Improvement of third-order intermodulation product of RF and microwave amplifiers by injection

This paper discusses the improvement in the third-order intermodulation product (IM3) performance obtainable from RF and microwave amplifiers by two alternative injection techniques. The first is the addition to the amplifier input of the second harmonics of the input spectrum and the second is the addition to the amplifier input of the difference frequencies between the spectral components of the input signal. Both techniques are considered in theory, by simulation and in practice. Both techniques give useful improvements in two-tone IM3 performance. The second harmonic technique reduced the IM3 level by 43 dB in an amplifier at 835 MHz. The difference-frequency technique gave a reduction of 48 dB in an amplifier at 880 MHz. The difference-frequency technique also gives a greater improvement for complex spectra signal

Combining Optimization and Randomization Approaches for the Design of Clinical Trials

t Intentional sampling methods are non-randomized procedures that select a group of individuals for a sample with the purpose of meeting specific prescribed criteria. In this paper we extend previous works related to intentional sampling, and address the problem of sequential allocation for clinical trials with few patients. Roughly speaking, patients are enrolled sequentially, according to the order in which they start the treatment at the clinic or hospital. The allocation problem consists in assigning each new patient to one, and only one, of the alternative treatment arms. The main requisite is that the profiles in the alternative arms remain similar with respect to some relevant patients’ attributes (age, gender, disease, symptom severity and others). We perform numerical experiments based on a real case study and discuss how to conveniently set up perturbation parameters, in order to yield a suitable balance between optimality – the similarity among the relative frequencies of patients in the several categories for both arms, and decoupling – the absence of a tendency to allocate each pair of patients consistently to the same arm