11 research outputs found

    РасчСт Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΏΠΎΡ‚ΠΎΠΊΠ° Π² элСктроциклонС

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    To analyze the elektrocyclone flow hydrodynamic computer calculation using the finite element method (FEM) is applied. The geometry of the model corresponds to the laboratoryΒ Β elektrocyclone. k-Ξ΅-turbulence model is used for the computation. The system of equations is solved by SIMPLE algorithm. The calculation results give a pattern of the flow velocity distribution and flow lines in different sections. There is conclusion based on the results about elektrocyclone flow hydrodynamic.Для Π°Π½Π°Π»ΠΈΠ·Π° Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΏΠΎΡ‚ΠΎΠΊΠ° Π² элСктроциклонС ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½Ρ‹ΠΉ расчСт с использованиСм ΠΌΠ΅Ρ‚ΠΎΠ΄Π° ΠΊΠΎΠ½Π΅Ρ‡Π½Ρ‹Ρ… элСмСнтов (МКЭ). ГСомСтрия ΠΌΠΎΠ΄Π΅Π»ΠΈ соотвСтствуСт Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½ΠΎΠΌΡƒ элСктроциклону. Для расчСтов использована k-Ξ΅-модСль турбулСнтности. БистСма ΡƒΡ€Π°Π²Π½Π΅Π½ΠΈΠΉ Ρ€Π΅ΡˆΠ°Π΅Ρ‚ΡΡ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌΠ° SIMPLE. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ расчСта Π΄Π°ΡŽΡ‚ ΠΊΠ°Ρ€Ρ‚ΠΈΠ½Ρƒ распрСдСлСния скоростСй ΠΏΠΎΡ‚ΠΎΠΊΠ° ΠΈ Π»ΠΈΠ½ΠΈΠΉ Ρ‚ΠΎΠΊΠ° Π² Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… сСчСниях. На основании Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² дСлаСтся Π²Ρ‹Π²ΠΎΠ΄ ΠΎ Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ элСктроциклона. ВыявлСн Ρ„Π°ΠΊΡ‚, Ρ‡Ρ‚ΠΎ Π² Π±ΡƒΠ½ΠΊΠ΅Ρ€Π΅ элСктроциклона отсутствуСт Π²ΠΈΡ…Ρ€Π΅Π²ΠΎΠ΅ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠ΅, Ρ‚Π°ΠΊΠΆΠ΅ Π½Π΅Ρ‚ Ρ€Π°Π·Π²ΠΈΡ‚ΠΎΠ³ΠΎ тСчСния Π² области стСнок, Π° Π½ΠΈΠΆΠ΅ Π²Ρ‹Ρ…Π»ΠΎΠΏΠ½ΠΎΠ³ΠΎ отвСрстия ΡΠΊΠΎΡ€ΠΎΡΡ‚ΡŒ ΠΏΠΎΡ‚ΠΎΠΊΠ° Π±Π»ΠΈΠ·ΠΊΠ° ΠΊ 0. Π­Ρ‚ΠΎ благоприятно сказываСтся Π½Π° эффСктивности очистки, Ρ‚. ΠΊ. выходящий чистый Π³Π°Π· Π½Π΅ ΡƒΠ²Π»Π΅ΠΊΠ°Π΅Ρ‚ с собой осСвшиС частицы. Π’Ρ‹Π²ΠΎΠ΄Ρ‹: 1) Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° элСктроциклона ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ описана с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ матСматичСской ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈ рассчитана с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ МКЭ; 2) ΠΏΠΎΡ‚ΠΎΠΊ Π² элСктроциклонС, ΠΊΠ°ΠΊ ΠΈ оТидалось, ΠΈΠΌΠ΅Π΅Ρ‚ Π·Π°ΠΊΡ€ΡƒΡ‡Π΅Π½Π½ΡƒΡŽ структуру, ΡƒΠ³ΠΎΠ» Π·Π°ΠΊΡ€ΡƒΡ‚ΠΊΠΈ зависит ΠΎΡ‚ Π΄Π»ΠΈΠ½Ρ‹ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ Π·ΠΎΠ½Ρ‹; 3) конструкция Π±ΡƒΠ½ΠΊΠ΅Ρ€Π° обСспСчиваСт Π²Ρ‹Ρ…ΠΎΠ΄ ΠΎΡ‡ΠΈΡ‰Π΅Π½Π½ΠΎΠ³ΠΎ Π³Π°Π·Π° Π±Π΅Π· вовлСчСния Π² Π½Π΅Π³ΠΎ ΡƒΠ»ΠΎΠ²Π»Π΅Π½Π½Ρ‹Ρ… частиц

