La stimulation du nerf vague dans l’épilepsie

One third of epilepsy patients are resistant to pharmacologic treatment. Vagal nerve stimulation is an alternative choice for those patients. It was first described in the late 1980s and approved by the FDA in 1997. Clinical results show significant improvement in reduction of seizures and quality of life. Complications are low and well tolerated overtime. Large prospective studies are required in patients less than 12 years of age.Un tiers des patients atteints d’épilepsie sont résistants au traitement pharmacologique. La stimulation du nerf vagal est une alternative de choix pour les patients. Il a été décrit pour la première à la fin des années 1980 et approuvé par la FDA en 1997. Les résultats cliniques montrent une amélioration significative dans la réduc- tion des crises et de la qualité de la vie. Les complica- tions sont les heures supplémentaires à faible et bien toléré. Grandes études prospectives sont nécessaires chez les patients d’un âge moins de 12 ans

Enumeration of Coliform Bacteria and E. coli Contaminating the Drinking Water of Al Gedarif City

ABSTRACT The present study enumerated the bacteriological contamination of   the main sources of drinking water in Al Gedarif city. A total of 134 water samples (raw waters, treated waters, main reservoirs, main pipelines, and sabeel zeer waters) were tested for their total coliforms and E. coli counts, using the most probable number technique (MPN). The results indicated that the total coliform and E. coli counts were lower in the ground water sources (Al Azaza and Abu Al Naja boreholes) than that in the surface sources (Atbara River, Al Saraf and Dalassa dams). Moreover, both counts in most of the zeer water samples were higher than those of the other sources. It was also noticed that the zeers located in public areas (market) were more contaminated than the other sabeel zeers. The seasonal variations study was performed for the surface sources, where it was found that the maximum densities of coliform bacteria and   E. coli were occurred during the autumn season and the summer, while the periodical variations study was made for the ground sources, where the coliforms and E. coli densities were found almost higher during the second period of each year

Circulating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease

RATIONALE: Peripheral arterial disease (PAD) is a clinical manifestation of extracoronary atherosclerosis. Despite sharing the same risk factors, only 20% to 30% of patients with coronary artery disease (CAD) develop PAD. Decline in the number of bone marrow–derived circulating progenitor cells (PCs) is thought to contribute to the pathogenesis of atherosclerosis. Whether specific changes in PCs differentiate patients with both PAD and CAD from those with CAD alone is unknown. OBJECTIVE: Determine whether differences exist in PCs counts of CAD patients with and without known PAD. METHODS AND RESULTS: 1497 patients (mean age: 65 years; 62% men) with known CAD were identified in the Emory Cardiovascular Biobank. Presence of PAD (n=308) was determined by history, review of medical records, or imaging and was classified as carotid (53%), lower extremity (41%), upper extremity (3%), and aortic disease (33%). Circulating PCs were enumerated by flow cytometry. Patients with CAD and PAD had significantly lower PC counts compared with those with only CAD. In multivariable analysis, a 50% decrease in cluster of differentiation 34 (CD34+) or CD34+/vascular endothelial growth factor receptor-2 (VEGFR2+) counts was associated with a 31% (P=0.032) and 183% (P=0.002) increase in the odds of having PAD, respectively. CD34+ and CD34+/VEGFR2+ counts significantly improved risk prediction metrics for prevalent PAD. Low CD34+/VEGFR2+ counts were associated with a 1.40-fold (95% confidence interval, 1.03–1.91) and a 1.64-fold (95% confidence interval, 1.07–2.50) increases in the risk of mortality and PAD-related events, respectively. CONCLUSIONS: PAD is associated with low CD34+ and CD34+/VEGFR2+ PC counts. Whether low PC counts are useful in screening for PAD needs to be investigated

Photovoltaic Thermal Collectors Integrated with Phase Change Materials: A Comprehensive Analysis

The target of the current study was to review and analyze the research activities of previous studies on cooling techniques for thermal photovoltaic (PV) systems using phase-change materials. These materials have the ability to absorb and release certain amounts of potential heat energy by changing their state from phase to phase (solid–liquid) within a small temperature range. These materials have been used to regulate and lower the temperature, increase the efficiency, and extend the life of solar cells. A host of improvements have been made to phase-changing materials through the combined utilization of phase-change materials and fins in addition to nanoscale fluids to enhance electrical efficiency. When using PCMs, the thermal, electrical, and overall efficiency improved by 26.87%, 17.33%, and 40.59%, respectively. The addition of nanomaterials increased phase-change materials’ specific heat capacity and thermal conductivity, thus reducing the plate temperature and increasing the electrical efficiency. It was found that using of nanoparticles together with a microcapsule had better performance in terms of energy efficiency. Studies indicated that variable phase materials were not used because of their high cost and lack of stable operational design. Therefore, the effect of phase-change materials on PV/thermal (PVT) system performance needs further investigation and study. © by the authors. Licensee MDPI, Basel, Switzerland.Funding: This project is funded by King Saud University, Riyadh, Saudi Arabia

