Разработка информационной модели данных системы поощрений сотрудников и студентов

В статье рассмотрена система поощрений сотрудников и студентов. Составлена диаграмма сущность-связь процесса учета всех этапов документооборота данного процесса. Представлен пример формы разработанной информационной системы учета и анализа распределения поощрений сотрудниками студентам.The article considers the system of incentives for employees and students. A diagram is drawn of the essence-relationship of the process of accounting for all stages of the workflow of this process. An example of the form of the developed information system of the account and the analysis of distribution of encouragements by employees to students is presented

T -odd proton-helicity asymmetry in semi-inclusive DIS in perturbative QCD

We compute the single-spin asymmetry AUL in semi-inclusive deep-inelastic scattering of unpolarized leptons and longitudinally polarized protons at a large transverse momentum of the produced hadron. Our calculation is performed in collinear factorization at the lowest order of QCD perturbation theory. For photon exchange, the asymmetry is T-odd and receives contributions from the interference of the tree level and one-loop absorptive amplitudes. We consider the behavior of the spin asymmetry at low transverse momentum where contact to the formalism based on transverse momentum dependent distribution functions can be made. We also present some phenomenological results relevant for the COMPASS and HERMES experiments and the future Electron-Ion Collider

Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells

The regulation of acetylation is central for the epigenetic control of lineage-specific gene expression and determines cell fate decisions. We provide evidence that the inhibition of histone deacetylases (HDACs) blocks the endothelial differentiation of adult progenitor cells. To define the mechanisms by which HDAC inhibition prevents endothelial differentiation, we determined the expression of homeobox transcription factors and demonstrated that HoxA9 expression is down-regulated by HDAC inhibitors. The causal involvement of HoxA9 in the endothelial differentiation of adult progenitor cells is supported by the finding that HoxA9 overexpression partially rescued the endothelial differentiation blockade induced by HDAC inhibitors. Knockdown and overexpression studies revealed that HoxA9 acts as a master switch to regulate the expression of prototypical endothelial-committed genes such as endothelial nitric oxide synthase, VEGF-R2, and VE-cadherin, and mediates the shear stress–induced maturation of endothelial cells. Consistently, HoxA9-deficient mice exhibited lower numbers of endothelial progenitor cells and showed an impaired postnatal neovascularization capacity after the induction of ischemia. Thus, HoxA9 is regulated by HDACs and is critical for postnatal neovascularization

Unternehmenskultur, Arbeitsqualität und Mitarbeiterengagement in den Unternehmen in Deutschland: Abschlussbericht Forschungsprojekt Nr. 18/05 ; ein Forschungsprojekt des Bundesministeriums für Arbeit und Soziales

"Der Zusammenhang von Unternehmenskultur, Arbeitsqualität, Mitarbeiterengagement und Unternehmenserfolg ist aufgrund gewonnener Erkenntnisse aus aktuellen Studien wieder in den Fokus der Unternehmer gerückt. Da zu dieser Thematik in Deutschland bisher keine repräsentativen Studien veröffentlicht wurden, zielt das Projekt 'Unternehmenskultur, Arbeitsqualität und Mitarbeiterengagement in den Unternehmen in Deutschland' darauf ab, diese Forschungslücke zu schließen und den Status Quo von Unternehmenskultur in Deutschland darzustellen. Des Weiteren wird der Zusammenhang von Unternehmenskultur und Arbeitsqualität mit dem Mitarbeiterengagement und dem Unternehmenserfolg aufgezeigt, wobei die durchgeführten Analysen ergeben, dass ein bedeutsamer Zusammenhang zwischen Unternehmenskultur, Mitarbeiterengagement und Unternehmenserfolg besteht. Es kann gezeigt werden, dass hinsichtlich der Größen von Unternehmen nur geringfügige Unterschiede bestehen, während zwischen verschiedenen Branchen etwas deutlichere Unterschiede bezüglich des Niveaus verschiedener Dimensionen der Unternehmenskultur zu finden sind. Erfolgsförderliche Merkmale von Unternehmenskultur sowie Maßnahmen aus der Personalarbeit werden präsentiert. Aus den Ergebnissen können aus Unternehmenssicht hilfreiche Interventionsmaßnahmen zur Förderung von Unternehmenskulturen abgeleitet werden. Nach der Einleitung (Kap. 1) werden in diesem Bericht die theoretische Grundlage und das Konzept der daraus entwickelten Studie erläutert (Kap. 2 und Kap. 3). Hierauf basierend werden die erstellten Erhebungsinstrumente und die gewonnene Datengrundlage beschrieben (Kap. 4 und Anhang). Es folgt eine Darstellung der Ergebnisse für die Unternehmen bzw. die Beschäftigten in Deutschland insgesamt (Kap. 5), sowie eine Differenzierung nach verschiedenen Betriebsgrößen (Kap. 6) und Branchen (Kap. 7). Ein Fazit und die Feststellung des weiteren Forschungsbedarfs schließen den Bericht ab (Kap. 8)." (Autorenreferat)"The relationship between organisational culture, quality of work, employee engagement and business success has recently been reconsidered as a result of findings from recent studies. However no representative study on this topic has been conducted in Germany so far. Therefore the current project 'Organisational Culture, Quality of Work and Employee Engagement in Companies in Germany' seeks to close this research gap and to establish a status-quo-analysis of the perceived organisational culture in Germany. The relationship between organisational culture and quality of work, and employee engagement and business success will be described. This insight is then illuminated from different angles to provide possible approaches for interventions. The discrepancies between different sized organisations and the considerable differences between the industries examined in this study will be described. After the introduction (chapter 1), theoretical considerations and the study developed from these will be explained in chapter 2 and 3. Based on this, a description of the questionnaires employed in the survey follows (chapter 4). The gained insights are depicted in chapter 5. Next, several differences in the perceived organisational culture of differently sized organisations (chapter 6) and different branches (chapter 7) are emphasized. Finally, a critical discussion of the results as well as some concluding remarks are presented." (author's abstract

Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment

Objective Trauma-associated cartilage fractures occur in children and adolescents with clinically significant incidence. Several studies investigated biomechanical injury by compressive forces but the injury-related stress has not been investigated extensively. In this study, we hypothesized that the biomechanical stress occurring during compressive injury predetermines the biomechanical, biochemical, and structural consequences. We specifically investigated whether the stress-vs-time signal correlated with the injurious damage and may allow prediction of cartilage matrix fracturing. Methods Superficial and deeper zones disks (SZDs, DZDs; immature bovine cartilage) were biomechanically characterized, injured (50% compression, 100%/s strain-rate), and re-characterized. Correlations of the quantified functional, biochemical and histological damage with biomechanical parameters were zonally investigated. Results Injured SZDs exhibited decreased dynamic stiffness (by 93.04 ± 1.72%), unresolvable equilibrium moduli, structural damage (2.0 ± 0.5 on a 5-point-damage-scale), and 1.78-fold increased sGAG loss. DZDs remained intact. Measured stress-vs-time-curves during injury displayed 4 distinct shapes, which correlated with histological damage (p < 0.001), loss of dynamic stiffness and sGAG (p < 0.05). Damage prediction in a blinded experiment using stress-vs-time grades was 100%-correct and sensitive to differentiate single/complex matrix disruptions. Correlations of the dissipated energy and maximum stress rise with the extent of biomechanical and biochemical damage reached significance when SZDs and DZDs were analyzed as zonal composites but not separately. Conclusions The biomechanical stress that occurs during compressive injury predetermines the biomechanical, biochemical, and structural consequences and, thus, the structural and functional damage during cartilage fracturing. A novel biomechanical method based on the interpretation of compressive yielding allows the accurate prediction of the extent of structural damage.National Institutes of Health (U.S.) (Grant R01-AR45779)Deutsche Forschungsgemeinschaft (Grant RO2511/1-1)Deutsche Forschungsgemeinschaft (Grant RO2511/2-1)Germany. Federal Ministry of Education and Research (Grant 01KQ0902B TP2

Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells

The mechanisms of homing of endothelial progenitor cells (EPCs) to sites of ischemia are unclear. Here, we demonstrate that ex vivo–expanded EPCs as well as murine hematopoietic Sca-1+/Lin− progenitor cells express β2-integrins, which mediate the adhesion of EPCs to endothelial cell monolayers and their chemokine-induced transendothelial migration in vitro. In a murine model of hind limb ischemia, Sca-1+/Lin− hematopoietic progenitor cells from β2-integrin–deficient mice are less capable of homing to sites of ischemia and of improving neovascularization. Preactivation of the β2-integrins expressed on EPCs by activating antibodies augments the EPC-induced neovascularization in vivo. These results provide evidence for a novel function of β2-integrins in postnatal vasculogenesis

Osteoclast-independent bone resorption by fibroblast-like cells

To date, mesenchymal cells have only been associated with bone resorption indirectly, and it has been hypothesized that the degradation of bone is associated exclusively with specific functions of osteoclasts. Here we show, in aseptic prosthesis loosening, that aggressive fibroblasts at the bone surface actively contribute to bone resorption and that this is independent of osteoclasts. In two separate models (a severe combined immunodeficient mouse coimplantation model and a dentin pit formation assay), these cells produce signs of bone resorption that are similar to those in early osteoclastic resorption. In an animal model of aseptic prosthesis loosening (i.e. intracranially self-stimulated rats), it is shown that these fibroblasts acquire their ability to degrade bone early on in their differentiation. Upon stimulation, such fibroblasts readily release acidic components that lower the pH of their pericellular milieu. Through the use of specific inhibitors, pericellular acidification is shown to involve the action of vacuolar type ATPases. Although fibroblasts, as mesenchymal derived cells, are thought to be incapable of resorbing bone, the present study provides the first evidence to challenge this widely held belief. It is demonstrated that fibroblast-like cells, under pathological conditions, may not only enhance but also actively contribute to bone resorption. These cells should therefore be considered novel therapeutic targets in the treatment of bone destructive disorders