    THE RESEARCH RESULTS OF DEHYDRATION PROCESS OF GOSSYPOL RESIN

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    This article is focused on the results of dehydration process of the oil and fat waste products- gossypol. The research was held in the temperature interval from room temperature until 160 degrees Celsius while constant shufflin

    RESEARCHES OF PROCESS OF RECEPTION OF ANTICORROSIVE MATERIALS AND BUILDING BITUMENS ON THE BASIS OF GOSSIPOL RESIN

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    The article presents the results of research of technological processes of anticorrosive coatings and substitute petroleum bitumen based on gossipol resin from waste oil and fat plant

    Elektrocyclone hydrodynamic flow computation

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    Для Π°Π½Π°Π»ΠΈΠ·Π° Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΏΠΎΡ‚ΠΎΠΊΠ° Π² элСктроциклонС ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½Ρ‹ΠΉ расчСт с использованиСм ΠΌΠ΅Ρ‚ΠΎΠ΄Π° ΠΊΠΎΠ½Π΅Ρ‡Π½Ρ‹Ρ… элСмСнтов (МКЭ). ГСомСтрия ΠΌΠΎΠ΄Π΅Π»ΠΈ соотвСтствуСт Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½ΠΎΠΌΡƒ элСктроциклону. Для расчСтов использована k-Ξ΅-модСль турбулСнтности. БистСма ΡƒΡ€Π°Π²Π½Π΅Π½ΠΈΠΉ Ρ€Π΅ΡˆΠ°Π΅Ρ‚ΡΡ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌΠ° SIMPLE. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ расчСта Π΄Π°ΡŽΡ‚ ΠΊΠ°Ρ€Ρ‚ΠΈΠ½Ρƒ распрСдСлСния скоростСй ΠΏΠΎΡ‚ΠΎΠΊΠ° ΠΈ Π»ΠΈΠ½ΠΈΠΉ Ρ‚ΠΎΠΊΠ° Π² Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… сСчСниях. На основании Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² дСлаСтся Π²Ρ‹Π²ΠΎΠ΄ ΠΎ Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ элСктроциклона. ВыявлСн Ρ„Π°ΠΊΡ‚, Ρ‡Ρ‚ΠΎ Π² Π±ΡƒΠ½ΠΊΠ΅Ρ€Π΅ элСктроциклона отсутствуСт Π²ΠΈΡ…Ρ€Π΅Π²ΠΎΠ΅ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠ΅, Ρ‚Π°ΠΊΠΆΠ΅ Π½Π΅Ρ‚ Ρ€Π°Π·Π²ΠΈΡ‚ΠΎΠ³ΠΎ тСчСния Π² области