PERBEDAAN RERATA KADAR TRANSFORMING GROWTH FACTOR BETA 1 ANTARA PREEKLAMSI DENGAN HAMIL NORMAL

Preeklamsi merupakan penyebab utama kematian ibu. Penyebab preeklamsi berawal dari gangguan plasenta yang dipengaruhi oleh faktor pro-angiogenik dan anti-angiogenik. Salah satu faktor pro-angiogenik adalah Transforming Growth Faktor Beta1. Transforming Growth Faktor Beta1 merupakan bagian dari keluarga faktor pertumbuhan. Tujuan penelitian untuk membuktikan perbedaan rerata kadar Transforming Growth Faktor Beta1 antara preeklamsi dengan hamil normal. Penelitian dilakukan secara observasional dengan desain cross sectional terhadap 25 ibu preeklamsi dan 25 ibu hamil normal. Pengambilan sampel menggunakan teknik consecutive sampling. Penelitian dilakukan di RS. Dr. Reksodiwiryo, RS. Bhayangkara, RS. Rasidin, Puskesmas Lubuk Buaya dan laboratorium Biomedik Fakultas Kedokteran Unand pada bulan Oktober 2015 sampai Januari 2016. Kadar Transforming Growth Faktor Beta1 diperiksa dengan metode ELISA. Uji normalitas data dengan Shapiro Wilk, uji t tidak berpasangan untuk beda rerata. Hasil karakteristik responden tidak bermakna antara kelompok kasus dan kelompok kontrol dalam hal usia ibu, usia kehamilan, paritas. Karakteristik antara kelompok kasus dan kelompok kontrol adalah homogen. Hasil penelitian didapatkan rerata kadar serum Transforming Growth Faktor Beta1 pada kelompok preeklamsi adalah 2,02±0,99 ng/ml dan 3,24±2,67 ng/ml pada hamil normal. Terdapat perbedaan yang bermakna kadar serum Transforming Growth Faktor Beta1 antara preeklamsi dengan hamil normal dengan nilai p <0,05 Kesimpulan penelitian ini adalah terdapat perbedaan yang signifikan kadar serum Transforming Growth Faktor Beta1 antara preeklamsi dengan hamil normal. Key Word : TGF-β1, Preeklamsia, Kehamilan Normal Preeclampsia is a major cause of maternal mortality. Thecause of preeclampsia originated from placental disorders influenced by pro-angiogenic and anti-angiogenic. One of the pro-angiogenic factors is Transforming Growth Factor Beta1. TGF-β1 is part of a family of growth factor. The aim of research is to prove the differences between the meaning levels of TGF-β1 between preeclampsia and normaly pregnancies. Research conducted observational with cross-sectional design of 25 maternals preeclampsia and 25 normal pregnant women. Sampling using consecutive sampling. The study is conducted at the hospital of Dr. Reksodiwiryo, Bhayangkara hospital, Rasidin hospital, health public centers Lubuk Buaya and laboratories Andalas University Biomedical Faculty of Medicine from October 2015 to January 2016. The level of TGF-β1 examined by ELISA. Normality test data by Shapiro Wilk, unpaired t test for the meaning difference. The results of characteristics of respondents are not significant among the cases and control groups in terms of maternal age, gestational age and parity. Characteristics among the cases and control groups are homogeneous. The result showed the mean serum levels of TGF-β1 in the preeclampsia groupare 2.02±0.99 ng/ml and 3.24±2.67 ng/ml in normal pregnancies. There are significant differences in serum levels of TGF-β1 between preeclampsia with normal pregnant with p <0.05 It is concluded that there are significant differences in serum levels of TGF-β1 between preeclampsia with normal pregnancies. Key Word : TGF-β1, Preeclampsia, normal pregnanc

HUBUNGAN USIA GESTASI DAN BERAT LAHIR DENGAN KEJADIAN HIPERBILIRUBIN PADA BAYI BARU LAHIR

Background: The infant mortality rate is mostly caused by low birth weight (LBW). LBW can occur in infants with premature or term gestational age. LBW infants have risk factors for complications, one of which is hyperbilirubinemia. Methods: The type of research used in this study is correlational analytic method, which is looking for the relationship between one variable and another to determine the relationship between gestational age and birth weight with the incidence of hyperbilirubinemia in newborns. The design used is cross sectional, which is a research design by measuring or observing at the same time, one time or a study. The sampling technique used in this research is non-probability sampling, which is purposive sampling, namely the technique of determining the sample with certain considerations, all subjects who meet the inclusion criteria in the study, and obtained as many as 78 respondents. Results: The results showed that the majority of respondents with good knowledge were 64 people (79.49%), and the majority of respondents with adequate birth weight were 70 people (89.74%). Conclusion: It was identified that the incidence of neonatal jaundice was associated with the incidence of low birth weight babies. Keywords: gestational age, birth weight, hyperbilirubin in BB

Comparison of Transforming Growth Factor-Beta 1 Concentration in Preeclampsia and Normal Pregnancy Women

BACKGROUND: According to the theory of endothelial dysfunction, the pathogenesis of preeclampsia is associated with the imbalance of angiogenic and anti-angiogenic factors. Transforming growth factor-beta 1 (TGF-β1) has also proposed as a proangiogenic factor that influences preeclampsia. This study was conducted to compare a mean difference of TGF-β1 between preeclampsia and normal pregnancy.METHODS: This study was an observational crosssectional study with 25 subjects of pregnant women with preeclampsia and 25 subjects of normotensive pregnant women. The study was conducted in Dr. Reksodiwiryo Hospital, Bhayangkara Hospital, and Dr. Rasidin Hospital in Padang, Indonesia from October 2015 to January 2016. For the determination of TGF-β1 concentration, peripheral Abstract venous blood samples were taken. The blood samples were analyzed by enzyme-linked immunosorbent assay (ELISA) in Biomedical Laboratory, Faculty of Medicine, Andalas University. The mean difference was statically analyzed by independent samples T-test.RESULTS: The mean difference of TGF-β1 was lower in preeclampsia group than normal pregnancy group (2.02±0.99 ng/mL vs. 3.24±2.67 ng/mL; p<0.05).CONCLUSION: The TGF-β1 concentration was lower in pregnant women with preeclampsia. Thus, it may have a role as a marker in preeclampsia.KEYWORDS: preeclampsia, normal pregnancy, transforming growth factor-beta1, TGF-β