25 research outputs found

    Modeling causes of death: an integrated approach using CODEm

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    Background: Data on causes of death by age and sex are a critical input into health decision-making. Priority setting in public health should be informed not only by the current magnitude of health problems but by trends in them. However, cause of death data are often not available or are subject to substantial problems of comparability. We propose five general principles for cause of death model development, validation, and reporting.Methods: We detail a specific implementation of these principles that is embodied in an analytical tool - the Cause of Death Ensemble model (CODEm) - which explores a large variety of possible models to estimate trends in causes of death. Possible models are identified using a covariate selection algorithm that yields many plausible combinations of covariates, which are then run through four model classes. The model classes include mixed effects linear models and spatial-temporal Gaussian Process Regression models for cause fractions and death rates. All models for each cause of death are then assessed using out-of-sample predictive validity and combined into an ensemble with optimal out-of-sample predictive performance.Results: Ensemble models for cause of death estimation outperform any single component model in tests of root mean square error, frequency of predicting correct temporal trends, and achieving 95% coverage of the prediction interval. We present detailed results for CODEm applied to maternal mortality and summary results for several other causes of death, including cardiovascular disease and several cancers.Conclusions: CODEm produces better estimates of cause of death trends than previous methods and is less susceptible to bias in model specification. We demonstrate the utility of CODEm for the estimation of several major causes of death

    The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019

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    A framework for building efficient environmental permitting processes

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    Despite its importance as a tool for protecting air and water quality, and for mitigating impacts to protected species and ecosystems, the environmental permitting process is widely recognized to be inefficient and marked by delays. This article draws on a literature review and interviews with permitting practitioners to identify factors that contribute to delayed permit decisions. The sociopolitical context, projects that are complex or use novel technology, a fragmented and bureaucratic regulatory regime, serial permit applications and reviews, and applicant and permitting agency knowledge and resources each contribute to permitting inefficiency when they foster uncertainty, increase transaction costs, and allow divergent interests to multiply, yet remain unresolved. We then use the interviews to consider the potential of a collaborative dialogue between permitting agencies and applicants to mitigate these challenges, and argue that collaboration is well positioned to lessen permitting inefficiency

    Catchment Scale Simulations of Soil Moisture Dynamics Using an Equivalent Cross-Section based Hydrological Modelling Approach

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    Physically based distributed hydrological models are useful for simulating the spatial distribution of hydrologic fluxes across the catchment under various climate and land cover change scenarios. However, complexities associated with their implementation at large scales make their applications limited. Previously, an equivalent cross-section (ECS) based distributed hydrological modelling approach was developed for first order sub-basins to reduce the computational time/effort. Here, the ECS approach is modified for semi-distributed hydrological modelling at the catchment scale. The modelling approach is implemented for a 314 km2 McLaughlin catchment located in south-eastern New South Wales (NSW), Australia that consists of 822 first order sub-basins. A 26 year long streamflow record simulated using an ECS based modelling approach are compared against daily observed streamflow and four calibrated lumped conceptual hydrologic models, and found to be consistent. Further, the simulated actual evapotranspiration and soil moisture from the ECS approach are compared against the Australian Water Availability Project (AWAP) model simulations and results found to be consistent. In addition, the temporal dynamics of simulated soil moisture from the ECS approach is consistent with the satellite derived European Space Agency Climate Change Initiative (ESA CCI) surface soil moisture data. In the ECS based semi-distributed modelling, all parameters are derived from the actual topographic and physiographic information of the catchment and none of the parameters is calibrated. Therefore, this approach has the advantage of simulating streamflow in ungauged catchments compared to lumped conceptual models. The impact of spatially distributed climatic forcing and land cover on soil moisture is investigated across four landforms (upslope, midslope, footslope and alluvial-flats) and at various soil depths. Our results show increase of mean soil moisture in shallow layers of upslope toward alluvial-flats. However, mean soil moisture in deeper horizons remained almost constant across all landforms. The variability of daily soil moisture at surface soil layers is higher than the deeper soil layers for all landforms. Our results illustrated that disaggregation of a catchment to a series of ECS at the scale of first order sub-basins, captures dynamics of soil moisture and actual evapotranspiration across the landscape and results are consistent with the climatology, land cover type, topography and soil hydraulic properties. Further, the use of ECS approach in the McLaughlin catchment reduced the number of computational units by 40 times in comparison to 3-d grid based distributed modelling setup
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