стСнок, Π° Π½ΠΈΠΆΠ΅ Π²Ρ‹Ρ…Π»ΠΎΠΏΠ½ΠΎΠ³ΠΎ отвСрстия ΡΠΊΠΎΡ€ΠΎΡΡ‚ΡŒ ΠΏΠΎΡ‚ΠΎΠΊΠ° Π±Π»ΠΈΠ·ΠΊΠ° ΠΊ 0. Π­Ρ‚ΠΎ благоприятно сказываСтся Π½Π° эффСктивности очистки, Ρ‚. ΠΊ. выходящий чистый Π³Π°Π· Π½Π΅ ΡƒΠ²Π»Π΅ΠΊΠ°Π΅Ρ‚ с собой осСвшиС частицы. Π’Ρ‹Π²ΠΎΠ΄Ρ‹: 1) Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° элСктроциклона ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ описана с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ матСматичСской ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈ рассчитана с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ МКЭ; 2) ΠΏΠΎΡ‚ΠΎΠΊ Π² элСктроциклонС, ΠΊΠ°ΠΊ ΠΈ оТидалось, ΠΈΠΌΠ΅Π΅Ρ‚ Π·Π°ΠΊΡ€ΡƒΡ‡Π΅Π½Π½ΡƒΡŽ структуру, ΡƒΠ³ΠΎΠ» Π·Π°ΠΊΡ€ΡƒΡ‚ΠΊΠΈ зависит ΠΎΡ‚ Π΄Π»ΠΈΠ½Ρ‹ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ Π·ΠΎΠ½Ρ‹; 3) конструкция Π±ΡƒΠ½ΠΊΠ΅Ρ€Π° обСспСчиваСт Π²Ρ‹Ρ…ΠΎΠ΄ ΠΎΡ‡ΠΈΡ‰Π΅Π½Π½ΠΎΠ³ΠΎ Π³Π°Π·Π° Π±Π΅Π· вовлСчСния Π² Π½Π΅Π³ΠΎ ΡƒΠ»ΠΎΠ²Π»Π΅Π½Π½Ρ‹Ρ… частиц.To analyze the elektrocyclone flow hydrodynamic computer calculation using the finite element method (FEM) is applied. The geometry of the model corresponds to the laboratory elektrocyclone. The k-Ξ΅-turbulence model is used for the computation. The system of equations is solved by the SIMPLE algorithm. The calculation results give a pattern of the flow velocity distribution and the flow lines in the different sections. There is conclusion based on the results about the elektrocyclone flow hydrodynamic. Is elicited the fact that in the bunker of an electrocyclone there is no whirl, also there is no developed current in the field of walls, and below an exhaust opening the speed of a stream is close to 0.ИсслСдованиС ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΏΡ€ΠΈ финансовой ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΊΠ΅ ΠΌΠΎΠ»ΠΎΠ΄Ρ‹Ρ… ΡƒΡ‡Π΅Π½Ρ‹Ρ… Π£Ρ€Π€Π£ Π² Ρ€Π°ΠΌΠΊΠ°Ρ… Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΡ‹ развития Π£Ρ€Π€Π£