The impact of diabetes during pregnancy on neonatal outcomes among the Aboriginal population in Western Australia : a whole-population study

DATA AVAILABILITY : The datasets underlying this article were provided by the WA Data Linkage Branch. To access these datasets, researchers should refer to the Data Linkage Branch of the Western Australia Government Department of Health (www.datalinkage-wa.org.au).BACKGROUND : Aboriginal and Torres Strait Islander (hereafter Aboriginal) women have a high prevalence of diabetes in pregnancy (DIP), which includes pre-gestational diabetes mellitus (PGDM) and gestational diabetes mellitus (GDM). We aimed to characterize the impact of DIP in babies born to Aboriginal mothers. METHODS : A retrospective cohort study, using routinely collected linked health data that included all singleton births (N = 510 761) in Western Australia between 1998 and 2015. Stratified by Aboriginal status, generalized linear mixed models quantified the impact of DIP on neonatal outcomes, estimating relative risks (RRs) with 95% CIs. Ratio of RRs (RRRs) examined whether RRs differed between Aboriginal and non-Aboriginal populations. RESULTS : Exposure to DIP increased the risk of adverse outcomes to a greater extent in Aboriginal babies. PGDM heightened the risk of large for gestational age (LGA) (RR: 4.10, 95% CI: 3.56–4.72; RRR: 1.25, 95% CI: 1.09–1.43), macrosomia (RR: 2.03, 95% CI: 1.67–2.48; RRR: 1.39, 95% CI: 1.14–1.69), shoulder dystocia (RR: 4.51, 95% CI: 3.14–6.49; RRR: 2.19, 95% CI: 1.44–3.33) and major congenital anomalies (RR: 2.14, 95% CI: 1.68–2.74; RRR: 1.62, 95% CI: 1.24–2.10). GDM increased the risk of LGA (RR: 2.63, 95% CI: 2.36–2.94; RRR: 2.00, 95% CI: 1.80–2.22), macrosomia (RR: 1.95, 95% CI: 1.72–2.21; RRR: 2.27, 95% CI: 2.01–2.56) and shoulder dystocia (RR: 2.78, 95% CI: 2.12–3.63; RRR: 2.11, 95% CI: 1.61–2.77). Birthweight mediated about half of the DIP effect on shoulder dystocia only in the Aboriginal babies. CONCLUSIONS : DIP differentially increased the risks of fetal overgrowth, shoulder dystocia and congenital anomalies in Aboriginal babies. Improving care for Aboriginal women with diabetes and further research on preventing shoulder dystocia among these women can reduce the disparities.University of Western Australia, Australian Government Research Training Program Scholarship, the Peter and Anne Hector Award, Australian National Health and Medical Council, WA Health and Artificial Intelligence Consortium, the Research Council of Norway.https://academic.oup.com/ijehj2024Internal MedicineSDG-03:Good heatlh and well-bein

Diagnostic Accuracy of the Leishmania OligoC-TesT and NASBA-Oligochromatography for Diagnosis of Leishmaniasis in Sudan

The leishmaniases are a group of vector-borne diseases caused by protozoan parasites of the genus Leishmania. The parasites are transmitted by phlebotomine sand flies and can cause, depending on the infecting species, three clinical manifestations of leishmaniasis: visceral leishmaniasis (VL), post kala-azar dermal leishmaniasis (PKDL) and cutaneous leishmaniasis (CL) including the mucocutaneous form. VL, PKDL as well as CL are endemic in several parts of Sudan, and VL especially represents a major health problem in this country. Molecular tests such as the polymerase chain reaction (PCR) or nucleic acid sequence based assay (NASBA) are powerful techniques for accurate detection of the parasite in clinical specimens, but broad use is hampered by their complexity and lack of standardisation. Recently, the Leishmania OligoC-TesT and NASBA-Oligochromatography were developed as simplified and standardised PCR and NASBA formats. In this study, both tests were phase II evaluated for diagnosis of VL, PKDL and CL in Sudan