz cuvette instead of polarimeter tube. The method is expected to be useful in a variety of industries where dextrose finds its application. The method can also be extended to other optically active compounds

A PREFORMULATION STUDY ON INTERACTIONS BETWEEN DOXORUBICIN HYDROCHLORIDE AND BOVINE SERUM ALBUMIN

Objective: The objective was to study the effect of concentrations of doxorubicin hydrochloride (Dox) and bovine serum albumin (BSA) in a sample on fluorescence intensity, UV absorbance, refractive index and optical rotation.Methods: A circumscribed central composite statistical design with 2 factors, 5 levels, and 13 runs was selected for the study. According to that influence of both in interaction was measured by fluorescence intensity, UV absorbance, refractive index and optical rotation and were analyzed by the design expert software.Results: It was observed that concentration of BSA alone was significantly affecting the fluorescence intensity and optical rotation of samples. Dox alone was having a significant effect on UV absorbance at 280 nm. In the case of a refractive index, both Dox and BSA were having a significant effect. But the effect of BSA was much pronounced than that of Dox on refractive index.Conclusion: Interaction studies between BSA and Dox would be beneficial as they are commonly used in combination with tumor-targeted delivery. The interaction was observed that in a linear model for a wide range of concentration of both. So it will be useful to determine the interaction of unknown concentration

Targeted therapies in the management of colorectal carcinoma: role of bevacizumab

Colorectal cancer continues to be an important public health concern, despite improvements in screening and better systemic chemotherapy. The integration of targeted therapies in the treatment of colon cancer has resulted in significant improvements in efficacy outcomes. Angiogenesis is important for tumor growth and metastasis and is an important target for new biological agents. Bevacizumab is a humanized recombinant antibody that prevents vascular endothelial growth factor (VEGF) receptor binding, and inhibits angiogenesis and tumor growth. The addition of bevacizumab to fluoropyrimidine-based chemotherapy, with or without irinotecan or oxaliplatin, in both the first- and second-line treatment of metastatic colorectal cancer, significantly increased median progression-free survival and overall survival in select randomized phase III studies. Ongoing studies are evaluating the role of bevacizumab in the adjuvant treatment of colon cancer. Common toxicities associated with bevacizumab include hypertension, bleeding episodes, and thrombotic events. This review will focus on the integration of bevacizumab in the treatment paradigm of colon cancer and the management of its side effects

Correlation of wrist circumference with waist circumference and body mass index in adults with early-onset type 2 diabetes mellitus

Background: Recent studies have shown that wrist circumference is correlated with insulin resistance, obesity and new onset diabetes. Being easy to measure, it may be useful in identifying individuals at risk for cardio- metabolic disorders.Methods: 112 consecutive subjects with new onset type 2 diabetes in the age group 18-44 years were included in the study. Socio demographic characteristics, anthropometric and biochemical measurements were carried out using standard techniques. Pearson product movement Correlation Coefficient was used to find out correlation with other measures of obesity and ROC curve to determine its cut off values.Results: Wrist circumference showed moderate positive correlation with BMI (r+0.389) and waist circumference (r+0.443). The cut off value of wrist circumference when compared with BMI in defining obesity was 16.5cm in male and 15.7 cm in female. The cut off value of wrist circumference with waist circumference in male was 16.2cm.Conclusions: Measurement of wrist circumference may supplement in assessing obesity especially when other measures of obesity like BMI or Waist circumference measurements are difficult or not feasible

Clinical presentation and outcomes of solitary plasmacytoma in a tertiary hospital in the UK

Solitary plasmacytoma is a rare localised neoplasm of monoclonal plasma cells. The standard treatment involves radical radiotherapy; however, a significant proportion of patients subsequently develop multiple myeloma. In this study, we evaluate the outcomes of solitary plasmacytoma in a retrospective cohort of patients treated in a single tertiary centre.The case records of plasmacytoma patients treated in a 15-year period were analysed and retrospectively followed up from the date of diagnosis. Thirty-four cases met the inclusion criteria; 27 (79%) solitary plasmacytoma of bone (SBP) and 7 (21%) extramedullary plasmacytoma (EMP). The thoracic vertebrae were the commonest sites for SBP while EMP occurred most frequently in the upper airway. Pain and spinal cord compression were the most frequent symptoms. A paraprotein was detectable in 18 (53%) patients. Over a median follow-up of 48 months, 13 (38%) developed multiple myeloma. The 5- and 10-year survival rates were 80% and 56%, respectively; median progression-free survival was 77 months. Four patients (12%) developed a second malignancy.Progression to multiple myeloma remains a formidable challenge in the management of solitary plasmacytoma, hence adjunct therapies are needed