Springback analysis of AA5754 after hot stamping: experiments and FE modelling

In this paper, the springback of the aluminium alloy AA5754 under hot stamping conditions was characterised under stretch and pure bending conditions. It was found that elevated temperature stamping was beneficial for springback reduction, particularly when using hot dies. Using cold dies, the flange springback angle decreased by 9.7 % when the blank temperature was increased from 20 to 450 °C, compared to the 44.1 % springback reduction when hot dies were used. Various other forming conditions were also tested, the results of which were used to verify finite element (FE) simulations of the processes in order to consolidate the knowledge of springback. By analysing the tangential stress distributions along the formed part in the FE models, it was found that the springback angle is a linear function of the average through-thickness stress gradient, regardless of the forming conditions used

Cooperative Interaction between the MUC1-C Oncoprotein and the Rab31 GTPase in Estrogen Receptor-Positive Breast Cancer Cells

Rab31 is a member of the Ras superfamily of small GTPases that has been linked to poor outcomes in patients with breast cancer. The MUC1-C oncoprotein is aberrantly overexpressed in most human breast cancers and also confers a poor prognosis. The present results demonstrate that MUC1-C induces Rab31 expression in estrogen receptor positive (ER+) breast cancer cells. We show that MUC1-C forms a complex with estrogen receptor α (ERα) on the Rab31 promoter and activates Rab31 gene transcription in an estrogen-dependent manner. In turn, Rab31 contributes to the upregulation of MUC1-C abundance in breast cancer cells by attenuating degradation of MUC1-C in lysosomes. Expression of an inactive Rab31(S20N) mutant in nonmalignant breast epithelial cells confirmed that Rab31 regulates MUC1-C expression. The functional significance of the MUC1-C/Rab31 interaction is supported by the demonstration that Rab31 confers the formation of mammospheres by a MUC1-C-dependent mechanism. Analysis of microarray databases further showed that (i) Rab31 is expressed at higher levels in breast cancers as compared to that in normal breast tissues, (ii) MUC1+ and ER+ breast cancers have increased levels of Rab31 expression, and (iii) patients with Rab31-positive breast tumors have a significantly decreased ten-year overall survival as compared to those with Rab31-negative tumors. These findings indicate that MUC1-C and Rab31 function in an autoinductive loop that contributes to overexpression of MUC1-C in breast cancer cells

Study on the Impact of Health Condition Registration and Temperature Check on Inbound Passenger Flow and Optimisation Measures in a Metro Station during the COVID-19 Pandemic

The Guangzhou Metro Authority implemented health condition registration and temperature checks to curb the spread of the virus during the COVID-19 pandemic. However, it is important to investigate how these measures may have impacted the get-through efficiency and whether they caused the increased crowding at entrances and the station hall. To address these questions, simulation models based on the T Station were developed using AnyLogic. The model compared the get-through efficiencies with and without the anti-epidemic measures, while also analysing the risk of crowding at entrances and within the station hall after their implementation. Results revealed an increase in the number of passengers unsuccessfully passing through the check-in gate machines from 15% to 53% within 5 minutes, and 10% to 45% within 10 minutes when the anti-epidemic measures were in place. It was also observed that some entrances experienced significant crowding. Three measures were simulated to find effective ways to increase the get-through efficiency and mitigate the crowding – increasing the distance between security and health checks, utilising automatic infrared thermometers, and arranging volunteers or staff to assist with the registration process. The results demonstrated that using automatic infrared thermometers instead of handheld forehead thermometers proved to be effective in improving passenger efficiency and alleviating crowding at entrances and within the station hall

Defect-enriched iron fluoride-oxide nanoporous thin films bifunctional catalyst for water splitting

Developing cost-effective electrocatalysts operated in the same electrolyte for water splitting, including oxygen and hydrogen evolution reactions, is important for clean energy technology and devices. Defects in electrocatalysts strongly influence their chemical properties and electronic structures, and can dramatically improve electrocatalytic performance. However, the development of defect-activated electrocatalyst with an efficient and stable water electrolysis activity in alkaline medium remains a challenge, and the understanding of catalytic origin is still limited. Here, we highlight defect-enriched bifunctional eletrocatalyst, namely, three-dimensional iron fluoride-oxide nanoporous films, fabricated by anodization/fluorination process. The heterogeneous films with high electrical conductivity possess embedded disorder phases in crystalline lattices, and contain numerous scattered defects, including interphase boundaries, stacking faults, oxygen vacancies, and dislocations on the surfaces/interface. The heterocatalysts efficiently catalyze water splitting in basic electrolyte with remarkable stability. Experimental studies and first-principle calculations suggest that the surface/edge defects contribute significantly to their high performance

Chengdu Model of Young Pioneers’ Socialized Work: Current Situation, Problems and Countermeasures

Through the investigation of the operation mechanism and activities of Red Scarf College in Chengdu, Sichuan Province, it is found that the unique role of Red Scarf College in leading the thought of children is not enough. By means of questionnaire survey, interviews, field observation and other investigation and research methods, it is found that the main reasons for the insufficient guidance of ideological and political education for children in Red Scarf College are insufficient curriculum orientation, team stability, unclear public welfare boundary, and weak publicity strategy. To solve these problems, the following countermeasures can be adopted: to establish a top-down working mechanism by "Party team integration"; To build a series of enlightening courses of political thought with "expert gatekeeping"; To construct the internal and external integration of the disputing chapter system with "internal and external connection"; Broaden the practical education map of the Young pioneers by "co-construction + self-construction".

A Bound on Peak Age of Information Distribution

This paper presents a study on peak age of information (AoI), focusing on its distribution that is more important for AoI guarantees than the mean. Specifically, the relation of peak AoI to the underlying information generation and transmission processes is explicitly formulated. Based on this formulation and by exploring the independence information between the information generation and transmission processes, a general bound on the distribution of peak AoI is derived. To showcase the use of the derived bound, it is applied to two representative cases, which are characterized by the M/M/1 and D/M/1 queuing models. Numerical results obtained from the proposed bound analysis are finally introduced and discussed in comparison with exact results, validating the bound.acceptedVersio