Harsh Parenting Reduces Self-Esteem of Adolescents via the Mediation of Interpersonal Sensitivity: The Modulating Role of Dispositional Mindfulness

Adolescence is a critical period for the development of self-esteem, but for many adolescents, self-esteem is compromised by harsh parenting disciplines which are still heavily used. Research into the mechanisms underlying adolescent self-esteem and the strategies that boost self-esteem thus has become very important. Based on the sociometric theory of self-esteem and the attachment theory, the current study explores the role of interpersonal sensitivity and dispositional mindfulness in the effect of harsh parenting on adolescents’ self-esteem. Questionnaire survey on 1320 Chinese adolescents showed that the detrimental effect of harsh parenting could be mediated by interpersonal sensitivity, and this mediation effect was moderated by dispositional mindfulness, participants with higher dispositional mindfulness showed stronger mediation effect than those with lower dispositional mindfulness. Our findings highlight the impact of harsh parenting and the role of interpersonal sensitivity in shaping adolescents’ self-esteem, and suggest the feasibility of mindful intervention programs that take interpersonal sensitivity into account when building the self-worth of adolescents

Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries

Intestinal stem cell (ISC) self-renewal and proliferation are directed by Wnt/β-catenin signaling in mammals, whereas aberrant Wnt pathway activation in ISCs triggers the development of human colorectal carcinoma. Herein, we have utilized the Drosophila midgut, a powerful model for ISC regulation, to elucidate the mechanisms by which Wingless (Wg)/Wnt regulates intestinal homeostasis and development. We provide evidence that the Wg signaling pathway, activation of which peaks at each of the major compartment boundaries of the adult intestine, has essential functions. Wg pathway activation in the intestinal epithelium is required not only to specify cell fate near compartment boundaries during development, but also to control ISC proliferation within compartments during homeostasis. Further, in contrast with the previous focus on Wg pathway activation within ISCs, we demonstrate that the primary mechanism by which Wg signaling regulates ISC proliferation during homeostasis is non-autonomous. Activation of the Wg pathway in absorptive enterocytes is required to suppress JAK-STAT signaling in neighboring ISCs, and thereby their proliferation. We conclude that Wg signaling gradients have essential roles during homeostasis and development of the adult intestine, non-autonomously controlling stem cell proliferation inside compartments, and autonomously specifying cell fate near compartment boundaries

A triclinic polymorph of dichlorido(2-{[2-(isopropyl­ammonio)­eth­yl]imino­methyl-κN}-5-meth­oxy­phenolato-κO 1)zinc

The title compound, [ZnCl2(C13H20N2O2)], was first reported in the monoclinic space group P21/n [Han et al. (2010 ▶). Acta Cryst. E66, m469]. This investigation reveals a triclinic polymorph in the space group P-1 with an asymmetric unit that contains two independent mol­ecules of the mononuclear zinc(II) complex. In each mol­ecule, the ZnII atoms are coordinated in a bidentate fashion by the phenolate O and imine N atoms of the Schiff base ligand. Two Cl− anions complete the tetra­hedral coordination in each case. The most obvious difference between the two forms is that the Zn—L (L = O, N, Cl) bond lengths in both unique mol­ecules are longer than those found in the monoclinic polymorph, or indeed in other similar complexes. In the crystal, mol­ecules are linked through N—H⋯O and N—H⋯Cl hydrogen bonds, forming chains along the b axis