    Clinicopathological Features and Outcomes of T- and NK-Cell Lymphomas in European Russia

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    With the introduction of the revised World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues in 2001, many patients had to be re-evaluated for the correct diagnosis of T- and NK-cell lymphomas. Because some T-cell malignancies are associated with poor outcome, it is important to identify subsets of patients that may benefit from novel or more intensive therapies. The purpose of this study was to determine, for the first time, the relative frequencies, pathological features and outcomes of patients with T- and NK-cell lymphomas in a predominantly Russian Slavic population. We identified 291 patients with a diagnosis of T- and NK-cell malignancies treated at our Center between 2000-2008. In applying the revised WHO classification, we confirmed the diagnosis and had complete clinical follow up and pathological information on 264 cases that were included in the analysis. We found some differences in frequency of several subsets as compared with previously published reports, including younger age of onset and relatively higher incidence of T-LGL in our patients. We also confirm that intensive treatment regimens of advanced stage PTCL and ALKβ€”ALCL led to considerable improvement in response rates, but not in the overall survival

    Elektrocyclone hydrodynamic flow computation

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    To analyze the elektrocyclone flow hydrodynamic computer calculation using the finite element method (FEM) is applied. The geometry of the model corresponds to the laboratory elektrocyclone. k-Ξ΅-turbulence model is used for the computation. The system of equations is solved by SIMPLE algorithm. The calculation results give a pattern of the flow velocity distribution and flow lines in different sections. There is conclusion based on the results about elektrocyclone flow hydrodynamic.Для Π°Π½Π°Π»ΠΈΠ·Π° Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΏΠΎΡ‚ΠΎΠΊΠ° Π² элСктроциклонС ΠΏΡ€ΠΈΠΌΠ΅Π½Ρ‘Π½ ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½Ρ‹ΠΉ расчСт с использованиСм ΠΌΠ΅Ρ‚ΠΎΠ΄Π° ΠΊΠΎΠ½Π΅Ρ‡Π½Ρ‹Ρ… элСмСнтов (МКЭ). ГСомСтрия ΠΌΠΎΠ΄Π΅Π»ΠΈ соотвСтствуСт Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½ΠΎΠΌΡƒ элСктроциклону. Для расчётов использована k-Ξ΅-модСль турбулСнтности. БистСма ΡƒΡ€Π°Π²Π½Π΅Π½ΠΈΠΉ Ρ€Π΅ΡˆΠ°Π΅Ρ‚ΡΡ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌΠ° SIMPLE. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ расчёта Π΄Π°ΡŽΡ‚ ΠΊΠ°Ρ€Ρ‚ΠΈΠ½Ρƒ распрСдСлСния скоростСй ΠΏΠΎΡ‚ΠΎΠΊΠ° ΠΈ Π»ΠΈΠ½ΠΈΠΉ Ρ‚ΠΎΠΊΠ° Π² Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… сСчСниях. На основании Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² дСлаСтся Π²Ρ‹Π²ΠΎΠ΄ ΠΎ Π³ΠΈΠ΄Ρ€ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ элСктроциклона

    Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial

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    Background: Active-comparator trials are important to inform patient and physician choice. We aimed to evaluate the efficacy and safety of monotherapy with either ustekinumab or adalimumab in biologic-naive patients with moderately to severely active Crohn's disease. Methods: We conducted a randomised, double-blind, parallel-group, active-comparator, phase 3b trial (SEAVUE) at 121 hospitals or private practices in 18 countries. We included biologic-naive patients aged 18 years or older with moderately to severely active Crohn's disease and a Crohn's Disease Activity Index (CDAI) score of 220–450, who had not responded to or were intolerant to conventional therapy (or were corticosteroid dependent) and had at least one ulcer of any size at baseline endoscopic evaluation. Eligible patients were randomly assigned (1:1; via an interactive web response system) to receive ustekinumab (approximately 6 mg/kg intravenously on day 0, then 90 mg subcutaneously once every 8 weeks) or adalimumab (160 mg on day 0, 80 mg at 2 weeks, then 40 mg once every 2 weeks, subcutaneously) through week 56. Study treatments were administered as monotherapy and without dose modifications. Patients, investigators, and study site personnel were masked to treatment group assignment. The primary endpoint was the proportion of patients who were in clinical remission (CDAI score <150) at week 52 in the intention-to-treat population (ie, all patients who were randomly assigned to a treatment group). This trial is registered with ClinicalTrials.gov, NCT03464136, and EudraCT, 2017-004209-41. Findings: Between June 28, 2018, and Dec 12, 2019, 633 patients were assessed for eligibility and 386 were enrolled and randomly assigned to receive ustekinumab (n=191) or adalimumab (n=195). 29 (15%) of 191 patients in the ustekinumab group and 46 (24%) of 195 in the adalimumab group discontinued study treatment before week 52. There was no significant difference between the ustekinumab and adalimumab groups in the occurrence of the primary endpoint; at week 52, 124 (65%) of 191 patients in the ustekinumab group versus 119 (61%) of 195 in the adalimumab group were in clinical remission (between-group difference 4%, 95% CI –6 to 14; p=0Β·42). Safety for both groups was consistent with previous reports. Serious infections were reported in four (2%) of 191 patients in the ustekinumab group and five (3%) of 195 in the adalimumab group. No deaths occurred through week 52 of the study. Interpretation: Both ustekinumab and adalimumab monotherapies were highly effective in this population of biologic-naive patients, with no difference in the primary outcome between the drugs. Funding: Janssen Scientific Affairs
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